Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells

Infection and Immunity

Volumn 79, Issue 10, 2011, Pages 3940-3946

  Shi, Cuixia ^a   Sahay, Bikash ^b   Russell, Jennifer Q ^a   Fortner, Karen A ^a   Hardin, Nicholas ^a   Sellati, Timothy J ^b   Budd, Ralph C ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b ALBANY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM ANTIBODY; CHEMOKINE; CYTOKINE;

ADAPTIVE IMMUNITY; ARTICLE; BORRELIA BURGDORFERI; BORRELIA INFECTION; CARDITIS; CELL COUNT; CELL EXPANSION; CELL FUNCTION; CELL STIMULATION; CYTOKINE PRODUCTION; DENDRITIC CELL; GAMMA DELTA T LYMPHOCYTE; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADAPTIVE IMMUNITY; ANIMALS; ANTIBODIES, BACTERIAL; BORRELIA BURGDORFERI; CHEMOKINES; CYTOKINES; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; HUMANS; LYME DISEASE; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS;

EID: 80855141235     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00148-11     Document Type: Article

References (42)

1. Ashany, D., A. Savir, N. Bhardwaj, and K. B. Elkon. 1999. Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway. J. Immunol. 163:5303-5311.
2. Aydintug, M. K., et al. 2004. Detection of cell surface ligands for the gamma delta TCR using soluble TCRs. J. Immunol. 172:4167-4175.
3. Barthold, S. W., D. S. Beck, G. M. Hansen, G. A. Terwilliger, and K. D. Moody. 1990. Lyme borreliosis in selected strains and ages of laboratory mice. J. Infect. Dis. 162:133-138.
4. Bockenstedt, L. K., M. C. Shanafelt, A. Belperron, J. Mao, and S. W. Barthold. 2003. Humoral immunity reflects altered T helper cell bias in Borrelia burgdorferi-infected gamma delta T-cell-deficient mice. Infect. Immun. 71:2938-2940.
5. Callister, S. M., R. F. Schell, and S. D. Lovrich. 1991. Lyme disease assay which detects killed Borrelia burgdorferi. J. Clin. Microbiol. 29:1773-1776.
6. Chien, Y. H., R. Jores, and M. P. Crowley. 1996. Recognition by gamma/delta T cells. Annu. Rev. Immunol. 14:511-532.
7. Collins, C., C. Shi, J. Q. Russell, K. A. Fortner, and R. C. Budd. 2008. Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway. J. Immunol. 181:2392-2398.
8. Collins, C., et al. 2005. Lyme arthritis synovial gamma delta T cells instruct dendritic cells via fas ligand. J. Immunol. 175:5656-5665.
9. + T cell activation through caspase-8-dependent NF-kappa B activation. J. Immunol. 174:5270-5278.
10. Fikrig, E., S. W. Barthold, F. S. Kantor, and R. A. Flavell. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250:553-556.
11. Hirschfeld, M., et al. 1999. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 163:2382-2386.
12. Huber, S., C. Shi, and R. C. Budd. 2002. γδ T cells promote a Th1 response during coxsackievirus B3 infection in vivo: role of Fas and Fas ligand. J. Virol. 76:6487-6494.
13. Itohara, S., et al. 1993. T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes. Cell 72:337-348.
14. Kataoka, T., et al. 2000. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr. Biol. 10:640-648.
15. Kataoka, T., and J. Tschopp. 2004. N-terminal fragment of c-FLIP(L) processed by caspase 8 specifically interacts with TRAF2 and induces activation of the NF-κB signaling pathway. Mol. Cell. Biol. 24:2627-2636.
16. Kawano, T., et al. 1997. CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides. Science 278:1626-1629.
17. Kinjo, Y., et al. 2006. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7:978-986.
18. Lee, Y. K., et al. 2009. Late developmental plasticity in the T helper 17 lineage. Immunity 30:92-107.
19. Lutz, M. B., et al. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223:77-92.
20. Mixter, P. F., V. Camerini, B. J. Stone, V. L. Miller, and M. Kronenberg. 1994. Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo. Infect. Immun. 62:4618-4621.
21. Montoya, C. J., et al. 2006. Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells. J. Immunol. 177:1028-1039.
22. Paget, C., et al. 2007. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity 27:597-609.
23. Peterman, G. M., C. Spencer, A. I. Sperling, and J. A. Bluestone. 1993. Role of gamma delta T cells in murine collagen-induced arthritis. J. Immunol. 151:6546-6558.
24. Roark, C. L., et al. 2007. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J. Immunol. 179:5576-5583.
25. Roessner, K., et al. 1994. Prominent T lymphocyte response to Borrelia burgdorferi from peripheral blood of unexposed donors. Eur. J. Immunol. 24:320-324.
26. Roessner, K., et al. 2003. High expression of Fas ligand by synovial fluidderived gamma delta T cells in Lyme arthritis. J. Immunol. 170:2702-2710.
27. + T cells during experimental infection of mice with Leishmania major. J. Immunol. 150:550-555.
28. Shi, C., et al. 2006. Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi. Infect. Immun. 74:1156-1160.
29. Steere, A. C. 1989. Lyme disease. N. Engl. J. Med. 321:586-596.
30. Steere, A. C., et al. 1983. The early clinical manifestations of Lyme disease. Ann. Intern. Med. 99:76-82.
31. Steere, A. C., P. H. Duray, and E. C. Butcher. 1988. Spirochetal antigens and lymphoid cell surface markers in Lyme synovitis: comparison with rheumatoid synovium and tonsillar lymphoid tissue. Arthritis Rheum. 31:487-497.
32. Steere, A. C., E. Dwyer, and R. Winchester. 1990. Association of chronic Lyme arthritis with HLA-DR4 and HLA-DR2 alleles. N. Engl. J. Med. 323:219-223. [Erratum, 324(2):129, 1991.]
33. Steere, A. C., et al. 1983. The spirochetal etiology of Lyme disease. N. Engl. J. Med. 308:733-740.
34. Steere, A. C., R. T. Schoen, and E. Taylor. 1987. The clinical evolution of Lyme arthritis. Ann. Intern. Med. 107:725-731.
35. Tough, D. F., and J. Sprent. 1998. Lifespan of gamma/delta T cells. J. Exp. Med. 187:357-365.
36. Tsuji, M., et al. 1994. Gamma delta T cells contribute to immunity against the liver stages of malaria in alpha beta T-cell-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 91:345-349.
37. Tupin, E., et al. 2008. NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proc. Natl. Acad. Sci. U. S. A. 105:19863-19868.
38. + synovial T cells by Borrelia reactive Fas ligand high gamma delta T cells in Lyme arthritis. J. Exp. Med. 184:2109-2117.
39. Vincent, M. S., et al. 1998. Lyme arthritis synovial gamma delta T cells respond to Borrelia burgdorferi lipoproteins and lipidated hexapeptides. J. Immunol. 161:5762-5771.
40. Wang, J., et al. 2010. Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells. Proc. Natl. Acad. Sci. U. S. A. 107:1535-1540.
41. Weis, J. J. 2002. Host-pathogen interactions and the pathogenesis of murine Lyme disease. Curr. Opin. Rheumatol. 14:399-403.
42. Wu, D., et al. 2005. Bacterial glycolipids and analogs as antigens for CD1drestricted NKT cells. Proc. Natl. Acad. Sci. U. S. A. 102:1351-1356.