Effect of acute administration of vitamin C on muscle sympathetic activity, cardiac sympathovagal balance, and baroreflex sensitivity in hypertensive patients

American Journal of Clinical Nutrition

Volumn 96, Issue 2, 2012, Pages 302-308

  Bruno, Rosa M ^a   Daghini, Elena ^a   Ghiadoni, Lorenzo ^a   Sudano, Isabella ^b   Rugani, Ilaria ^a   Varanini, Maurizio ^c   Passino, Claudio ^c   Emdin, Michele ^c   Taddei, Stefano ^a  

^a UNIVERSITY HOSPITAL OF PISA   (Italy)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ASCORBIC ACID; NITROPRUSSIDE SODIUM; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADRENERGIC SYSTEM; ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CONTROLLED STUDY; DEVICES; DRUG EFFECT; DRUG INFUSION; ELECTROCARDIOGRAM; ESSENTIAL HYPERTENSION; FEMALE; HEART; HEART RATE; HEMODYNAMIC PARAMETERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MUSCLE; NEUROGRAPHY; NORADRENALIN BLOOD LEVEL; OXIDATIVE STRESS; PLETHYSMOGRAPHY; PRESSORECEPTOR REFLEX; RR INTERVAL; SYMPATHETIC NERVE; VAGUS NERVE;

ADULT; ASCORBIC ACID; BAROREFLEX; BLOOD PRESSURE; CASE-CONTROL STUDIES; FEMALE; HEART; HEART RATE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; MUSCLES; NITROPRUSSIDE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SYMPATHETIC NERVOUS SYSTEM;

EID: 84864332637     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.035022     Document Type: Article

References (35)

1. Guzzetti S, Piccaluga E, Casati R, Cerutti S, Lombardi F, Pagani M, Malliani A. Sympathetic predominance in essential hypertension: a study employing spectral analysis of heart rate variability. J Hypertens 1988;6:711-7.
2. Grassi G, Cattaneo BM, Seravalle G, Lanfranchi A, Mancia G. Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension 1998;31:68-72. (Pubitemid 28124694)
3. Delles C, Miller WH, Dominiczak AF. Targeting reactive oxygen species in hypertension. Antioxid Redox Signal 2008;10:1061-77. (Pubitemid 351451714)
4. Shokoji T, Nishiyama A, Fujisawa Y, Hitomi H, Kiyomoto H, Takahashi N, Kimura S, Kohno M, Abe Y. Renal sympathetic nerve responses to tempol in spontaneously hypertensive rats. Hypertension 2003;41:266-73. (Pubitemid 36204900)
5. Campese VM, Shaohua Y, Huiquin Z. Oxidative stress mediates angiotensin II-dependent stimulation of sympathetic nerve activity. Hypertension 2005;46:533-9. (Pubitemid 41376834)
6. Ye S, Zhong H, Yanamadala S, Campese VM. Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension. Hypertension 2006;48:309-15. (Pubitemid 44309828)
7. Oliveira-Sales EB, Dugaich AP, Carillo BA, Abreu NP, Boim MA, Martins PJ, D'Almeida V, Dolnikoff MS, Bergamaschi CT, Campos RR. Oxidative stress contributes to renovascular hypertension. Am J Hypertens 2008;21:98-104.
8. Bell C, Jones PP, Seals DR. Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans. J Clin Endocrinol Metab 2003;88:4950-4. (Pubitemid 37357549)
9. Piccirillo G, Nocco M, Moise A, Lionetti M, Naso C, di Carlo S, Marigliano V. Influence of vitamin C on baroreflex sensitivity in chronic heart failure. Hypertension 2003;41:1240-5. (Pubitemid 36706072)
10. Nightingale AK, Blackman DJ, Field R, Glover NJ, Pegge N, Mumford C, Schmitt M, Ellis GR, Morris-Thurgood JA, Frenneaux MP. Role of nitric oxide and oxidative stress in baroreceptor dysfunction in patients with chronic heart failure. Clin Sci (Lond) 2003;104:529-35. (Pubitemid 36628149)
11. Bogert LW, van Lieshout JJ. Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger. Exp Physiol 2005;90:437-46. (Pubitemid 40980142)
12. Bruno RM, Sudano I, Ghiadoni L, Masi L, Taddei S. Interactions between sympathetic nervous system and endogenous endothelin in patients with essential hypertension. Hypertension 2011;57:79-84.
13. Delius W, Hagbarth KE, Hongell A, Wallin BG. General characteristics of sympathetic activity in human muscle nerves. Acta Physiol Scand 1972;84:65-81.
14. Muscelli E, Emdin M, Natali A, Pratali L, Camastra S, Gastaldelli A, Baldi S, Carpeggiani C, Ferrannini E. Autonomic and hemodynamic responses to insulin in lean and obese humans. J Clin Endocrinol Metab 1998;83:2084-90. (Pubitemid 28496341)
15. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 1996;93:1043-65.
16. Schindler TH, Magosaki N, Jeserich M, Olschewski M, Nitzsche E, Holubarsch C, Solzbach U, Just H. Effect of ascorbic acid on endothelial dysfunction of epicardial coronary arteries in chronic smokers assessed by cold pressor testing. Cardiology 2000;94:239-46. (Pubitemid 32402286)
17. Ellis GR, Anderson RA, Lang D, Blackman DJ, Morris RH, Morris-Thurgood J, McDowell IF, Jackson SK, Lewis MJ, Frenneaux MP. Neutrophil superoxide anion-generating capacity, endothelial function and oxidative stress in chronic heart failure: effects of short- and long-term vitamin C therapy. J Am Coll Cardiol 2000;36:1474-82.
18. Esler M, Kaye D. Sympathetic nervous system activation in essential hypertension, cardiac failure and psychosomatic heart disease. J Cardiovasc Pharmacol 2000;35(suppl 4):S1-7.
19. Kishi T, Hirooka Y, Kimura Y, Ito K, Shimokawa H, Takeshita A. Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation 2004;109:2357-62. (Pubitemid 38656873)
20. Kimura Y, Hirooka Y, Sagara Y, Ito K, Kishi T, Shimokawa H, Takeshita A, Sunagawa K. Overexpression of inducible nitric oxide synthase in rostral ventrolateral medulla causes hypertension and sympathoexcitation via an increase in oxidative stress. Circ Res 2005;96:252-60. (Pubitemid 40209373)
21. Xu H, Fink GD, Chen A, Watts S, Galligan JJ. Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in normotensive rats. Am J Physiol Heart Circ Physiol 2001;281:H975-80.
22. Agus DB, Gambhir SS, Pardridge WM, Spielholz C, Baselga J, Vera JC, Golde DW. Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J Clin Invest 1997;100:2842-8. (Pubitemid 28007554)
23. Lin HH, Chen CH, Hsieh WK, Chiu TH, Lai CC. Hydrogen peroxide increases the activity of rat sympathetic preganglionic neurons in vivo and in vitro. Neuroscience 2003;121:641-7. (Pubitemid 38367503)
24. Cao X, Dai X, Parker LM, Kreulen DL. Differential regulation of NADPH oxidase in sympathetic and sensory ganglia in deoxycorticosterone acetate salt hypertension. Hypertension 2007;50:663-71. (Pubitemid 47442729)
25. Shokoji T, Fujisawa Y, Kimura S, Rahman M, Kiyomoto H, Matsubara K, Moriwaki K, Aki Y, Miyatake A, Kohno M, et al. Effects of local administrations of tempol and diethyldithio-carbamic on peripheral nerve activity. Hypertension 2004;44:236-43. (Pubitemid 39014243)
26. Grassi G, Seravalle G, Bolla G, Quarti-Trevano F, Dell'Oro R, Arenare F, Mancia G. Heart rate as a sympathetic marker during acute adrenergic challenge. J Hypertens 2008;26:70-5. (Pubitemid 350294851)
27. Grassi G, Bolla G, Seravalle G, Turri C, Lanfranchi A, Mancia G. Comparison between reproducibility and sensitivity of muscle sympathetic nerve traffic and plasma noradrenaline in man. Clin Sci (Lond) 1997;92:285-9. (Pubitemid 27129442)
28. Lucini D, Mela GS, Malliani A, Pagani M. Impairment in cardiac autonomic regulation preceding arterial hypertension in humans: insights from spectral analysis of beat-by-beat cardiovascular variability. Circulation 2002;106:2673-9. (Pubitemid 35364921)
29. Huber DA, Schreihofer AM. Attenuated baroreflex control of sympathetic nerve activity in obese Zucker rats by central mechanisms. J Physiol 2010;588:1515-25.
30. Monahan KD, Eskurza I, Seals DR. Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men. Am J Physiol Heart Circ Physiol 2004;286:H2113-7. (Pubitemid 38685224)
31. Li Z, Mao HZ, Abboud FM, Chapleau MW. Oxygen-derived free radicals contribute to baroreceptor dysfunction in atherosclerotic rabbits. Circ Res 1996;79:802-11. (Pubitemid 26317828)
32. Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF Jr, Vita JA. Treatment of hypertension with ascorbic acid. Lancet 1999;354:2048-9.
33. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 1998;97:2222-9. (Pubitemid 28265383)
34. Macarthur H, Westfall TC, Wilken GH. Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2008;294:H183-9.
35. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M. Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 2004;140:533-7.