Flexible and versatile as a Chameleon-Sophisticated functions of microRNA-199a

International Journal of Molecular Sciences

Volumn 13, Issue 7, 2012, Pages 8449-8466

  Gu, Shen ^a   Chan, Wai Yee ^a  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

Author keywords

microRNA; miRNA 199a; Targets

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MICRORNA; MICRORNA 199A; OLTIPRAZ; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST1; UNCLASSIFIED DRUG; MIRN199 MICRORNA, HUMAN;

ADIPOGENESIS; ANTIVIRAL ACTIVITY; BONE DEVELOPMENT; CARCINOGENESIS; CELL DIFFERENTIATION; CELL HYPOXIA; CHONDROGENESIS; DNA METHYLATION; DOWN REGULATION; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; GENE EXPRESSION REGULATION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEPATITIS; HUMAN; LIVER FIBROSIS; NONHUMAN; ONCOGENE; PROMOTER REGION; REVIEW; TUMOR SUPPRESSOR GENE; UPREGULATION; ANIMAL; GENETICS; METABOLISM; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RNA INTERFERENCE;

PROTEA;

ANIMALS; BASE SEQUENCE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; MOLECULAR SEQUENCE DATA; NEOPLASMS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE;

EID: 84864326364     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13078449     Document Type: Review

References (89)

1. Lagos-Quintana, M.; Rauhut, R.; Meyer, J.; Borkhardt, A.; Tuschl, T. New micrornas from mouse and human. RNA 2003, 9, 175-179.
2. Kozomara, A.; Griffiths-Jones, S. MiRbase: Integrating microrna annotation and deep-sequencing data. Nucleic Acids Res. 2011, 39, D152-D157.
3. Krichevsky, A.M.; Gabriely, G. MiR-21: A small multi-faceted rna. J. Cell. Mol. Med. 2009, 13, 39-53.
4. Lim, L.P.; Glasner, M.E.; Yekta, S.; Burge, C.B.; Bartel, D.P. Vertebrate microrna genes. Science 2003, 299, 1540.
5. Landgraf, P.; Rusu, M.; Sheridan, R.; Sewer, A.; Iovino, N.; Aravin, A.; Pfeffer, S.; Rice, A.; Kamphorst, A.O.; Landthaler, M.; et al. A mammalian microrna expression atlas based on small rna library sequencing. Cell 2007, 129, 1401-1414.
6. Lee, Y.B.; Bantounas, I.; Lee, D.Y.; Phylactou, L.; Caldwell, M.A.; Uney, J.B. Twist-1 regulates the miR-199a/214 cluster during development. Nucleic Acids Res. 2009, 37, 123-128.
7. Yin, G.; Chen, R.; Alvero, A.B.; Fu, H.H.; Holmberg, J.; Glackin, C.; Rutherford, T.; Mor, G. Twisting stemness, inflammation and proliferation of epithelial ovarian cancer cells through miR199a2/214. Oncogene 2010, 29, 3545-3553.
8. Watanabe, T.; Sato, T.; Amano, T.; Kawamura, Y.; Kawamura, N.; Kawaguchi, H.; Yamashita, N.; Kurihara, H.; Nakaoka, T. Dnm3os, a non-coding rna, is required for normal growth and skeletal development in mice. Dev. Dyn. 2008, 237, 3738-3748.
9. Kim, S.; Lee, U.J.; Kim, M.N.; Lee, E.J.; Kim, J.Y.; Lee, M.Y.; Choung, S.; Kim, Y.J.; Choi, Y.C. Microrna miR-199a* regulates the met proto-oncogene and the downstream extracellular signal-regulated kinase 2 (erk2). J. Biol. Chem. 2008, 283, 18158-18166.
10. Fujita, S.; Iba, H. Putative promoter regions of miRna genes involved in evolutionarily conserved regulatory systems among vertebrates. Bioinformatics 2008, 24, 303-308.
11. Cheung, H.H.; Lee, T.L.; Davis, A.J.; Taft, D.H.; Rennert, O.M.; Chan, W.Y. Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding rnas in human testicular cancer. Br. J. Cancer 2010, 102, 419-427.
12. Mudduluru, G.; Ceppi, P.; Kumarswamy, R.; Scagliotti, G.V.; Papotti, M.; Allgayer, H. Regulation of axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancer. Oncogene 2011, 30, 2888-2899.
13. Sakurai, K.; Furukawa, C.; Haraguchi, T.; Inada, K.; Shiogama, K.; Tagawa, T.; Fujita, S.; Ueno, Y.; Ogata, A.; Ito, M.; et al. Micrornas miR-199a-5p and -3p target the brm subunit of swi/snf to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 2011, 71, 1680-1689.
14. Loebel, D.A.; Tsoi, B.; Wong, N.; Tam, P.P. A conserved noncoding intronic transcript at the mouse dnm3 locus. Genomics 2005, 85, 782-789.
15. Wienholds, E.; Kloosterman, W.P.; Miska, E.; Alvarez-Saavedra, E.; Berezikov, E.; de Bruijn, E.; Horvitz, H.R.; Kauppinen, S.; Plasterk, R.H. Microrna expression in zebrafish embryonic development. Science 2005, 309, 310-311.
16. Yi, R.; O'Carroll, D.; Pasolli, H.A.; Zhang, Z.; Dietrich, F.S.; Tarakhovsky, A.; Fuchs, E. Morphogenesis in skin is governed by discrete sets of differentially expressed micrornas. Nat. Genet. 2006, 38, 356-362.
17. van Rooij, E.; Sutherland, L.B.; Liu, N.; Williams, A.H.; McAnally, J.; Gerard, R.D.; Richardson, J.A.; Olson, E.N. A signature pattern of stress-responsive micrornas that can evoke cardiac hypertrophy and heart failure. Proc. Natl. Acad. Sci. USA 2006, 103, 18255-18260.
18. Fischer, L.; Hummel, M.; Korfel, A.; Lenze, D.; Joehrens, K.; Thiel, E. Differential micro-rna expression in primary cns and nodal diffuse large b-cell lymphomas. Neuro-Oncology 2011, 13, 1090-1098.
19. Santhakumar, D.; Forster, T.; Laqtom, N.N.; Fragkoudis, R.; Dickinson, P.; Abreu-Goodger, C.; Manakov, S.A.; Choudhury, N.R.; Griffiths, S.J.; Vermeulen, A.; et al. Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral micrornas. Proc. Natl. Acad. Sci. USA 2010, 107, 13830-13835.
20. Hou, J.; Lin, L.; Zhou, W.; Wang, Z.; Ding, G.; Dong, Q.; Qin, L.; Wu, X.; Zheng, Y.; Yang, Y.; et al. Identification of miRnomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell 2011, 19, 232-243.
21. Lee, C.G.; Kim, Y.W.; Kim, E.H.; Meng, Z.; Huang, W.; Hwang, S.J.; Kim, S.G. Farnesoid X receptor protects hepatocytes from injury by repressing miR-199a-3p, which increases levels of lkb1. Gastroenterology 2012, 142, 1206-1217.e7.
22. Rane, S.; He, M.; Sayed, D.; Yan, L.; Vatner, D.; Abdellatif, M. An antagonism between the akt and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cell. Signal. 2010, 22, 1054-1062.
23. Sayed, D.; Abdellatif, M. Akt-ing via microrna. Cell Cycle 2010, 9, 3213-3217.
24. Haghikia, A.; Missol-Kolka, E.; Tsikas, D.; Venturini, L.; Brundiers, S.; Castoldi, M.; Muckenthaler, M.U.; Eder, M.; Stapel, B.; Thum, T.; et al. Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: A key role for ubiquitin-conjugating enzymes. Eur. Heart J. 2011, 32, 1287-1297.
25. Lin, E.A.; Kong, L.; Bai, X.H.; Luan, Y.; Liu, C.J. MiR-199a, a bone morphogenic protein 2-responsive microrna, regulates chondrogenesis via direct targeting to smad1. J. Biol. Chem. 2009, 284, 11326-11335.
26. Tsukigi, M.; Bilim, V.; Yuuki, K.; Ugolkov, A.; Naito, S.; Nagaoka, A.; Kato, T.; Motoyama, T.; Tomita, Y. Re-expression of miR-199a suppresses renal cancer cell proliferation and survival by targeting gsk-3beta. Cancer Lett. 2012, 315, 189-197.
27. Song, G.; Zeng, H.; Li, J.; Xiao, L.; He, Y.; Tang, Y.; Li, Y. MiR-199a regulates the tumor suppressor mitogen-activated protein kinase kinase kinase 11 in gastric cancer. Biol. Pharm. Bull. 2010, 33, 1822-1827.
28. Brenner, B.; Hoshen, M.B.; Purim, O.; David, M.B.; Ashkenazi, K.; Marshak, G.; Kundel, Y.; Brenner, R.; Morgenstern, S.; Halpern, M.; et al. Micrornas as a potential prognostic factor in gastric cancer. World J. Gastroenterol. 2011, 17, 3976-3985.
29. Ueda, T.; Volinia, S.; Okumura, H.; Shimizu, M.; Taccioli, C.; Rossi, S.; Alder, H.; Liu, C.G.; Oue, N.; Yasui, W.; et al. Relation between microrna expression and progression and prognosis of gastric cancer: A microrna expression analysis. Lancet Oncol. 2010, 11, 136-146.
30. Shigehara, K.; Yokomuro, S.; Ishibashi, O.; Mizuguchi, Y.; Arima, Y.; Kawahigashi, Y.; Kanda, T.; Akagi, I.; Tajiri, T.; Yoshida, H.; et al. Real-time pcr-based analysis of the human bile micrornaome identifies miR-9 as a potential diagnostic biomarker for biliary tract cancer. PLoS One 2011, 6, e23584.
31. Jiang, J.; Gusev, Y.; Aderca, I.; Mettler, T.A.; Nagorney, D.M.; Brackett, D.J.; Roberts, L.R.; Schmittgen, T.D. Association of microrna expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin. Cancer Res. 2008, 14, 419-427.
32. Jia, X.Q.; Cheng, H.Q.; Qian, X.; Bian, C.X.; Shi, Z.M.; Zhang, J.P.; Jiang, B.H.; Feng, Z.Q. Lentivirus-mediated overexpression of microrna-199a inhibits cell proliferation of human hepatocellular carcinoma. Cell Biochem. Biophys. 2012, 62, 237-244.
33. Henry, J.C.; Park, J.K.; Jiang, J.; Kim, J.H.; Nagorney, D.M.; Roberts, L.R.; Banerjee, S.; Schmittgen, T.D. MiR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem. Biophys. Res. Commun. 2010, 403, 120-125.
34. Shen, Q.; Cicinnati, V.R.; Zhang, X.; Iacob, S.; Weber, F.; Sotiropoulos, G.C.; Radtke, A.; Lu, M.; Paul, A.; Gerken, G.; Beckebaum, S. Role of microrna-199a-5p and discoidin domain receptor 1 in human hepatocellular carcinoma invasion. Mol. Cancer 2010, 9, 227.
35. Fornari, F.; Milazzo, M.; Chieco, P.; Negrini, M.; Calin, G.A.; Grazi, G.L.; Pollutri, D.; Croce, C.M.; Bolondi, L.; Gramantieri, L. MiR-199a-3p regulates mtor and c-met to influence the doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res. 2010, 70, 5184-5193.
36. Qu, K.Z.; Zhang, K.; Li, H.; Afdhal, N.H.; Albitar, M. Circulating micrornas as biomarkers for hepatocellular carcinoma. J. Clin. Gastroenterol. 2011, 45, 355-360.
37. Magrelli, A.; Azzalin, G.; Salvatore, M.; Viganotti, M.; Tosto, F.; Colombo, T.; Devito, R.; Di Masi, A.; Antoccia, A.; Lorenzetti, S.; et al. Altered microrna expression patterns in hepatoblastoma patients. Transl. Oncol. 2009, 2, 157-163.
38. Duan, Z.; Choy, E.; Harmon, D.; Liu, X.; Susa, M.; Mankin, H.; Hornicek, F. Microrna-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol. Cancer Ther. 2011, 10, 1337-1345.
39. Feber, A.; Xi, L.; Pennathur, A.; Gooding, W.E.; Bandla, S.; Wu, M.; Luketich, J.D.; Godfrey, T.E.; Litle, V.R. Microrna prognostic signature for nodal metastases and survival in esophageal adenocarcinoma. Ann. Thorac. Surg. 2011, 91, 1523-1530.
40. Cheung, H.H.; Davis, A.J.; Lee, T.L.; Pang, A.L.; Nagrani, S.; Rennert, O.M.; Chan, W.Y. Methylation of an intronic region regulates miR-199a in testicular tumor malignancy. Oncogene 2011, 30, 3404-3415.
41. Wang, F.; Zheng, Z.; Guo, J.; Ding, X. Correlation and quantitation of microrna aberrant expression in tissues and sera from patients with breast tumor. Gynecol. Oncol. 2010, 119, 586-593.
42. Ballabio, E.; Mitchell, T.; van Kester, M.S.; Taylor, S.; Dunlop, H.M.; Chi, J.; Tosi, I.; Vermeer, M.H.; Tramonti, D.; Saunders, N.J.; et al. Microrna expression in sezary syndrome: Identification, function, and diagnostic potential. Blood 2010, 116, 1105-1113.
43. Iorio, M.V.; Visone, R.; di Leva, G.; Donati, V.; Petrocca, F.; Casalini, P.; Taccioli, C.; Volinia, S.; Liu, C.G.; Alder, H.; et al. Microrna signatures in human ovarian cancer. Cancer Res. 2007, 67, 8699-8707.
44. Nam, E.J.; Yoon, H.; Kim, S.W.; Kim, H.; Kim, Y.T.; Kim, J.H.; Kim, J.W.; Kim, S. Microrna expression profiles in serous ovarian carcinoma. Clin. Cancer Res. 2008, 14, 2690-2695.
45. Yang, H.; Kong, W.; He, L.; Zhao, J.J.; O'Donnell, J.D.; Wang, J.; Wenham, R.M.; Coppola, D.; Kruk, P.A.; Nicosia, S.V.; et al. Microrna expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting pten. Cancer Res. 2008, 68, 425-433.
46. Chen, R.; Alvero, A.B.; Silasi, D.A.; Kelly, M.G.; Fest, S.; Visintin, I.; Leiser, A.; Schwartz, P.E.; Rutherford, T.; Mor, G. Regulation of ikkbeta by miR-199a affects nf-kappab activity in ovarian cancer cells. Oncogene 2008, 27, 4712-4723.
47. Jukic, D.M.; Rao, U.N.; Kelly, L.; Skaf, J.S.; Drogowski, L.M.; Kirkwood, J.M.; Panelli, M.C. Microrna profiling analysis of differences between the melanoma of young adults and older adults. J. Transl. Med. 2010, 8, 27.
48. Worley, L.A.; Long, M.D.; Onken, M.D.; Harbour, J.W. Micro-rnas associated with metastasis in uveal melanoma identified by multiplexed microarray profiling. Melanoma Res. 2008, 18, 184-190.
49. Ichimi, T.; Enokida, H.; Okuno, Y.; Kunimoto, R.; Chiyomaru, T.; Kawamoto, K.; Kawahara, K.; Toki, K.; Kawakami, K.; Nishiyama, K.; et al. Identification of novel microrna targets based on microrna signatures in bladder cancer. Int. J. Cancer 2009, 125, 345-352.
50. Mascaux, C.; Laes, J.F.; Anthoine, G.; Haller, A.; Ninane, V.; Burny, A.; Sculier, J.P. Evolution of microrna expression during human bronchial squamous carcinogenesis. Eur. Respir. J. 2009, 33, 352-359.
51. Lee, J.W.; Choi, C.H.; Choi, J.J.; Park, Y.A.; Kim, S.J.; Hwang, S.Y.; Kim, W.Y.; Kim, T.J.; Lee, J.H.; Kim, B.G.; Bae, D.S. Altered microrna expression in cervical carcinomas. Clin. Cancer Res. 2008, 14, 2535-2542.
52. Garzon, R.; Volinia, S.; Liu, C.G.; Fernandez-Cymering, C.; Palumbo, T.; Pichiorri, F.; Fabbri, M.; Coombes, K.; Alder, H.; Nakamura, T.; et al. Microrna signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008, 111, 3183-3189.
53. Zhao, Y.; Xie, P.; Fan, H. Genomic profiling of micrornas and proteomics reveals an early molecular alteration associated with tumorigenesis induced by MC-LR in mice. Environ. Sci. Technol. 2012, 46, 34-41.
54. Bockmeyer, C.L.; Christgen, M.; Muller, M.; Fischer, S.; Ahrens, P.; Langer, F.; Kreipe, H.; Lehmann, U. Microrna profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes. Breast Cancer Res. Treat. 2011, 130, 735-745.
55. Shatseva, T.; Lee, D.Y.; Deng, Z.; Yang, B.B. Microrna miR-199a-3p regulates cell proliferation and survival by targeting caveolin-2. J. Cell Sci. 2011, 124, 2826-2836.
56. Migliore, C.; Petrelli, A.; Ghiso, E.; Corso, S.; Capparuccia, L.; Eramo, A.; Comoglio, P.M.; Giordano, S. Micrornas impair met-mediated invasive growth. Cancer Res. 2008, 68, 10128-10136.
57. Chen, A.; Luo, M.; Yuan, G.; Yu, J.; Deng, T.; Zhang, L.; Zhou, Y.; Mitchelson, K.; Cheng, J. Complementary analysis of microrna and mrna expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of hl-60 cells. Biotechnol. Lett. 2008, 30, 2045-2052.
58. Kang, S.G.; Lee, W.H.; Lee, Y.H.; Lee, Y.S.; Kim, S.G. Hypoxia-inducible factor-1alpha inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of micrornas 199a-5p and 20a induction. Carcinogenesis 2012, 33, 661-669.
59. Yu, T.; Wang, X.Y.; Gong, R.G.; Li, A.; Yang, S.; Cao, Y.T.; Wen, Y.M.; Wang, C.M.; Yi, X.Z. The expression profile of micrornas in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in syrian hamster. J. Exp. Clin. Cancer Res. 2009, 28, 64.
60. Burnside, J.; Ouyang, M.; Anderson, A.; Bernberg, E.; Lu, C.; Meyers, B.C.; Green, P.J.; Markis, M.; Isaacs, G.; Huang, E.; Morgan, R.W. Deep sequencing of chicken micrornas. BMC Genomics. 2008, 9, 185.
61. Liu, G.; Detloff, M.R.; Miller, K.N.; Santi, L.; Houle, J.D. Exercise modulates micrornas that affect the pten/mtor pathway in rats after spinal cord injury. Exp. Neurol. 2012, 233, 447-456.
62. Ogawa, T.; Enomoto, M.; Fujii, H.; Sekiya, Y.; Yoshizato, K.; Ikeda, K.; Kawada, N. Microrna-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Gut 2012, Epub ahead of print.
63. Murakami, Y.; Aly, H.H.; Tajima, A.; Inoue, I.; Shimotohno, K. Regulation of the hepatitis c virus genome replication by miR-199a. J. Hepatol. 2009, 50, 453-460.
64. Zhang, G.L.; Li, Y.X.; Zheng, S.Q.; Liu, M.; Li, X.; Tang, H. Suppression of hepatitis b virus replication by microrna-199a-3p and microrna-210. Antivir. Res. 2010, 88, 169-175.
65. Dolganiuc, A.; Petrasek, J.; Kodys, K.; Catalano, D.; Mandrekar, P.; Velayudham, A.; Szabo, G. Microrna expression profile in lieber-decarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol. Clin. Exp. Res. 2009, 33, 1704-1710.
66. Rane, S.; He, M.; Sayed, D.; Vashistha, H.; Malhotra, A.; Sadoshima, J.; Vatner, D.E.; Vatner, S.F.; Abdellatif, M. Downregulation of MiR-199a derepresses hypoxia-inducible factor-1alpha and sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ. Res. 2009, 104, 879-886.
67. Song, X.W.; Li, Q.; Lin, L.; Wang, X.C.; Li, D.F.; Wang, G.K.; Ren, A.J.; Wang, Y.R.; Qin, Y.W.; Yuan, W.J.; Jing, Q. Micrornas are dynamically regulated in hypertrophic hearts, and MiR-199a is essential for the maintenance of cell size in cardiomyocytes. J. Cell. Physiol. 2010, 225, 437-443.
68. Schneider, M.; Andersen, D.C.; Silahtaroglu, A.; Lyngbaek, S.; Kauppinen, S.; Hansen, J.L.; Sheikh, S.P. Cell-specific detection of microrna expression during cardiomyogenesis by combined in situ hybridization and immunohistochemistry. J. Mol. Histol. 2011, 42, 289-299.
69. Gonsalves, C.S.; Kalra, V.K. Hypoxia-mediated expression of 5-lipoxygenase-activating protein involves HIF-1alpha and NF-kappab and micrornas 135a and 199a-5p. J. Immunol. 2010, 184, 3878-3888.
70. Suomi, S.; Taipaleenmaki, H.; Seppanen, A.; Ripatti, T.; Vaananen, K.; Hentunen, T.; Saamanen, A.M.; Laitala-Leinonen, T. Micrornas regulate osteogenesis and chondrogenesis of mouse bone marrow stromal cells. Gene Regul. Syst. Biol. 2008, 2, 177-191.
71. Oskowitz, A.Z.; Lu, J.; Penfornis, P.; Ylostalo, J.; McBride, J.; Flemington, E.K.; Prockop, D.J.; Pochampally, R. Human multipotent stromal cells from bone marrow and microrna: Regulation of differentiation and leukemia inhibitory factor expression. Proc. Natl. Acad. Sci. USA 2008, 105, 18372-18377.
72. Akhtar, N.; Haqqi, T.M. Microrna-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes. Ann. Rheum. Dis. 2012, 71, 1073-1080.
73. Wang, K.H.; Kao, A.P.; Singh, S.; Yu, S.L.; Kao, L.P.; Tsai, Z.Y.; Lin, S.D.; Li, S.S. Comparative expression profiles of mrnas and micrornas among human mesenchymal stem cells derived from breast, face, and abdominal adipose tissues. Kaohsiung J. Med. Sci. 2010, 26, 113-122.
74. Alt, E.U.; Senst, C.; Murthy, S.N.; Slakey, D.P.; Dupin, C.L.; Chaffin, A.E.; Kadowitz, P.J.; Izadpanah, R. Aging alters tissue resident mesenchymal stem cell properties. Stem Cell Res. 2012, 8, 215-225.
75. Chen, B.Z.; Yu, S.L.; Singh, S.; Kao, L.P.; Tsai, Z.Y.; Yang, P.C.; Chen, B.H.; Shoei-Lung Li, S. Identification of micrornas expressed highly in pancreatic islet-like cell clusters differentiated from human embryonic stem cells. Cell Biol. Int. 2011, 35, 29-37.
76. Chakrabarty, A.; Tranguch, S.; Daikoku, T.; Jensen, K.; Furneaux, H.; Dey, S.K. Microrna regulation of cyclooxygenase-2 during embryo implantation. Proc. Natl. Acad. Sci. USA 2007, 104, 15144-15149.
77. Ben-Ami, O.; Pencovich, N.; Lotem, J.; Levanon, D.; Groner, Y. A regulatory interplay between MiR-27a and runx1 during megakaryopoiesis. Proc. Natl. Acad. Sci. USA 2009, 106, 238-243.
78. Lee, D.Y.; Shatseva, T.; Jeyapalan, Z.; Du, W.W.; Deng, Z.; Yang, B.B. A 3'-untranslated region (3'UTR) induces organ adhesion by regulating MiR-199a* functions. PLoS One 2009, 4, e4527.
79. Lee, D.Y.; Jeyapalan, Z.; Fang, L.; Yang, J.; Zhang, Y.; Yee, A.Y.; Li, M.; Du, W.W.; Shatseva, T.; Yang, B.B. Expression of versican 3'-untranslated region modulates endogenous microrna functions. PLoS One 2010, 5, e13599.
80. Kanda, T.; Ishibashi, O.; Kawahigashi, Y.; Mishima, T.; Kosuge, T.; Mizuguchi, Y.; Shimizu, T.; Arima, Y.; Yokomuro, S.; Yoshida, H.; et al. Identification of obstructive jaundice-related micrornas in mouse liver. Hepato-Gastroenterology 2010, 57, 1013-1023.
81. Dai, L.; Gu, L.; Di, W. MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKKβ/NF-kappab pathway and reduced interleukin-8 expression. Mol. Hum. Reprod. 2012, 18, 136-145.
82. Dai, L.; Gu, L.Y.; Zhu, J.; Shi, J.; Wang, Y.; Ji, F.; Di, W. Regulation of microrna-199a on adhesion, migration and invasion ability of human endometrial stromal cells. Zhonghua Fu Chan Ke Za Zhi 2011, 46, 817-821.
83. Cai, Z.G.; Zhang, S.M.; Zhang, Y.; Zhou, Y.Y.; Wu, H.B.; Xu, X.P. Micrornas are dynamically regulated and play an important role in lps-induced lung injury. Can. J. Physiol. Pharmacol. 2012, 90, 37-43.
84. Wu, J.H.; Gao, Y.; Ren, A.J.; Zhao, S.H.; Zhong, M.; Peng, Y.J.; Shen, W.; Jing, M.; Liu, L. Altered microrna expression profiles in retinas with diabetic retinopathy. Ophthalmic Res. 2011, 47, 195-201.
85. Xu, W.H.; Yao, X.Y.; Yu, H.J.; Huang, J.W.; Cui, L.Y. Downregulation of MiR-199a may play a role in 3-nitropropionic acid induced ischemic tolerance in rat brain. Brain Res. 2012, 1429, 116-123.
86. Choi, J.S.; Oh, J.H.; Park, H.J.; Choi, M.S.; Park, S.M.; Kang, S.J.; Oh, M.J.; Kim, S.J.; Hwang, S.Y.; Yoon, S. MiRna regulation of cytotoxic effects in mouse sertoli cells exposed to nonylphenol. Reprod. Biol. Endocrinol. 2011, 9, 126.
87. Park, H.A.; Kubicki, N.; Gnyawali, S.; Chan, Y.C.; Roy, S.; Khanna, S.; Sen, C.K. Natural vitamin E alpha-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke 2011, 42, 2308-2314.
88. Godwin, J.G.; Ge, X.; Stephan, K.; Jurisch, A.; Tullius, S.G.; Iacomini, J. Identification of a microrna signature of renal ischemia reperfusion injury. Proc. Natl. Acad. Sci. USA 2010, 107, 14339-14344.
89. Yang, M.H.; Wu, M.Z.; Chiou, S.H.; Chen, P.M.; Chang, S.Y.; Liu, C.J.; Teng, S.C.; Wu, K.J. Direct regulation of twist by hif-1alpha promotes metastasis. Nat. Cell Biol. 2008, 10, 295-305.