Biological monitoring for exposure to deltamethrin: A human oral dosing study and background levels in the UK general population

Toxicology Letters

Volumn 213, Issue 1, 2012, Pages 35-38

  Sams, C ^a   Jones, K ^a  

^a HEALTH AND SAFETY LABORATORY   (United Kingdom)

Author keywords

Biological monitoring; Deltamethrin; General population; Human volunteer study; Synthetic pyrethroid; Urine

Indexed keywords

3 (2,2 DIBROMOVINYL) 2,2 DIMETHYL (1 CYCLOPROPANE)CARBOXYLIC ACID; 3 PHENOXYBENZOIC ACID; CREATININE; DELTAMETHRIN; INSECTICIDE; PYRETHROID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOLOGICAL MONITORING; ENVIRONMENTAL EXPOSURE; FEMALE; GAS CHROMATOGRAPHY; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; METABOLITE; OCCUPATIONAL EXPOSURE; POPULATION RESEARCH; PRIORITY JOURNAL; UNITED KINGDOM; URINE LEVEL;

ADMINISTRATION, ORAL; ADULT; CREATININE; ENVIRONMENTAL EXPOSURE; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GREAT BRITAIN; HALF-LIFE; HUMANS; INSECTICIDES; MALE; MIDDLE AGED; NITRILES; PYRETHRINS; YOUNG ADULT;

EID: 84864321475     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.04.014     Document Type: Article

References (20)

1. Angerer J., Ritter A. Determination of metabolites of pyrethroids in human urine using solid-phase extraction and gas chromatography-mass spectrometry. J. Chromatogr. B: Biomed. Sci. Appl. 1997, 695:217-226.
2. Bradberry S.M., Cage S.A., Proudfoot A.T., Vale J.A. Poisoning due to pyrethroids. Toxicol. Rev. 2005, 24:93-106.
3. Butler A.R. The Jaffe reaction. Identification of the coloured species. Clin. Chim. Acta 1975, 59:227-232.
4. Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment Risk Assessment of Mixtures of Pesticides and Similar Substances. September 2002 2002, http://www.food.gov.uk/science/ouradvisors/toxicity/reports/cocktailreport.
5. Garfitt S.J., Jones K., Mason H.J., Cocker J. Exposure to the organophosphate diazinon: data from a human volunteer study with oral and dermal doses. Toxicol. Lett. 2002, 134:105-113.
6. Griffin P., Mason H., Heywood K., Cocker J. Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occup. Environ. Med. 1999, 56:10-13.
7. Hardt J., Angerer J. Biological monitoring of workers after the application of insecticidal pyrethroids. Int. Arch. Occup. Environ. Health 2003, 76:492-498.
8. Heudorf U., Angerer J. Metabolites of pyrethroid insecticides in urine specimens: current exposure in an urban population in Germany. Environ. Health Perspect. 2001, 109:213-217.
9. JMPR 580. Deltamethrin (Pesticide Residues in Food: 1982 Evaluations) 1982, http://www.inchem.org/documents/jmpr/jmpmono/v82pr12.htm.
10. JMPR Pesticide Residues in Food 2000: Deltamethrin 2000, http://www.inchem.org/documents/jmpr/jmpmono/v00pr04.htm.
11. Leng G., Ranft U., Sugiri D., Hadnagy W., Berger-Preiss E., Idel H. Pyrethroids used indoors-biological monitoring of exposure to pyrethroids following an indoor pest control operation. Int. J. Hyg. Environ. Health 2003, 206:85-92.
12. Levy L.S., Jones K., Cocker J., Assem F.L., Capleton A.C. Background levels of key biomarkers of chemical exposure within the UK general population-Pilot study. Int. J. Hyg. Environ. Health 2007, 210:387-391.
13. NHANES Fourth National Report on Human Exposure to Environmental Chemicals 2009, Department of Health and Human Services Centers for Disease Control and Prevention. http://www.cdc.gov/exposurereport/pdf/FourthReport.pdf.
14. Ray D.E., Forshaw P.J. Pyrethroid insecticides: poisoning syndromes, synergies, and therapy. J. Toxicol. Clin. Toxicol. 2000, 38:95-101.
15. Sams C., Patel K., Jones K. Biological monitoring for exposure to pirimicarb: method development and a human oral dosing study. Toxicol. Lett. 2010, 192:56-60.
16. Soderlund D.M., Clark J.M., Sheets L.P., Mullin L.S., Piccirillo V.J., Sargent D., Stevens J.T., Weiner M.L. Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 2002, 171:3-59.
17. Tuomainen A., Kangas J., Liesivuori J., Manninen A. Biological monitoring of deltamethrin exposure in greenhouses. Int. Arch. Occup. Environ. Health 1996, 69:62-64.
18. Wang D., Kamijima M., Imai R., Suzuki T., Kameda Y., Asai K., Okamura A., Naito H., Ueyama J., Saito I., Nakajima T., Goto M., Shibata E., Kondo T., Takagi K., Takagi K., Wakusawa S. Biological monitoring of pyrethroid exposure of pest control workers in Japan. J. Occup. Health 2007, 49:509-514.
19. Woollen B.H., Marsh J.R., Laird W.J.D., Lesser J.E. The metabolism of cypermethrin in man-differences in urinary metabolite profiles following oral and dermal administration. Xenobiotica 1992, 22:983-991.
20. Yao P.P., Li Y.W., Ding Y.Z., He F. Biological monitoring of deltamethrin in sprayers by HPLC method. J. Hyg. Epidemiol. Microbiol. Immunol. 1992, 36:31-36.