Validation of FRC, a Fracture Risk Assessment Tool, in a Cohort of Older Men: The Osteoporotic Fractures in Men (MrOS) Study

Journal of Clinical Densitometry

Volumn 15, Issue 3, 2012, Pages 334-342

  Ettinger, Bruce ^a,b   Liu, Hau ^c   Blackwell, Terri ^d   Hoffman, Andrew R ^c   Ensrud, Kristine E ^e,f   Orwoll, Eric S ^g  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DIVISION OF RESEARCH   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^e VA MEDICAL CENTER   (United States)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Fracture; Men; Prediction; Risk assessment

Indexed keywords

ADULT; AGED; ARTICLE; BONE MINERAL; CLINICAL ASSESSMENT TOOL; FOLLOW UP; FOREARM FRACTURE; FRACTURE RISK CALCULATOR; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; RISK ASSESSMENT; SHOULDER FRACTURE; SPINE FRACTURE;

AGED; AGED, 80 AND OVER; COHORT STUDIES; HIP FRACTURES; HUMANS; MALE; MIDDLE AGED; OSTEOPOROTIC FRACTURES; RISK ASSESSMENT; RISK FACTORS; ROC CURVE;

EID: 84864319253     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2012.01.011     Document Type: Article

References (31)

1. Lo J.C., Pressman A.R., Chandra M., Ettinger B. Fracture risk tool validation in an integrated healthcare delivery system. Am J Manag Care 2011, 17(3):188-194.
2. Kanis J.A., Oden A., Johnell O., et al. The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women. Osteoporos Int 2007, 18(8):1033-1046.
3. FRAX. Available at: Accessed December 1, 2011. http://www.shef/ac/uk/FRAX/.
4. FORE 10-year fracture risk calculator for health care professionals Available at:. Accessed December 1, 2011. http://riskcalculator.fore.org/.
5. Dawson-Hughes B. A revised clinician's guide to the prevention and treatment of osteoporosis. J Clin Endocrinol Metab 2008, 93(7):2463-2465.
6. Guideline for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the U.K. National Osteoporosis Guideline Group (NOGG); Available at: Accessed December 1, 2011. http://www.sheffield.ac.uk/NOGG/downloads.html.
7. Schwartz A.V., Vittinghoff E., Bauer D.C., et al. Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA 2011, 305(21):2184-2192. Study of Osteoporotic Fractures (SOF) Research Group, Osteoporotic Fractures in Men (MrOS) Research GroupOsteoporotic Fractures in Men (MrOS) Research Group, Health, Aging, and Body Composition (Health ABC) Research GroupHealth, Aging, and Body Composition (Health ABC) Research Group.
8. Berry S.D., Kiel D.P., Donaldson M.G., et al. Application of the National Osteoporosis Foundation Guidelines to postmenopausal women and men: the Framingham Osteoporosis Study. Osteoporos Int 2010, 21(1):53-60.
9. Feldstein A.C., Nichols G., Orwoll E., et al. The near absence of osteoporosis treatment in older men with fractures. Osteoporos Int 2005, 16(8):953-962.
10. Orwoll E., Blank J.B., Barrett-Connor E., et al. Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study-a large observational study of the determinants of fracture in older men. Contemp Clin Trials 2005, 26(5):569-585.
11. Blank J.B., Cawthon P.M., Carrion-Petersen M.L., et al. Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials 2005, 26:557-568.
12. Ettinger B., Hillier T.A., Pressman A., et al. Simple computer model for calculating and reporting 5-year osteoporotic fracture risk in postmenopausal women. J Womens Health 2005, 14:159-171.
13. National Osteoporosis Foundation Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis: Status Report. Osteoporos Int 1998, 8(Suppl 4):1-128.
14. Ettinger B., Black D.M., Dawson-Hughes B., et al. Updated fracture incidence rates for the US version of FRAX. Osteoporos Int 2010, 21(1):25-33.
15. Tosteson A.N., Melton L.J., Dawson-Hughes B., et al. Cost-effective osteoporosis treatment thresholds: the United States perspective. Osteoporos Int 2008, 19(4):437-447.
16. Looker A.C., Wahner H.W., Dunn W.L., et al. Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 1998, 8(5):468-489.
17. Pahor M., Chrischilles E.A., Guralnik J.M., et al. Drug data coding and analysis in epidemiologic studies. Eur J Epidemiol 1994, 10(4):405-411.
18. Cummings S.R., Cawthon P.M., Ensrud K.E., et al. BMD and risk of hip and nonvertebral fractures in older men: a prospective study and comparison with older women. J Bone Miner Res 2006, 21(10):1550-1556. Osteoporotic fractures in men (MrOS) Research Groups, Study of Osteoporotic Fractures Research GroupsStudy of Osteoporotic Fractures Research Groups.
19. Mackey D.C., Lui L.Y., Cawthon P.M., et al. High-trauma fractures and low bone mineral density in older women and men. JAMA 2007, 298(20):2381-2388.
20. Pencina M.J., D'Agostino R.B., Steyerberg E.W. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med 2011, 30(1):11-21.
21. Cook N.R. Use and misuse of the receiver operating characteristic curve in risk prediction. Circulation 2007, 115(7):928-935.
22. Cook N.R., Ridker P.M. Advances in measuring the effect of individual predictors of cardiovascular risk: the role of reclassification measures. Ann Intern Med 2009, 150(11):795-802.
23. Pencina M.J., D'Agostino R.B., D'Agostino R.B., Vasan R.S. Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med 2008, 27(2):157-172.
24. Sornay-Rendu E., Munoz F., Delmas P.D., Chapurlat R.D. The FRAX tool in French women: how well does it describe the real incidence of fracture in the OFELY cohort?. J Bone Miner Res 2010, 25(10):2101-2107.
25. Bolland M.J., Siu A.T., Mason B.H., et al. Evaluation of the FRAX and Garvan fracture risk calculators in older women. J Bone Miner Res 2011, 26(2):420-427.
26. Sandhu S.K., Nguyen N.D., Center J.R., et al. Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int 2010, 21(5):863-871.
27. Ensrud K.E., Lui L.Y., Taylor B.C., et al. A comparison of prediction models for fractures in older women: is more better?. Arch Intern Med 2009, 169(22):2087-2094.
28. Pressman A.R., Lo J.C., Chandra M., Ettinger B. Methods for Assessing Fracture Risk Prediction Models: experience with FRAX in a large integrated healthcare delivery system. J Clin Densitom 2011, 14(4):407-415.
29. Donaldson M.G., Cawthon P.M., Schousboe J.T., et al. Novel methods to evaluate fracture risk models. J Bone Miner Res 2011, 26(8):1767-1773.
30. Hippisley-Cox J., Coupland C. Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation and validation of QFracture Scores. BMJ 2009, 339:b4229.
31. Leslie W.D., Lix L.M., Johansson H., et al. Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res 2010, 25(11):2350-2358. Manitoba Bone Density Program.