Optical sensor enabled rocking T-flasks as novel upstream bioprocessing tools

Biotechnology and Bioengineering

Volumn 109, Issue 9, 2012, Pages 2295-2305

  Vallejos, Jose R ^a,d   Micheletti, Martina ^b   Brorson, Kurt A ^c   Moreira, Antonio R ^a   Rao, Govind ^a  

^a Baltimore County   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d DSM RESOLVE   (Netherlands)

Author keywords

Disposable bioreactors; Mass transfer; Optical sensors; Scale down; Seed train; T flasks

Indexed keywords

BIOPROCESSING; CELL DENSITY; CONVECTION AND DIFFUSION; CULTURE VESSEL; EMPIRICAL CORRELATIONS; HYDRODYNAMIC STRESS; LABORATORY SCALE; NEGATIVE CORRELATION; ONLINE MONITORING; OXYGEN TRANSFER; SCALE-DOWN; SEED CULTURES; SPINNER FLASKS; T-FLASKS; VOLUMETRIC MASS TRANSFER COEFFICIENT;

BIOREACTORS; CELL CULTURE; INDUSTRIAL RESEARCH; MASS TRANSFER; OPTICAL SENSORS; OXYGEN; VOLUMETRIC ANALYSIS;

BOTTLES;

ANIMAL CELL; ARTICLE; BIOPROCESS; BIOSENSOR; CELL CULTURE; CELL DENSITY; CELL GROWTH; HYDRODYNAMICS; NONHUMAN; OPTICAL SENSOR ENABLED ROCKING T FLASK; PH;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; CELL CULTURE TECHNIQUES; CULTURE MEDIA; GLUCOSE; HYBRIDOMAS; IMMUNOGLOBULIN G; MICE; OPTICS AND PHOTONICS; TIME FACTORS;

EID: 84864309757     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24508     Document Type: Article

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