Acid sphingomyelinase deficiency contributes to resistance of scleroderma fibroblasts to Fas-mediated apoptosis

Journal of Dermatological Science

Volumn 67, Issue 3, 2012, Pages 166-172

  Samuel, Glady Hazitha ^a   Lenna, Stefania ^a   Bujor, Andreea M ^a   Lafyatis, Robert ^a   Trojanowska, Maria ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Fas ligand; Fibrosis; Myofibroblast; Systemic sclerosis

Indexed keywords

ADENOVIRUS VECTOR; FAS ANTIBODY; FAS ANTIGEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; SMALL INTERFERING RNA; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSFORMING GROWTH FACTOR BETA;

APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME DEFICIENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FIBROBLAST; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCLERODERMA; SPHINGOMYELIN PHOSPHODIESTERASE DEFICIENCY; WESTERN BLOTTING;

ANTIGENS, CD95; APOPTOSIS; CYTOKINES; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FIBROSIS; HUMANS; MYOFIBROBLASTS; NIEMANN-PICK DISEASE, TYPE A; OLIGONUCLEOTIDES; PROTEIN PHOSPHATASE 2; RNA INTERFERENCE; RNA, SMALL INTERFERING; SCLERODERMA, SYSTEMIC; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 84864307975     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2012.06.001     Document Type: Article

References (31)

1. Wynn T.A. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 2007, 117:524-529.
2. Wynn T.A. Cellular and molecular mechanisms of fibrosis. J Pathol 2008, 214:199-210.
3. Darby I.A., Hewitson T.D. Fibroblast differentiation in wound healing and fibrosis. Int Rev Cytol 2007, 257:143-179.
4. Desmouliere A. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 1995, 19:471-476.
5. Barrientos S., Stojadinovic O., Golinko M.S., Brem H., Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen 2008, 16:585-601.
6. Hantash B.M., Zhao L., Knowles J.A., Lorenz H.P. Adult and fetal wound healing. Front Biosci 2008, 13:51-61.
7. Desmouliere A., Darby I.A., Gabbiani G. Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest 2003, 83:1689-1707.
8. Varga J., Abraham D. Systemic sclerosis: a prototypic multisystem fibrotic disorder. J Clin Invest 2007, 117:557-567.
9. Ihn H. Autocrine TGF-beta signaling in the pathogenesis of systemic sclerosis. J Dermatol Sci 2008, 49:103-113.
10. Querfeld C., Eckes B., Huerkamp C., Krieg T., Sollberg S. Expression of TGF-beta 1, -beta 2 and -beta 3 in localized and systemic scleroderma. J Dermatol Sci 1999, 21:13-22.
11. Kawakami T., Ihn H., Xu W., Smith E., LeRoy C., Trojanowska M. Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype. J Invest Dermatol 1998, 110:47-51.
12. Iredale J.P., Benyon R.C., Pickering J., McCullen M., Northrop M., Pawley S., et al. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 1998, 102:538-549.
13. Saile B., Knittel T., Matthes N., Schott P., Ramadori G. Cd95/cd95l-mediated apoptosis of the hepatic stellate cell. A mechanism terminating uncontrolled hepatic stellate cell proliferation during hepatic tissue repair. Am J Pathol 1997, 151:1265-1272.
14. Santiago B., Galindo M., Rivero M., Pablos J.L. Decreased susceptibility to fas-induced apoptosis of systemic sclerosis dermal fibroblasts. Arthritis Rheum 2001, 44:1667-1676.
15. Jelaska A., Korn J.H. Role of apoptosis and transforming growth factor beta1 in fibroblast selection and activation in systemic sclerosis. Arthritis Rheum 2000, 43:2230-2239.
16. Kawakami A., Eguchi K., Matsuoka N., Tsuboi M., Kawabe Y., Aoyagi T., et al. Inhibition of fas antigen-mediated apoptosis of rheumatoid synovial cells in vitro by transforming growth factor beta 1. Arthritis Rheum 1996, 39:1267-1276.
17. Smith E.L., Schuchman E.H. The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J 2008, 22:3419-3431.
18. Gulbins E., Grassme H. Ceramide and cell death receptor clustering. Biochim Biophys Acta 2002, 1585:139-145.
19. Cremesti A., Paris F., Grassme H., Holler N., Tschoppo J., Fuks Z., et al. Ceramide enables fas to cap and kill. J Biol Chem 2001, 276:23954-23961.
20. Grassme H., Jekle A., Riehle A., Schwarz H., Berger J., Sandhoff K., et al. Cd95 signaling via ceramide-rich membrane rafts. J Biol Chem 2001, 276:20589-20596.
21. Samuel G.H., Bujor A.M., Nakerakanti S.S., Hant F.N., Trojanowska M. Autocrine transforming growth factor beta signaling regulates extracellular signal-regulated kinase 1/2 phosphorylation via modulation of protein phosphatase 2a expression in scleroderma fibroblasts. Fibrogenesis Tissue Repair 2010, 3:25.
22. Pannu J., Nakerakanti S., Smith E., ten Dijke P., Trojanowska M. Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of SMAD1 and ERK1/2 pathways. J Biol Chem 2007, 282:10405-10413.
23. He T.C., Zhou S., da Costa L.T., Yu J., Kinzler K.W., Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 1998, 95:2509-2514.
24. Dobrowsky R.T., Kamibayashi C., Mumby M.C., Hannun Y.A. Ceramide activates heterotrimeric protein phosphatase 2a. J Biol Chem 1993, 268:15523-15530.
25. Chung H., Nairn A.C., Murata K., Brautigan D.L. Mutation of tyr307 and leu309 in the protein phosphatase 2a catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry 1999, 38:10371-10376.
26. Brautigan D.L. Flicking the switches: phosphorylation of serine/threonine protein phosphatases. Semin Cancer Biol 1995, 6:211-217.
27. Ruvolo P.P. Ceramide regulates cellular homeostasis via diverse stress signaling pathways. Leukemia 2001, 15:1153-1160.
28. Kim S.W., Kim H.J., Chun Y.J., Kim M.Y. Ceramide produces apoptosis through induction of p27 (kip1) by protein phosphatase 2a-dependent akt dephosphorylation in pc-3 prostate cancer cells. J Toxicol Environ Health A 2010, 73:1465-1476.
29. Park M.A., Mitchell C., Zhang G., Yacoub A., Allegood J., Haussinger D., et al. Vorinostat and sorafenib increase cd95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-pp2a-reactive oxygen species-dependent signaling pathway. Cancer Res 2010, 70:6313-6324.
30. Ruvolo P.P., Deng X., Ito T., Carr B.K., May W.S. Ceramide induces bcl2 dephosphorylation via a mechanism involving mitochondrial pp2a. J Biol Chem 1999, 274:20296-20300.
31. 2+-dependent cell survival and death. Mol Cell 2009, 33:377-388.