Ceramide produces apoptosis through induction of p27kip1 by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 21-22, 2010, Pages 1465-1476

  Kim, Sang Woo ^a   Kim, Hae Jong ^b   Chun, Young Jin ^a   Kim, Mie Young ^a  

^a Chung Ang University   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1B; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; S PHASE KINASE ASSOCIATED PROTEIN 2; SMALL INTERFERING RNA; CDKN1B PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 2; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; DOWN REGULATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; UPREGULATION; BIOSYNTHESIS; CELL CYCLE; DRUG EFFECTS; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATIC NEOPLASMS; TOXICITY; TUMOR CELL LINE;

APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CERAMIDES; CYCLIN-DEPENDENT KINASE INHIBITOR P27; GENE SILENCING; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 77958168429     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2010.511553     Document Type: Article

References (40)

1. Kip1 degradation and proliferation of chronic myelogenous leukemia cells. Cancer Res. 65:3264-3272.
2. Kip1 in prostate cancer. J. Urol. 170:241-245.
3. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868.
4. Carrano, A. C., Eytan, R. E., Hershko, A., and Pagano, M. 1999. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat. Cell. Biol. 1:193-199.
5. Dawson, J. F., and Holmes, C. F. 1999. Molecular mechanisms underlying inhibition of protein phosphatases by marine toxins. Front. Biosci. 4: D646-D658.
6. Ekholm, S. V., and Reed, S. I. 2000. Regulation of G1 cyclin-dependent kinases in the mammalian cell cycle. Curr. Opin. Cell Biol. 12:676-684.
7. Fernández, J. J., Candenas, M. L., Souto, M. L., Trujillo, M. M., and Norte, M. 2002. Okadaic acid, useful tool for studying cellular processes. Curr. Med. Chem. 9:229-262.
8. Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J. Biol. Chem. 277:28706-28713.
9. Kip1 expression. J. Biol. Chem. 275:24500-24505.
10. Han, J. H., Choi, C. S., Kim, M. Y., and Chun, Y. J. 2007. Differential gene expression by styrene in rat reproductive tissue. J. Toxicol. Environ. Health A 70:1259-1263.
11. Hannun, Y. A. 1996. Functions of ceramide in coordinating cellular responses to stress. Science 274:1855-1859.
12. Janssens, V., and Goris, J. 2001. Protein phosphatase 2A: A highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem. J. 353:417-439.
13. Janssens, V., Goris, J., and Van Hoof, C. 2005. PP2A: The expected tumor suppressor. Curr. Opin. Genet. Dev. 15:34-41.
14. Kim, H. J., Mun, J. Y., Chun, Y. J., Choi, K. H., and Kim, M. Y. 2001. Bax-dependent apoptosis induced by ceramide in HL-60 cells. FEBS Lett. 505:264-268.
15. kip1 in ceramide-mediated apoptosis in HL-60 cells. Cancer Lett. 151:39-48.
16. Law, B., and Rossie, S. 1995. The dimeric and catalytic subunit forms of protein phosphatase 2A from rat brain are stimulated by C2-ceramide. J. Biol Chem. 270:12808-12813.
17. Lee, J. G., and Kay, E. P. 2007. Two populations of p27 use differential kinetics to phosphorylate Ser-10 and Thr-187 via phosphatidylinositol 3-kinase in response to fibroblast growth factor-2 stimulation. J. Biol. Chem. 282:6444-6454.
18. Lee, S. K., Kim, Y., Kim, M. Y., Chun, Y. J., and Kim, S. 2004. Potent inhibition of recombinant human cytochrome P-450 1A1 by pentamethoxystilbene. J. Toxicol. Environ. Health A 67:1987-2000. (Pubitemid 39488868)
19. kip1: A multifunctional cyclindependent kinase inhibitor with prognostic significance in human cancers. Am. J. Pathol. 154:313-323.
20. Matias, W. G., Bonini, M., and Creppy, E. E. 1996. Inhibition of protein synthesis in a cellfree system and Vero cells by okadaic acid, a diarrhetic shellfish toxin. J. Toxicol. Environ. Health A 48:309-317.
21. kip1. Nature 404:782-787.
22. Millward, T. A., Zoinierowicz, S., and Hemmings, B. A. 1999. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24:186-191.
23. Montagnoli, A., Fiore, F., Eytan, E., Carrano, A. C., Draetta, G. F., Hershko, A., and Pagano, M. 1999. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 13:1181-1189.
24. Kip1 expression and localization. Am. J. Pathol. 166:737-749.
25. Obeid, L. M., Linardic, C. M., Karolak, L. A., and Hannun, Y. A. 1993. Programmed cell death by ceramide. Science 259:1769-1771.
26. Oh, W. J., Kim, W. H., Kang, K. H., Kim, T. Y., Kim, M. Y., and Choi, K. H. 1998. Induction of p21 during ceramide-mediated apoptosis in human hepatocarcinoma cells. Cancer Lett. 129:215-222.
27. Pagano, M., Tam, S. W., Theodoras, A. M., Beer-Romero, P., Del Sal, G., Chau, V., Yew, P. R., Draetta, G. F., and Rolfe, M. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685.
28. Pettus, B., Chalfant, C. E., and Hannun, Y. A. 2002. Ceramide in apoptosis: An overview and current perspectives. Biochem. Biophys. Acta 1585:114-125.
29. Reichert, M., Saur, D., Hamacher, R., Schmid, R. M., and Schneider, G. 2007. Phosphoinositide-3-kinase signaling controls S-Phase Kinase-Associated protein 2 transcription via E2F-1 in pancreatic ductal adenocarcinoma cells. Cancer Res. 67:4149-4156.
30. Ruvolo, P. P., Deng, X., Ito, T., Carr, B. K., and May, W. S. 1999. Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 274:20296-20300.
31. Kip1 at Thr-157 interferes with its association with importin α during G1 and prevents nuclear re-entry. J. Biol. Chem. 280:6055-6063.
32. Kip1 at threonine 157 and modulation of its cellular localization. Nat. Med. 8:1145-1152.
33. Slingerland, J., and Pagano, M. 2000. Regulation of the cdk inhibitor p27 and its deregulation in cancer. J. Cell. Physiol. 183:10-17.
34. Son, J. H., Yoo, H. H., and Kim, D. H. 2007. Activation of de novo synthetic pathway of ceramides is responsible for the initiation of hydrogen peroxide-induced apoptosis in HL-60 cells. J. Toxicol. Environ. Health A 70:1310-1318.
35. Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. Cancer Res. 58:542-548.
36. Kip1 regulation in LNCaP and PC346 cells. Prostate 66:749-760.
37. kip by PKB/Akt-mediated phosphorylation in breast cancer. Nat. Med. 8:1136-1144.
38. Xin, M., and Deng, X. 2006. Protein phosphatase 2A enhances the proapotpotic function of Bax through dephosphorylation. J. Biol. Chem. 281:18859-18866.
39. Yin, K. J., Hsu, C. Y., Hu, X. Y., Chen, H., Chen, S. W., Xu, J., and Lee, J. M. 2006. Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death. J. Neurosci. 26:2290-2299.
40. L. Cell 87:619-628.