Abnormal left-sided orbitomedial prefrontal cortical-amygdala connectivity during happy and fear face processing: A potential neural mechanism of female MDD

Frontiers in Psychiatry

Volumn 2, Issue DEC, 2011, Pages

  De Almeida, Jorge Renner Cardoso ^a   Kronhaus, Dina Michaela ^b   Sibille, Etienne L ^a   Langenecker, Scott A ^c   Versace, Amelia ^a   LaBarbara, Edmund James ^a   Phillips, Mary Louise ^a,d  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Amygdala; Dynamic causal modeling; Effective connectivity; Emotion regulation; Major depressive disorder; Prefrontal cortex

Indexed keywords

ABNORMAL INCREASED POSITIVE LEFT SIDED SUBGENUAL CINGULATE CORTICAL AMYGDALA CONNECTIVITY; ABNORMAL INVERSE LEFT SIDED SUBGENUAL CINGULATE CORTICAL AMYGDALA CONNECTIVITY; ABNORMAL INVERSE LEFT SIDED TOP DOWN VENTROMEDIAL PREFRONTAL CORTICAL AMYGDALA CONNECTIVITY; ABNORMAL INVERSE LEFT SIDED VENTROMEDIAL PREFRONTAL CORTICAL AMYGDALA CONNECTIVITY; ABNORMAL LEFT SIDED ORBITOMEDIAL PREFRONTAL CORTICAL AMYGDALA CONNECTIVITY; ABNORMAL REDUCED POSITIVE LEFT SIDED VENTROMEDIAL PREFRONTAL CORTICAL SUBGENUAL CINGULATE CORTICAL CONNECTIVITY; ADULT; AMYGDALOID NUCLEUS; ANGER; ANXIETY; ARTICLE; CLINICAL ARTICLE; COMORBIDITY; CONNECTOME; CONTROLLED STUDY; EMOTION; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; HAPPINESS; HUMAN; INCREASED POSITIVE LEFT SIDED SUBGENUAL CINGULATE CORTEX AMYGDALA CONNECTIVITY; INTERPERSONAL STRESS; INVERSE LEFT SIDED SUBGENUAL CINGULATE CORTICAL AMYGDALA CONNECTIVITY; INVERSE LEFT SIDED VENTROMEDIAL PREFRONTAL CORTICAL AMYGDALA CONNECTIVITY; LEFT SIDED VENTROMEDIAL PREFRONTAL CORTICAL SUBGENUAL CINGULATE CORTICAL CONNECTIVITY; MAJOR DEPRESSION; MALE; MEDICAL HISTORY; NERVE CELL NETWORK; NEUROANATOMY; NEUROPATHOLOGY; NEUROPHYSIOLOGY; PREFRONTAL CORTEX; REDUCED POSITIVE LEFT SIDED VENTROMEDIAL PREFRONTAL CORTICAL SUBGENUAL CINGULATE CORTEX CONNECTIVITY; SAD; SEX DIFFERENCE; SUBGENUAL CINGULATE CORTEX; SUBGENUAL CINGULATE CORTICAL AMYGDALA CONNECTIVITY; TASK PERFORMANCE; VENTROMEDIAL PREFRONTAL CORTEX; VENTROMEDIAL PREFRONTAL CORTICAL AMYGDALA CONNECTIVITY;

EID: 84864303527     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2011.00069     Document Type: Article

References (83)

1. Abler, B., Erk, S., Herwig, U., and Walter, H. (2007). Anticipation of aversive stimuli activates extended amygdala in unipolar depression. J. Psychiatr. Res. 41, 511-522.
2. Almeida, J. R., Akkal, D., Hassel, S., Travis, M. J., Banihashemi, L., Kerr, N., Kupfer, D. J., and Phillips, M. L. (2009a). Reduced gray matter volume in ventral prefrontal cortex but not amygdala in bipolar disorder: significant effects of gender and trait anxiety. Psychiatry Res. 171, 54-68.
3. Almeida, J. R., Mechelli, A., Hassel, S., Versace, A., Kupfer, D. J., and Phillips, M. L. (2009b). Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder. Psychiatry Res. 174, 195-201.
4. Almeida, J. R., Versace, A., Mechelli, A., Hassel, S., Quevedo, K., Kupfer, D. J., and Phillips, M. L. (2009c). Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression. Biol. Psychiatry 66, 451-459.
5. Almeida, J. R. C., Phillips, M. L., Cerqueira, C. T., Zilberman, M., Lobo, D., Henna, E., Tavares, H., Amaro, E., Gorenstein, C., Gentil, V., and Busatto, G. F. (2010a). Neural activity changes to emotional stimuli in healthy individuals under chronic use of clomipramine. J. Psychopharmacol. (Oxford) 24, 1165-1174.
6. Almeida, J. R. C., Versace, A., Hassel, S., Kupfer, D. J., and Phillips, M. L. (2010b). Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression. Biol Psychiatry 67, 414-421.
7. Anand, A., Li, Y., Wang, Y., Gardner, K., and Lowe, M. J. (2007). Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. J. Neuropsychiatry Clin. Neurosci. 19, 274-282.
8. Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., and Lowe, M. J. (2005). Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry 57, 1079-1088.
9. APA. (2000). Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR. Washington, DC: American Psychiatric Association.
10. Beevers, C. G., Clasen, P., Stice, E., and Schnyer, D. (2010). Depression symptoms and cognitive control of emotion cues: a functional magnetic resonance imaging study. Neuroscience 167, 97-103.
11. Bremner, J. D., Vythilingam, M., Vermetten, E., Nazeer, A., Adil, J., Khan, S., Staib, L. H., and Charney, D. S. (2002). Reduced volume of orbitofrontal cortex in major depression. Biol Psychiatry 51, 273-279.
12. Brockmann, H., Zobel, A., Joe, A., Biermann, K., Scheef, L., Schuhmacher, A., Von Widdern, O., Metten, M., Biersack, H. J., Maier, W., and Boecker, H. (2009). The value of HMPAO SPECT in predicting treatment response to citalopram in patients with major depression. Psychiatry Res. 173, 107-112.
13. Carvajal-Rodriguez, A., De Una-Alvarez, J., and Rolan-Alvarez, E. (2009). A new multitest correction (SGoF) that increases its statistical power when increasing the number of tests. BMC Bioinformatics 10, 209. doi:10.1186/1471-2105-10-209
14. Chen, C. H., Suckling, J., Ooi, C., Fu, C. H., Williams, S. C., Walsh, N.D., Mitterschiffthaler, M. T., Pich, E. M., and Bullmore, E. (2008). Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology 33, 1909-1918.
15. Dannlowski, U., Ohrmann, P., Bauer, J., Deckert, J., Hohoff, C., Kugel, H., Arolt, V., Heindel, W., Kersting, A., Baune, B. T., and Suslow, T. (2008). 5-HTTLPR biases amygdala activity in response to masked facial expressions in major depression. Neuropsychopharmacology 33, 418-424.
16. Dannlowski, U., Ohrmann, P., Bauer, J., Kugel, H., Arolt, V., Heindel, W., and Suslow, T. (2007). Amygdala reactivity predicts automatic negative evaluations for facial emotions. Psychiatry Res. 154, 13-20.
17. Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., Hohoff, C., Schoning, S., Kersting, A., Baune, B. T., Mortensen, L. S., Arolt, V., Zwitserlood, P., Deckert, J., Heindel, W., and Suslow, T. (2009). Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity. Int. J. Neuropsychopharmacol. 12, 11-22.
18. David, O., Guillemain, I., Saillet, S., Reyt, S., Deransart, C., Segebarth, C., and Depaulis, A. (2008). Identifying neural drivers with functional MRI: an electrophysiological validation. PLoSBiol. 6, e315. doi:10.1371/journal.pbio.0060315
19. Davidson, R. J., Ekman, P., Saron, C. D., Senulis, J. A., and Friesen, W V. (1990). Approach-withdrawal and cerebral asymmetry: emotional expression and brain physiology. I. J. Pers. Soc. Psychol. 58, 330-341.
20. Davis, J. M., and Chen, N. (2004). Dose response and dose equivalence of antipsychotics. J. Clin. Psychopharmacol. 24, 192-208.
21. Drevets, W C. (2001). Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr. Opin. Neurobiol. 11, 240-249.
22. Fales, C. L., Barch, D. M., Rundle, M. M., Mintun, M. A., Snyder, A. Z., Cohen, J. D., Mathews, J., and Sheline, Y. I. (2008). Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biol. Psychiatry 63, 377-384.
23. First, M. B., Spitzer, R. L., Gibbon, M., and Willians, J. B. W. (1995). Structured Clinical Interview for DSM-W Axis I Disorders (SCID-, version [0).] New York: Biometric research Department, New York State Psychiatric Institute.
24. Friston, K. J., Harrison, L., and Penny, W. (2003). Dynamic causal modelling. Neuroimage 19, 1273-1302.
25. Frodl, T., Bokde, A. L. W., Scheuerecker, J., Lisiecka, D., Schoepf, V., Hampel, H., Möller, H.-J., Brückmann, H., Wiesmann, M., and Meisenzahl, E. (2010). Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression. Biol. Psychiatry 67, 161-167.
26. Fu, C. H., Williams, S. C., Brammer, M. J., Suckling, J., Kim, J., Cleare, A. J., Walsh, N. D., Mitterschiffthaler, M. T., Andrew, C. M., Pich, E. M., and Bullmore, E. T. (2007). Neural responses to happy facial expressions in major depression following anti depressant treatment. Am. J. Psychiatry 164, 599-607.
27. Gillath, O., Bunge, S. A., Shaver, P. R., Wendelken, C., and Mikulincer, M. (2005). Attachment-style differences in the ability to suppress negative thoughts: exploring the neural correlates. Neuroimage 28, 835-847.
28. Goodwin, F. K., and Jamison, K. R. (2007). Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression. New York, NY: Oxford University Press.
29. Gottfried, J. A., and Dolan, R. J. (2004). Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value. Nat. Neurosci. 7, 1144-1152.
30. Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., and Schatzberg, A. F. (2007). Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus. Biol. Psychiatry 62, 429-437.
31. Grober, E., and Sliwinski, M. (1991). Development and validation of a model for estimating premorbid verbal intelligence in the elderly. J. Clin. Exp. Neuropsychol. 13, 933-949.
32. Gutman, D. A., Holtzheimer, P. E., Behrens, T. E. J., Johansen-Berg, H., and Mayberg, H. S. (2009). A tractography analysis of two deep brain stimulation white matter targets for depression. Biol. Psychiatry 65, 276-282.
33. Hamilton, J. P., Chen, G., Thomason, M. E., Schwartz, M. E., and Gotlib, I. H. (2011). Investigating neural primacy in major depressive disorder: multivariate Granger causality analysis of resting-state fMRI time-series data. Mol. Psychiatry 16, 763-772.
34. Hamilton, M. (1960). A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23, 56-62.
35. Hammen, C. (2003). Interpersonal stress and depression in women. J. Affect. Disord. 74, 49-57.
36. Hassel, S., Almeida, J. R. C., Kerr, N., Nau, S., Ladouceur, C. D., Fissell, K., Kupfer, D. J., and Phillips, M. L. (2008). Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. Bipolar Disord. 10, 916-927.
37. Heller, A. S., Johnstone, T., Shackman, A. J., Light, S. N., Peterson, M. J., Kolden, G. G., Kalin, N. H., and Davidson, R. J. (2009). Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of frontostriatal brain activation. Proc. Natl. Acad. Sci. U.S.A. 106, 22445-22450.
38. Hooley, J. M., Gruber, S. A., Parker, H. A., Guillaumot, J., Rogowska, J., and Yurgelun-Todd, D. A. (2009). Corticolimbic response to personally challenging emotional stimuli after complete recovery from depression. Psychiatry Res. 172, 83-91.
39. Jaracz, J., and Rybakowski, J. (2002). Studies of cerebral blood flow in metabolism in depression using positron emission tomography (PET). Psychiatr. Pol. 36, 617-628.
40. Keedwell, P. A., Drapier, D., Surguladze, S., Giampietro, V., Brammer, M., and Phillips, M. (2010). Subgenual cingulate and visual cortex responses to sad faces predict clinical outcome during antidepressant treatment for depression. J. Affect. Disord. 120, 120-125.
41. Kendler, K. S., Gardner, C. O., and Prescott, C. A. (2002). Toward a comprehensive developmental model for major depression in women. Am. J. Psychiatry 159, 1133-1145.
42. Kito, S., Fujita, K., and Koga, Y. (2008). Changes in regional cerebral blood flow after repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in treatment-resistant depression. J. Neuropsychiatry Clin. Neurosci. 20, 74-80.
43. Korb, A. S., Hunter, A. M., Cook, I. A., and Leuchter, A. F. (2009). Rostral anterior cingulate cortex theta current density and response to anti-depressants and placebo in major depression. Clin. Neurophysiol. 120, 1313-1319.
44. Langenecker, S. A., Kennedy, S. E., Guidotti, L. M., Briceno, E. M., Own, L. S., Hooven, T., Young, E. A., Akil, H., Noll, D. C., and Zubieta, J.-K. (2007). Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder. Biol. Psychiatry 62, 1272-1280.
45. Lawrence, N. S., Williams, A. M., Surguladze, S., Giampietro, V., Brammer, M. J., Andrew, C., Frangou, S., Ecker, C., and Phillips, M. L. (2004). Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar disorder and major depression. Biol. Psychiatry 55, 578-587.
46. Luks, T. L., Simpson, G. V., Dale, C. L., and Hough, M. G. (2007). Preparatory allocation of attention and adjustments in conflict processing. Neuroimage 35, 949-958.
47. Maldjian, J. A., Laurienti, P. J., Kraft, R. A., and Burdette, J. H. (2003). An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19, 1233-1239.
48. Matthews, S. C., Strigo, I. A., Simmons, A. N., Yang, T. T., and Paulus, M. P. (2008). Decreased functional coupling of the amygdala and supragenual cingulate is related to increased depression in unmedicated individuals with current major depressive disorder.J. Affect. Disord. 111, 13-20.
49. Mayberg, H. S. (1999). Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am. J. Psychiatry 156, 675-682.
50. Mayberg, H. S. (2003). Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br. Med. Bull. 65, 193-207.
51. Mayberg, H. S. (2005). Deep brain stimulation for treatment-resistant depression. Neuron 45, 651-660.
52. Mayberg, H. S., Liotti, M., Brannan, S. K., Mcginnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., and Fox, P. T. (1999). Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness. Am. J. Psychiatry 156, 675-682.
53. McGrath, E., Keita, G. P., Strickland, B. R., and Russo, N. F. (2009). Women and Depression: Risk Factors and Treatment Issues: Final Report of the American Psychological Association's National Task Force on Women and Depression. Washington, DC: American Psychological Association.
54. Mechelli, A., Price, C. J., Noppeney, U., and Friston, K. J. (2003). A dynamic causal modeling study on category effects: bottom-up or top-down mediation? J. Cogn. Neurosci. 15, 925-934.
55. Mitterschiffthaler, M. T., Kumari, V., Malhi, G. S., Brown, R. G., Giampietro, V. P., Brammer, M. J., Suckling, J., Poon, L., Simmons, A., Andrew, C., and Sharma, T. (2003). Neural response to pleasant stimuli in anhedonia: an fMRI study. Neuroreport 14, 177-182.
56. Mulert, C., Juckel, G., Brunnmeier, M., Karch, S., Leicht, G., Mergl, R., Moller, H. J., Hegerl, U., and Pogarell, O. (2007). Rostral anterior cingulate cortex activity in the theta band predicts response to antidepressive medication. Clin. EEG Neurosci. 38, 78-81.
57. Ongur, D., Ferry, A. T., and Price, J. L. (2003). Architectonic subdivision of the human orbital and medial prefrontal cortex. J. Comp. Neurol. 460, 425-449.
58. Phillips, M. L., Drevets, W. C., Rauch, S. L., and Lane, R. (2003). Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol. Psychiatry 54, 515-528.
59. Phillips, M. L., Ladouceur, C. D., and Drevets, W. C. (2008a). A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol. Psychiatry 13, 829, 833-857.
60. Phillips, M. L., Ladouceur, C. D., and Drevets, W. C. (2008b). A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol. Psychiatry 13, 833-857.
61. Pizzagalli, D. A. (2011). Frontocingulate dysfunction in depression: toward biomarkers of treatment response. Neuropsychopharmacology 36, 183-206.
62. Price, J. L., and Drevets, W. C. (2010). Neurocircuitry of mood disorders. Neuropsychopharmacology 35, 192-216.
63. Rossion, B., Dricot, L., Devolder, A., Bodart, J.-M., Crommelinck, M., Gelder, B. D., and Zoontjes, R. (2000). Hemispheric asymmetries for whole-based and part-based face processing in the human fusiform gyrus.J. Cogn. Neurosci. 12, 793-802.
64. Sackeim, H. A. (2001). The definition and meaning of treatment-resistant depression.J. Clin. Psychiatry 62(Suppl. 16), 10-17.
65. Saxena, S., Brody, A. L., Ho, M. L., Zohrabi, N., Maidment, K. M., and Baxter, L. R. Jr. (2003). Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am. J. Psychiatry 160, 522-532.
66. Schlösser, R. G. M., Wagner, G., Koch, K., Dahnke, R., Reichenbach, J. R., and Sauer, H. (2008). Frontocingulate effective connectivity in major depression: a study with fMRI and dynamic causal modeling. Neuroimage 43, 645-655.
67. Schuyler, B., Ollinger, J. M., Oakes, T. R., Johnstone, T., and Davidson, R. J. (2010). Dynamic causal modeling applied to fMRI data shows high reliability. Neuroimage 49, 603-611.
68. Sergent, J., and Bindra, D. (1981). Differential hemispheric processing of faces: methodological considerations and reinterpretation. Psychol. Bull. 89, 541-554.
69. Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., and Mintun, M. A. (2001). Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol. Psychiatry 50, 651-658.
70. Sheline, Y. I., Price, J. L., Yan, Z., and Mintun, M. A. (2010). Restingstate functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc. Natl. Acad. Sci. U.S.A. 107, 11020-11025.
71. Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., and Carter, C. S. (2002). Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol. Psychiatry 51, 693-707.
72. Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., and Thase, M. E. (2007). Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features. Biol. Psychiatry 61, 198-209.
73. Smith, D. J., Kyle, S., Forty, L., Cooper, C., Walters, J., Russell, E., Caesar, S., Farmer, A., Mcguffin, P., Jones, I., Jones, L., and Craddock, N. (2008). Differences in depressive symptom profile between males and females. J. Affect. Disord. 108, 279-284.
74. Surguladze, S., Brammer, M. J., Keedwell, P., Giampietro, V., Young, A. W., Travis, M. J., Williams, S. C. R., and Phillips, M. L. (2005). A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biol. Psychiatry 57, 201.
75. Suslow, T., Konrad, C., Kugel, H., Rumstadt, D., Zwitserlood, P., Schöning, S., Ohrmann, P., Bauer, J., Pyka, M., Kersting, A., Arolt, V., Heindel, W., and Dannlowski, U. (2010). Automatic mood-congruent amygdala responses to masked facial expressions in major depression. Biol. Psychiatry 67, 155-160.
76. Sutton, S.K., and Davidson, R.J. (1997). Prefrontal brain asymmetry: a biological substrate of the behavioral approach and inhibition systems. Psychol. Sci. 8, 204-210.
77. Tottenham, N., Tanaka, J. W., Leon, A. C., Mccarry, T., Nurse, M., Hare, T. A., Marcus, D. J., Westerlund, A., Casey, B. J., and Nelson, C. (2009). The NimStim set of facial expressions: judgments from untrained research participants. Psychiatry Res. 168, 242-249.
78. Van Veen, V., and Carter, C. S. (2002). The timing of action-monitoring processes in the anterior cingulate cortex. J. Cogn. Neurosci. 14, 593-602.
79. Versace, A., Almeida, J. R., Hassel, S., Walsh, N. D., Novelli, M., Klein, C. R., Kupfer, D. J., and Phillips, M. L. (2008). Elevated left and reduced right orbitome-dial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch. Gen. Psychiatry 65, 1041-1052.
80. Victor, T. A., Furey, M. L., Fromm, S. J., Ohman, A., and Drevets, W. C. (2010). Relationship between amygdala responses to masked faces and mood state and treatment in major depressive disorder. Arch. Gen. Psychiatry 67, 1128-1138.
81. Wagner, G., Koch, K., Schachtzabel, C., Reichenbach, J. R., Sauer, H., and Schlosser Md, R. G. (2008). Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression. J. Psychiatry Neurosci. 33, 199-208.
82. Wagner, G., Sinsel, E., Sobanski, T., Kohler, S., Marinou, V., Mentzel, H. J., Sauer, H., and Schlosser, R. G. (2006). Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task. Biol. Psychiatry 59, 958-965.
83. Williams, L. M., Das, P., Liddell, B. J., Kemp, A. H., Rennie, C. J., and Gordon, E. (2006). Mode of functional connectivity in amygdala pathways dissociates level of awareness for signals of fear. J. Neurosci. 26, 9264-9271.