Preliminary study on antifertility activity of Enicostemma axillare leaves and Urena lobata root used in Indian traditional folk medicine

Asian Pacific Journal of Tropical Medicine

Volumn 5, Issue 8, 2012, Pages 616-622

  Dhanapal, Ramaiyan ^a   Ratna, J Vijaya ^b   Gupta, Malaya ^c   Sarathchandran, I ^d  

^a ST PETER'S INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

^b ANDHRA UNIVERSITY   (India)

^c JADAVPUR UNIVERSITY   (India)

^d Gokula Krishna College of Pharmacy   (India)

Author keywords

Enicostemma axillare; Folk medicine; Reversible antifertility activity; Spermatogenesis; Steroidogenesis; Urena lobata

Indexed keywords

3BETA HYDROXY DELTA5 STEROID DEHYDROGENASE; ALCOHOL; ASCORBIC ACID; CHOLESTEROL; ENICOSTEMMA AXILLARE EXTRACT; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; MALE CONTRACEPTIVE AGENT; PLANT EXTRACT; UNCLASSIFIED DRUG; URENA LOBATA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CONTRACEPTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG MEGADOSE; ENICOSTEMMA AXILLARE; ENZYME ACTIVITY; EPIDIDYMIS; FEMALE; GENTIANACEAE; LD 50; LOW DRUG DOSE; MALE; MALVACEAE; NONHUMAN; PLANT LEAF; PLANT ROOT; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; SEMINAL VESICLE; SINGLE DRUG DOSE; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTIS WEIGHT; URENA LOBATA; WEIGHT REDUCTION;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; CONTRACEPTIVE AGENTS, MALE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FERTILITY; GENITALIA, MALE; GENTIANACEAE; INDIA; MALE; MALVACEAE; MEDICINE, TRADITIONAL; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; RATS; RATS, WISTAR; SPERM COUNT; SPERM MOTILITY; SPERMATOGENESIS; SPERMATOZOA;

EID: 84864300199     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(12)60127-8     Document Type: Article

References (42)

1. Page ST, Amory JK, Bremner WJ Advances in male contraception. Endocr Rev 2008, 29(4):465-493.
2. Gupta RS, Sharma R A review on medicinal plants exhibiting antifertility activity in males. Nat Prod Rad 2006, 5(5):389-410.
3. D'Cruz SC, Vaithinathan S, Jubendradass R, Mathur PP Effects of plants and plant products on the testis. Asian J Androl 2010, 12:468-479.
4. Ogbuewu IP, Unamba-Oparah IC, Odoemenam VU, Etuk IF, Okoli IC The potentiality of medicinal plants as the source of new contraceptive principles in males. North Am J Med Sci 2011, 3(6):255-262.
5. Khare CP Indian medicinal plants: An illustrated dictionary 2007, 239-240. Springer Science Business Media, LLC, New York. 1st edition.
6. Kirtikar KR, Basu BD Indian medicinal plants 1999, 1655-1656. Mahendra Pal Sing Publication, Dehradun. 2nd edition. S. Bishen (Ed.).
7. Leelaprakash G, Mohan Dass S In vitro anti-inflammatory activity of methanol extract of Enicostemma axillare. Int J Drug Dev & Res 2011, 3(2):162-170.
8. Thirumalai T, Viviyan Therasa S, Elumalai EK, David E Hypolipidemic and antioxidant effect of Enicostemma littorale Blume. Asian Pac J Trop Biomed 2011, 1(5):381-385.
9. Jaishree V, Badami S Antioxidant and hepatoprotective effect of swertiamarin from Enicostemma axillare against D-galactosamine induced acute liver damage in rats. J Ethnopharmacol 2010, 130(1):103-106.
10. Jaishree V, Badami S, Rupesh Kumar M, Tamizhmani T Antinociceptive activity of swertiamarin isolated from Enicostemma axillare. Phytomed 2009, 16(2-3):227-232.
11. Sharada-Deore L, Khadabadi SS, Lalita B, Ghorpade DS In vitro antimicrobial and antioxidant studies on Enicostemma axillare (Lam.) Raynal. Leaves. Nat Prod Rad 2008, 7(5):409-412.
12. Pharmacognosy of Ayurvedic drug 1962, 108-112. Department of Pharmacognosy, University of Kerala.
13. Mazumder UK, Gupta M, Manikandan L, Bhattacharya S Antibacterial activity of Urena lobata root. Fitoterapia 2001, 72(8):927-929.
14. Manandhar NP Plants and people of Nepal 2002, Timber Press, Portland, OR.
15. Ahmad FB, Holdsworth DK Medicinal plants of Sabah East Malaysia, Part I. Pharm Biol 2003, 41:341-346.
16. Pinto MM, Sousa ME, Nascimento MS Xanthone derivatives: New insights in biological activities. Curr Med Chem 2005, 12:2517-2538.
17. Mathappan R, Prasanth VV, Jolly CI, Somanath M Comparative study on the antibacterial activity of the methanolic extract of Urena lobata root and a standard marketed herbal formulation. J Pharm Res 2010, 3(5):953-955.
18. Onoagbe IO, Negbenebor EO, Ogbeide VO, Dawha IH, Attah V, Lau HU, et al. A study of the anti-diabetic effects of Urena lobata and Sphenostylis stenocarpa in streptozotocin-induced diabetic rats. Eur J Sci Res 2010, 43(1):6-14.
19. Mathappan R, Prasanth VV, Parthasarathy G Immunomodulatory activity of the methanolic extract of Urena lobata Linn. Internet J Pharmacol 2009, 7.
20. Keshab G A furocoumarin, Imperatorin isolated from Urena lobata L (Malvaceae). Int J Mol Sci 2004, M382:1-2.
21. Committee for the Purpose of Control and Supervision of Experiments on Animals. Guidelines for laboratory animal facilities. Chennai: 3.
22. Organization for Economic Co-operation and Development. Guidance document on acute oral toxicity, guidelines for the testing of chemicals. Revised Document. Annexure-6. 2000.
23. Akbarsha MA, Kadalmani B, Girija R, Faridha A, Shahul Hamid K Spermatotoxic effect of carbendazim. J Exp Biol 2001, 39:921-924.
24. World Health Organization Laboratory manual for the examination and processing of human semen 2010, World Health Organization, Geneva. 5th edition.
25. Raphael SS Cytologic diagnosis. Lynch's medical laboratory technology 1976, 1454-1485. WB Saunders Company, Toronto. S.S. Raphael (Ed.).
26. Gopalakrishnan K Estimating sperm concentration by cytometry. Laboratory manual for human semen analysis 1994, 8-9. ICMR and WHO Collaborating Centre for Research in Human Reproduction, Bombay. K. Gopalakrishnan, I. Hinduja, R.H. Mehta (Eds.).
27. Sperry WM, Webb M A revision of Schoenheimer-Sperry method for cholesterol determination. J Biol Chem 1950, 87:97-106.
28. Omaye ST, Turnbull JD, Souberlich HE Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods in enzymology 1979, vol. 62:3-47. Academic Press, New York. D.B. McCormick, L.D. Wright (Eds.).
29. Rabin BL, Leipsner G, Deane HW A rapid sensitive assay procedure for adrenal steroid 3 OH dehydrogenase activities. Endocrinol 1961, 69:619-625.
30. Lohr GW, Waller HD Determination of glucose-6-phosphate dehydrogenase. Methods of enzymatic analysis 1965, 744-751. Academic Press, New York. H.U. Bergmeyer (Ed.).
31. Lowry OH, Rosenbrough NJ, Farm AL, Randall RJ Protein measurement with folin phenol reagent. J Biol Chem 1951, 193:265-275.
32. Padashetty SA, Mishra SH Effect of terpenoidal fraction of Echinops echinatus roots on reproductive parameters of male rats. J Nat Med 2007, 61(4):452-457.
33. Singh A, Singh SK Reversible antifertility effect of aqueous leaf extract of Allamanda cathartica L. in male laboratory mice. Andrologia 2008, 40(6):337-345.
34. Bairy L, Paul V, Rao Y Reproductive toxicity of sodium valproate in male rats. Indian J Pharmacol 2010, 42(2):90-94.
35. Gupta RS, Sharma A, Kachhawa JBS Evaluations of reversible contraceptive activities of Annona squamosa (Linn) stem bark methanol extract in male rats. Plant Prod Res J 2010, 14:28-31.
36. Sharma N, Jacob D Antifertility investigation and toxicological screening of the petroleum ether extract of the leaves of Mentha arvensis L. in male albino mice. J Ethnopharmacol 2001, 75:5-12.
37. Pankajakshy A, Madambath I Spermatotoxic effects of Cananga odorata (Lam): a comparison with gossypol. Fertil Steril 2009, 91(5):2243-2246.
38. Rajnish G, Kachhawa Jai BS, Gupta RS, Kumar SA, Sharma MC, Dobhal MP Phytochemical evaluation and antispermatogenic activity of Thevetia peruviana methanol extract in male albino rats. Hum Fertil 2011, 14(1):53-59.
39. Hammami1 I, Nahdi1 A, Mauduit C, Benahmed M, Amri M, Amar AB, et al. The inhibitory effects on adult male reproductive functions of crude garlic (Allium sativum) feeding. Asian J Androl 2008, 10(4):593-601.
40. Sarathchandiran I, Manavalan R, Akbarsha MA, Kadalmani B, Karar PK Effects of ethanolic extract of Capparis (Roth) on testicular steroidogenesis in rats. J Biol Sci 2007, 7(3):582-584.
41. Maiti S, Gupta M, Mazumder UK Toxicological potential of mycotoxin MT81 and its benzoylated derivative on testicular spermatogenesis and steroidogenesis in mature male Wistar albino rats. Toxicol Mech Method 2011, 21(5):426-433.
42. Anuja MNMK, Nithya RMSA, Rajamanickam C, Madambath I Spermatotoxicity of a protein isolated from the root of Achyranthes aspera: a comparative with gossypol. Contracept 2010, 82(4):385-390.