Protective effect of gliclazide on diabetic peripheral neuropathy through Drp-1 mediated-oxidative stress and apoptosis

Neuroscience Letters

Volumn 523, Issue 1, 2012, Pages 45-49

  Wu, Yuan bo ^a   Shi, Li li ^a   Wu, Yuan jie ^b   Xu, Wen hua ^a   Wang, Li ^a   Ren, Ming shan ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Anhui College of Traditional Chinese Medicine   (China)

Author keywords

Diabetic peripheral neuropathy; Dynamin related protein 1; Gliclazide; Nerve conduction velocity

Indexed keywords

CASPASE 3; DYNAMIN; DYNAMIN RELATED PROTEIN 1; GLICLAZIDE; MALONALDEHYDE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEMYELINATION; DIABETIC NEUROPATHY; DRUG EFFECT; ENZYME ACTIVITY; MALE; NERVE CONDUCTION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RAT; SCIATIC NERVE; STATISTICAL SIGNIFICANCE; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; APOPTOSIS; DIABETIC NEUROPATHIES; GLICLAZIDE; HYPOGLYCEMIC AGENTS; MALE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; TREATMENT OUTCOME;

EID: 84864297505     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.06.038     Document Type: Article

References (25)

1. Vincent A.M., Brownlee M., Russell J.W. Oxidative stress and programmed cell death in diabetic neuropathy. Annals of the New York Academy of Sciences 2002, 959:368-383.
2. Sima A.A. New insights into the metabolic and molecular basis for diabetic neuropathy. Cellular and Molecular Life Sciences 2003, 60:2445-2464.
3. Figueroa-Romero C., Sadidi M., Feldman E.L. Mechanisms of disease: the oxidative stress theory of diabetic neuropathy. Reviews in Endocrine and Metabolic Disorders 2008, 9:301-314.
4. Vincent A.M., Edwards J.L., McLean L.L., Hong Y., Cerri F., Lopez I., Quattrini A., Feldman E.L. Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy. Acta Neuropathologica 2010, 120:477-489.
5. Reddy P.H., Reddy T.P., Manczak M., Calkins M.J., Shirendeb U., Mao P. Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases. Brain Research Reviews 2011, 67:103-118.
6. Chen H., Chan D.C. Mitochondrial dynamics - fusion, fission, movement, and mitophagy - in neurodegenerative diseases. Human Molecular Genetics 2009, 18:R169-R176.
7. Strack S., Cribbs J.T. Allosteric modulation of Drp1 assembly and mitochondrial fission by the variable domain. Journal of Biological Chemistry 2012, 287:10990-11001.
8. Peng L., Men X., Zhang W., Wang H., Xu S., Xu M., Xu Y., Yang W., Lou J. Dynamin-related protein 1 is implicated in endoplasmic reticulum stress-induced pancreatic beta-cell apoptosis. International Journal of Molecular Medicine 2011, 28:161-169.
9. Qiang X., Satoh J., Sagara M., Fukuzawa M., Masuda T., Miyaguchi S., Takahashi K., Toyota T. Gliclazide inhibits diabetic neuropathy irrespective of blood glucose levels in streptozotocin-induced diabetic rats. Metabolism 1998, 47:977-981.
10. Fukuzawa M., Satoh J., Qiang X., Miyaguchi S., Sakata Y., Nakazawa T., Ikehata F., Ohta S., Toyota T. Inhibition of tumor necrosis factor-alpha with anti-diabetic agents. Diabetes Research and Clinical Practice 1999, 43:147-154.
11. Scott N.A., Jennings P.E., Brown J., Belch J.J. Gliclazide: a general free radical scavenger. European Journal of Pharmacology 1991, 208:175-177.
12. Del Guerra S., Grupillo M., Masini M., Lupi R., Bugliani M., Torri S., Boggi U., Del Chiaro M., Vistoli F., Mosca F., Del Prato S., Marchetti P. Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose. Diabetes: Metabolism Research and Reviews 2007, 23:234-238.
13. Corgnali M., Piconi L., Ihnat M., Ceriello A. Evaluation of gliclazide ability to attenuate the hyperglycaemic 'memory' induced by high glucose in isolated human endothelial cells. Diabetes: Metabolism Research and Reviews 2008, 24:301-309.
14. Schmeichel A.M., Schmelzer J.D., Low P.A. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes 2003, 52:165-171.
15. Leinninger G.M., Backus C., Sastry A.M., Yi Y.B., Wang C.W., Feldman E.L. Mitochondria in DRG neurons undergo hyperglycemic mediated injury through Bim, Bax and the fission protein Drp1. Neurobiology of Disease 2006, 23:11-22.
16. Lu M.L., Dai M.C., Zhao Y., Liu Z.M., Zheng J.J. Roles of Drp-1 in diabetic rat sciatic nerve and effects of resveratrol intervention. Labeled Immunoassays and Clinical Medicine 2010, 17:250-255.
17. Zherebitskaya E., Akude E., Smith D.R., Fernyhough P. Development of selective axonopathy in adult sensory neurons isolated from diabetic rats: role of glucose-induced oxidative stress. Diabetes 2009, 58:1356-1364.
18. Vincent A.M., L.L.McLean, Backus C., Feldman E.L. Short-term hyperglycemia produces oxidative damage and apoptosis in neurons. FASEB Journal 2005, 19:638-640.
19. Edwards J.L., Quattrini A., Lentz S.I., Figueroa-Romero C., Cerri F., Backus C., Hong Y., Feldman E.L. Diabetes regulates mitochondrial biogenesis and fission in mouse neurons. Diabetologia 2010, 53:160-169.
20. Yu T., Robotham J.L., Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:2653-2658.
21. Russell J.W., Golovoy D., Vincent A.M., Mahendru P., Olzmann J.A., Mentzer A., Feldman E.L. High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB Journal 2002, 16:1738-1748.
22. Jourdain A., Martinou J.C. Mitochondrial outer-membrane permeabilization and remodelling in apoptosis. International Journal of Biochemistry and Cell Biology 2009, 41:1884-1889.
23. Wu S., Zhou F., Zhang Z., Xing D. Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. Journal of Cellular Physiology 2011, 226:530-541.
24. Shroff E.H., Snyder C.M., Budinger G.R., Jain M., Chew T.L., Khuon S., Perlman H., Chandel N.S. BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK. PLoS One 2009, 4:e5646.
25. Jagasia R., Grote P., Westermann B., Conradt B. DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans. Nature 2005, 433:754-760.