Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl 4-induced hepatocellular carcinoma in Wistar rats

Asian Pacific Journal of Tropical Medicine

Volumn 5, Issue 8, 2012, Pages 623-629

  Hussain, Talib ^a,b   Siddiqui, Hefazat H ^a   Fareed, Sheeba ^a   Vijayakumar, M ^b   Rao, Chandana V ^b  

^a INTEGRAL UNIVERSITY   (India)

^b CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

Author keywords

feto protein; Alkaline phosphatase; Fumaria indica; Hepatocellular carcinoma; N nitrosodiethylamine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; ANTINEOPLASTIC AGENT; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CARCINOEMBRYONIC ANTIGEN; DIETHYLNITROSAMINE; FUMARIA INDICA EXTRACT; GAMMA GLUTAMYLTRANSFERASE; PLANT EXTRACT; SILYMARIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFECT; FEMALE; FUMARIA; FUMARIA INDICA; HISTOPATHOLOGY; LIVER CELL CARCINOMA; LIVER NODULE; LIVER WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BODY WEIGHT; CARBON TETRACHLORIDE; CARCINOMA, HEPATOCELLULAR; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FUMARIA; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84864296675     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1995-7645(12)60128-X     Document Type: Article

References (42)

1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127:2893-2917.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D Global cancer statistics. CA: Cancer J Clin 2011, 61:69-90.
3. Paraskevi A, Ronald A Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006, 6:1-14.
4. Singh BN, Singh BR, Sarma BK, Singh HB Potential chemoprevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by polyphenolics from Acacia nilotica bark. Chem Biol Interact 2009, 181:20-28.
5. Sivaramakrishnan V, Shilpa PNM, Kumar VRP, Devaraj SN Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol-Morin. Chem Biol Interact 2008, 171:79-88.
6. Khan MS, Halagowder D, Devaraj SN Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats. Food Chem Toxicol 2011, 49:173-178.
7. Ramakrishnan G, Raghavendran HRB, Vinodhkumar R, Devaki T Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact 2006, 161:104-114.
8. Feo F, Pascale RM, Simile MM, De Miglio MR, Calvisi DM, Calvisi MRD Genetic alterations in liver carcinogenesis: implications for new preventive and therapeutic strategies. Crit Rev Oncol 2000, 11:19-62.
9. Sreepriya M, Bali G Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in Wistar rats. Fitoterapia 2005, 76:549-555.
10. Agarwal BB, Shishodia S Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006, 71:1397-1421.
11. Ravindranath MH, Ramasamy V, Moon S, Ruiz C, Muthugounder S Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG). E-CAM 2009, 6:523-530.
12. Chopr RN, Nayar SL, Chopra SN Glossory of Indian medicinal plants 1985, 122. NISCAIR, New Delhi.
13. Khattak SG, Gilani SN, Ikram M Antipyretic studies on some indigenous Pakistani medicinal plants. J Ethnopharmacol 1985, 14:45-51.
14. Rao ChV, Verma AR, Gupta PK, Vijayakumar M Anti-inflammatory and anti-nociceptive activities of Fumaria indica whole plant extract in experimental animals. Acta Pharm 2007, 57:491-498.
15. Gilani AH, Bashir S, Janbaz KH, Khan A Phormacological basis for the use of Fumaria indica in constipation and diarrhea. J Ethnopharmacol 2005, 96:585-589.
16. Gilani AH, Janbaz KH, Akhtar MS Selective protective effect of the extract from Fumaria perviflora on paracetamol-induced hepatotoxicity. Gen Pharmacol 1996, 27:979-983.
17. Rao KS, Mishra SH Anti hepatotoxic activity of monomethyl fumarate isolated from Fumaria indica. J Ethnopharmacol 1998, 60:207-213.
18. Nimbkar SR, Juvekar AR, Jogalekar SN Hepatoprotective activity of Fumaria indica in hepatotoxicity induced by anti-tubercular drugs treatment. Ind Drugs 2000, 37:537-542.
19. Rathi A, Srivastava AK, Shirwaikar A, Rawat AKS, Mehrotra S Hepatoprotective potential of Fumaria indica Pugsley whole plant extracts, fractions and an isolated alkaloid protopine. Phytomed 2008, 15:470-477.
20. Pandey VB, Gupta BD, Bhattacharya SK, Lal R, Das PK Chemistry and pharmacology of the major alkaloid of Fumaria indica. Curr Sci 1971, 40:455-457.
21. Rahman AU, Bhatti MK, Choudhary MI, Ahmad SK Alkaloidal constituent of Fumaria indica. Phytochem 1995, 40:593-596.
22. Sousek J, Guedon D, Adam T, Bochorakova H, Taborska E, Valka I, et al. Alkaloids and organic acids content of eight Fumaria species. Phytochem Ana 1999, 10:6-11.
23. Organisation for Economic Co-operation and Development Test no. 423: Acute oral toxicity-acute toxic class method 2001, Organisation for Economic Co-operation and Development, Paris.
24. Sundaresan S, Subramanian P Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine. Mol Cell Biochem 2008, 310:209-214.
25. Reitman S, Frankel S A colorimetric method for the determination of serum glutamate oxaloacetate transaminase. Am J Clin Pathol 1957, 28:53-56.
26. King J The hydrolases-acid and alkaline phosphatases. Practical clinical enzymology 1965, 191-208. Nostrand Company Limited, London.
27. Szasz G Reaction rate method for gamma glutamyl transferase activity in serum. Clin Chem 1976, 22:2051-2055.
28. Dangerfield WG, Finlayson R Estimation of bilirubin in serum. J Clin Pathol 1953, 6:173.
29. Sell S, Beckar FF Alpha feto protein. Natl Cancer Inst 1978, 60:19-26.
30. Macnab GM, Urbanowicz JM, Kew MC Carcinoembryonic antigen in hepatocellular cancer. Br J Cancer 1978, 38:51-54.
31. Verna L, Whysner J, Williams GM N-nitrodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther 1996, 71:57-81.
32. Nirmala M, Girija K, Lakshman K, Divya T Hepatoprotective activity of Musa paradisiaca on experimental animal models. Asian Pac J Trop Biomed 2011, 2(1):11-15.
33. Kiran PM, Raju AV, Rao BG Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. Asian Pac J Trop Biomed 2011, 2(5):352-356.
34. Machana S, Weerapreeyakul N, Barusrux S Anticancer effect of the extracts from Polyalthia evecta against human hepatoma cell line (HepG2). Asian Pac J Trop Biomed 2011, 2(5):368-374.
35. Singh K, Singh N, Chandy A, Manigauha A In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals. Asian Pac J Trop Biomed 2011, 2(5):385-388.
36. Machana S, Weerapreeyakul N, Barusrux S, Thumanu K, Tanthanuch W Synergistic anticancer effect of the extracts from Polyalthia evecta caused apoptosis in human hepatoma (HepG2) cells. Asian Pac J Trop Biomed 2011, 2(8):589-596.
37. 4 induced hepatotoxicity in male albino rats. Asian Pac J Trop Dis 2011, 1(4):304-307.
38. Rao GMM, Rao ChV, Pushpangadan P, Annie S Hepatoprotective effects of rubiadin, a major constituent of Rubia cordifolia Linn. J Ethnopharmacol 2006, 103:484-490.
39. Wolf, Harrelson CR, Nastainczyk WG, Philpot WM, Kalyanaraman RMB, Mason RP Metabolism of carbon tetrachloride in hepatic microsomes and reconstituted monooxygenase systems and its relationship to lipid peroxidation. Mol Pharmacol 1980, 18:553-558.
40. Dakshayani KB, Subramanian Manivasagam PT, Essa MM, Manoharan S Melatonin modulates the oxidant-antioxidant imbalance during N-nitrosodiethylamine induced hepatocarcinogenesis in rats. J Pharm Pharmaceut Sci 2005, 8:316-321.
41. Jeena KJ, Joy KL, Kuttan R Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett 1999, 136:11-16.
42. Maeda M, Tozuka S, Kanayama M, Uchida T Hepatocellular carcinoma producing carcinoembryonic antigen. Dig Dis Sci 1988, 33:1629-1631.