In vivo antioxidant and hepatoprotective activity of methanolic extracts of Daucus carota seeds in experimental animals

Asian Pacific Journal of Tropical Biomedicine

Volumn 2, Issue 5, 2012, Pages 385-388

  Singh, Kamlesh ^a   Singh, Nisha ^b   Chandy, Anish ^c   Manigauha, Ashish ^d  

^a Rawatpura Sarkar Institute of Pharmacy   (India)

^b Barpali Institute of Pharmacy   (India)

^c Chouksey Engineering College   (India)

^d DR H S GOUR UNIVERSITY   (India)

Author keywords

Antioxidant; Biochemical parameters; Daucus carota seeds extract; Hepatoprotection; Silymarin; Thioacetamide

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; DAUCUS CAROTA EXTRACT; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; LIPID; LIVER ENZYME; METHANOL; PLANT EXTRACT; SILYMARIN; SUPEROXIDE DISMUTASE; THIOACETAMIDE; UNCLASSIFIED DRUG; ANTIOXIDANT; GLUTATHIONE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CARROT; CONTROLLED STUDY; EXPERIMENTAL ANIMAL; IN VIVO STUDY; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; PLANT SEED; PRIORITY JOURNAL; RAT; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; LIVER; PATHOLOGY; PHYTOTHERAPY; PROCEDURES;

ANIMALIA; DAUCUS CAROTA; RATTUS;

ALANINE TRANSAMINASE; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; DAUCUS CAROTA; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; GLUTATHIONE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDATION; LIVER; METHANOL; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; SEEDS; SUPEROXIDE DISMUTASE; THIOACETAMIDE;

EID: 84858190495     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2221-1691(12)60061-6     Document Type: Article

References (27)

1. Nagler R, Reznick A, Shafir Y, Shehadeh N. Free radical related effects and antioxidants in saliva and serum of adolescents with Type 1 diabetes metllitus. Arch Oral Biol 2006; 40: 156.
2. Vertuani S, Angusti A, Manfredini S. The antioxidant and proantioxidants network: An overview. Curr Pharm Des 2004; 10: 1677-1694.
3. Devasagayam TPA, Tilak JC, Boloor KK. Review: free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 2004; 52: 794-804.
4. Vasudevan M, Gunnam KK, Parle M. Antinociceptive and anti-inflammatory properties of Daucus carota seeds extract. J Health Sci 2006; 52: 598-606.
5. Fu HW, Zhang L, Yi T, Feng YL, Tian JK. Two new guaiane-type sesquiterpenoids from the fruits of Daucus carota L. Fitoterapia 2010; 81: 443-446.
6. Rana Z, Malcolm R, Christine L, Le Maitre. Bioactive chemicals from carrot (Daucus carota) juice extracts for the treatment of leukemia. J Med Food 2011; 14: 1-10.
7. Stange C, Fuentes P, Handford M, Pizarro L. Daucus carota as a noval model to evaluate the effect of light on carotenogenic geneexpression. Boil Res 2008; 41: 289-301.
8. Gilani AH, Shaheen E, Saeed SA, Bibi S, Irfanullah, Sadiq M, et al. Hypotensive action of coumarin glycosides from Daucus carota. Phytomed 2000; 7: 423-426.
9. Arjuman A, Nair V, Gopalakrishna HN, Nandini M. Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation)and its individual constituents in reversing haloperodal-inducedcatalepay in mice. Indian J Pharmacol 2007; 39(3): 151-154.
10. Manigauha A, Patel S, Ali H, Chandy A, Uma Maheshwari M. Study the effect of phytochemical constituents of Piper betel leaves extracts on liver disorders by in vivo model. J Pharm Res 2009: 2: 353-356.
11. Manigaunha A, Ganesh N, Kharya MD. Hepatoprotection by Kaempferia galanga against carbon tetrachloride induced liver damage in rats. Indian Drugs 2010: 47: 55-60.
12. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, et al. Selenium: Biochemical role as a component of glutathione peroxidase. Sci 1973; 179: 588-590.
13. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferase, thefirst enzymatic step in mercapturicacid formation. J Biol Chem 1974; 249: 7130-7139.
14. Ellman GL. Tissue sulphydryl groups. Arch Biochem Biophys 1959; 82: 70-77.
15. Kakkar P, Das B, Viswanathan PN. A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 1984;21(2): 130-132.
16. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972: 47: 389-394.
17. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presenceof xylenol orange for detection of lipid hydroperoxide in lowdensity lipoprotein. Anal Biochem 1992; 202: 384-389.
18. Mondal A, Maity TK, Pal D, Sannigrahi S, Singh J. Isolation and in vivo hepatoprotective activity of Melothria heterophylla (Lour.) Cogn. against chemically induced liver injuries in rats. Asian Pac J Trop Med 2011; 4(8): 619-623.
19. 4 induced hepatotoxicity. Asian Pac J Trop Med 2011; 4(6): 462-465.
20. Eesha BR, Amberkar VM, Kumari KM, Sarath B, Vijay M, Lalit M, et al. Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats. Asian Pac J Trop Med 2011; 4(6): 466-469.
21. 4 induced acute liver toxicity in experimental animals. An Pac J Trop Med 2011; 4(12): 964-968.
22. 4 induced hepatotoxicity in male albino rats Asian Pac J Trop Med 2011; 4: 304-307.
23. Nwaehujor CO, Udeh NE. Screening of ethyl acetate extract of Bridelia micrantha for hepatoprotective and anti-oxidant activities on Wistar rats. Asian Pac J Trop Med 2011; 4(10): 796-798.
24. Nnodim J, Anyadoh SO, Nwosunjoku EC. The antioxidant status and lipid peroxidation product of newly diagnosed and 6 weeks follow-up patients with pulmonary tuberculosis in Owerri, Imo state, Nigeria. Asian Pac J Trop Dis 2011; 1(4): 292-294.
25. 4 induced hepatotoxicity in male albino rats. Asian Pac J Trop Dis 2011; 1(4): 304-307.
26. OL Erukainure, JA Ajiboye, RO Adejobi, OY Okafor, Sunday. Protective effect of pineapple (Ananas cosmosus) peel extract onalcohol-induced oxidative stress in brain tissues of male albino rats. Asian Pac J Trop Dis 2011; 1(1): 5-9.
27. Fatih Aydin A, Kusku-Kiraz Z, Dogru-Abbasoglu S, Gulluoglu M, Uysal M, Kocak-Toker N. Effect of carnosine againstthioacetamide induced liver cirrhosis in rat. Pept 2010; 31: 67-71.