Restorative effect of Eclipta alba in CCl 4 induced hepatotoxicity in male albino rats

Asian Pacific Journal of Tropical Disease

Volumn 1, Issue 4, 2011, Pages 304-307

  Thirumalai, T ^a   David, E ^a,b   Therasa, Viviyan ^a   Elumalai, E K ^a  

^a VOORHEES COLLEGE   (India)

^b THIRUVALLUVAR UNIVERSITY   (India)

Author keywords

Antioxidant enzyme; Carbon tetrachloride; Eclipta alba; Hepatic injury; Hepatotoxicity; Hydrogen peroxide; Oxidative stress; Restorative effect

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CATALASE; ECLIPTA ALBA EXTRACT; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROPEROXIDE; OLIVE OIL; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFICACY; ENZYME ACTIVITY; LIVER INJURY; LIVER PARENCHYMA; LIVER PROTECTION; MALE; NONHUMAN; OPTIMAL DRUG DOSE; OXIDATIVE STRESS; PLANT LEAF; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT; TOXIC HEPATITIS; TREATMENT DURATION;

EID: 84856840684     PISSN: 22221808     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2222-1808(11)60072-8     Document Type: Article

References (33)

1. Patel JA, Shah US Hepatoprotective activity of Piper longum traditional milk extract on carbon tetrachloride induced liver toxicity in Wistar rats. Bol Latinoam Caribe Plant Med Aromat 2009, 8(2):121-129.
2. Halliwell B, Gutteridge JMC Free radicals in biology and medicine 2007, Oxford University Press, Nueva York.
3. Shen X, Tang Y, Yang R, Yu L, Fang T, Duan JA The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities. J Ethnopharmacol 2009, 122(3):555-560.
4. Shaarawy MS, Tohamy AA, Elgendy MS, Abd Elmageed YZ, Bahnasy A, Mohamed SM, et al. Protective effects of garlic and silymarin on NDEA-induced rats hepatotoxicity. Int J Biol Sci 2009, 5(6):549-557.
5. Pradeep K, Mohan CV, Gobianand K, Karthikeyan S Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol 2007, 560(2-3):110-116.
6. Amin A, Mahmoud-Ghoneim D Zizyphusspina-christi protects against carbon tetrachloride induced liver fibrosis in rats. Food Chem Toxicol 2009, 47(8):2111-2119.
7. Halliwell B, Gutteridge J Oxygen toxicity, oxygen radicals, transition metals and disease. J Biol Chem 1984, 219(1):1-14.
8. Ananthi J, Prakasam A, Pugalendi KV Antihyperglycemic activity of Eclipta alba leaf on alloxan induced diabetic rats. Yale J Biol Med 2003, 76(3):97-102.
9. Saggoo MIS, Kaur R, Gupta RC Comparison of antibacterial activity of three morphotypes of medicinal herb Eclipta alba (L.) Hassk. Der Pharm Lett 2010, 2(6):200-207.
10. Arunachalam G, Subramanian N, Pazhani GP, Ravichandran V Anti-inflammatory activity of methanolic extract of Eclipta prostrata L. (Astearaceae). Afr J Pharm Pharmacol 2009, 3:97-100.
11. Bhringraj [Online] [Accessed on 20 Dec, 2010]. http://www.allayurveda.com/herb_month_february2009.asp.
12. Eclipta alba (Han lian cao). [Online] [Accessed on 25 Mar, 2011]. http://www.naturopathydigest.com/nutrition_herbs/herbs/eclipta.php.2009.
13. Reitman S, Frankel S A colorimetric method for the determination serum oxaloacetic and glutamic pyruvate transaminase. Am J Clin Pathol 1957, 28:56-63.
14. King EJ, Amstrong AR Determination of serum and bile phosphate activity. Can J Med Assoc 1934, 3:376.
15. Nichans WG, Samuelson B Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 1986, 6:126-130.
16. Jiang ZY, Hunt JV, Wolff SP Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem 1992, 202:384-387.
17. Kakkar P, Das B, Viswanathan PN A modified spectrophotometric assay of SOD. Indian J Biochem Biophys 1984, 21:130-132.
18. Sinha KA Colorimetric assay of catalase. Anal Biochem 1972, 47:389-394.
19. Rotruck JT, Pope AL, Ganther HE, Swason AB Selenium: biochemical role as a component of glutathione peroxidase. Science 1973, 179:588-590.
20. Habig WH, Pabst MJ, Jakpoly WB Glutathione transferase: a first enzymatic step in mercapturic acid and formation. J Biol Chem 1974, 249:7130-7139.
21. Giboney PT Mildly elevated liver transaminase levels in the asymptomatic patient. Am Fam Physician 2005, 71(6):1105-1110.
22. 4 induced liver toxicity in albino mice. Asian Pac J Trop Med 2010, 3(10):757-840.
23. Reddy J, Gnanasekaran D, Vijay D, Ranganathan TV Studies on hepatoprotective activity of traditional ayurvedic formulation 'Vidakana Choornam' against carbon tetrachloride induced hepatotoxicity in albino rat. Int J Pharm Anal 2010, 2(2):5-16.
24. Chen WY, Chen CJ, Liao JW, Mao FC Chromium attenuates hepatic damage in a rat model of chronic cholestasis. Life Sci 2009, 84(17-18):606-614.
25. Kanchana N, Sadiq AM Hepatoprotective effect of Plumbago zeylanica on paracetamol induced liver toxicity in rats. Int J Pharm Pharm Sci 2011, 3(1):151-154.
26. Okafor OY, Erukainure OL, Ajiboye JA, Adejobi RO, Owolabi FO, Kosoko SB Modulatory effect of pineapple peel extract on lipid peroxidation, catalase activity and hepatic biomarker levels in blood plasma of alcoholinduced oxidative stressed rats. Asian Pac J Trop Biomed 2011, 1(1):12-14.
27. Ganie SA, Haq E, Masood A, Hamid A, Zargar MA Antioxidant and protective effect of ethyl acetate extract of Podophyllum hexandrum rhizome on carbon tetrachloride induced rat liver injury. Evid Based Complement Alternat Med 2011, 2011:1-12.
28. 4 induced experimental mice. J Biol Sci 2009, 17:27-34.
29. Popovic M, Hudomal J, Kaurinovic B, Rasic J, Trivic S Effects of various drugs on alcohol-induced oxidative stress in the liver. Molecules 2008, 13:2249-2259.
30. Bharrhan S, Chopra K, Praveen R Vitamin E supplementation modulates endotoxin-induced liver damage in a rat model. Am J Biomed Sci 2010, 2(1):51-62.
31. Baravalia Y, Vaghasiya Y, Chanda S Hepatoprotective effect of Woodfordia fruticosa Kurz flowers on diclofenac sodium induced liver toxicity in rats. Asian Pac J Trop Med 2011, 4(5):342-346.
32. Desai S, Gite M, Ahmad A, More Y, Gavitre B, Gawali V Hepatoprotective and antioxidant activity evaluation of PHF08 on carbon tetrachloride induced hepatotoxicity. Der Pharm Lett 2010, 2(1):475-481.
33. Rathi MA, Thirumoorthi L, Sunitha M, Meenakshi P, Gurukumar D, Gopalakrishnan VK Hepatoprotective activity of Spermacoce hispida Linn. extract against nitrobenzene induced hepatotoxicity in rats. J Herb Med Toxicol 2010, 4(2):201-205.