Neurolathyrism: Two Ethiopian case reports and review of the literature

Journal of Neurology

Volumn 259, Issue 7, 2012, Pages 1263-1268

  Woldeamanuel, Yohannes W ^a,b   Hassan, Anhar ^c   Zenebe, Guta ^a  

^a ADDIS ABABA UNIVERSITY   (Ethiopia)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Ethiopia; Grasspea; Lathyrus sativus; Neurolathyrism; Spastic paraparesis; Spastic quadraparesis

Indexed keywords

CLONAZEPAM; SPASMOLYTIC AGENT;

ADULT; AGRICULTURAL WORKER; CASE REPORT; FOOD INTAKE; HUMAN; LATHYRISM; LATHYRUS SATIVUS; MALE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; SPASTIC PARESIS;

DIAGNOSIS, DIFFERENTIAL; ETHIOPIA; HUMANS; LATHYRISM; MALE; YOUNG ADULT;

EID: 84864289184     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-011-6306-4     Document Type: Review

References (52)

1. Manmohan S, Gurbachan S (1952) Lathyrism: a neurological and economic problem in India. J Nerv Ment Dis 116:923-932
2. Singhal GD, Singh LM, Singh KP (1972) Diagnostic considerations in ancient Indian surgery. Singhal, Allahabad, pp 77-78
3. Littré É (1846) Oeuvres complètes d'Hippocrate. Baillière, Paris, Vol 5; Book 2; Sect 4. p 126
4. Hendley AG (1903) Lathyrism. Br Med J 2:707-709
5. Sleeman WH (1844) Rambles and recollections of an Indian official. Hatchard and Sons, London
6. Haimanot RT, Kidane Y, Wuhib E et al (1990) Lathyrism in rural northwestern Ethiopia: a highly prevalent neurotoxic disorder. Int J Epidemiol 19:664-672 (Pubitemid 20331815)
7. Cheeke PR (1989) Toxicants of plant origin: proteins and amino acids. CRC-Press, Boca Raton, p 170
8. Goya DF (1863) Los desastres de la Guerra. Plate 51, Madrid
9. Coni N (2002) A historical survey of medicine in Spain during the Spanish Civil War. J R Soc Med 95(3):147-150 (Pubitemid 34242353)
10. Kessler A (1947) Lathyrsmus. Montasschr Psychiatr Neurol 113:345-376
11. Moneim AM, Van Dorrestein B, Baum M et al (2001) Role of ICARDA in improving the nutritional quality and yield potential of grasspea (Lathyrus sativus L.), for subsistence farmers in dry areas. Lathyrus Lathyrism Newsl 2(2):55-58
12. Lambein F, Haque A (1993) Lathyrus sativus and human Lathyrism, Progress and prospects. In: 2nd International Colloquium on Lathyrism in Bangladesh, Dhaka, pp l-53
13. Haimanot RT, Abegaz B, Wuhib E, Kassina A, Kidane Y, Kebede N, Alemu T, Spencer P (1993) Pattern of Lathyrus sativus (grass pea) consumption and beta-N-oxalyl-a-b-diaminoproprionic acid (b-ODAP) content of food samples in the lathyrism endemic region of northwest Ethiopia. Nutr Res 13(10):1113-1126 (Pubitemid 23283764)
14. Rao SLN, Adiga PR, Sharma PS (1964) The isolation & characterization of beta-N-alpha, beta-diaminopropionic acid: a neurotoxin from the seeds of Lathyrus sativus. Biochemistry 3:432
15. Narayan SB, Bhatt DP, Bhatt PN, Mehta AR (1989) Detection of beta oxalyl diamino propionic acid in callus cultures of Lathyrus-Sativus. Curr Sci (Bangalore) 58:112-119
16. Lambien F, Haque R, Khan JK, Kebede N, Kuo YH (1994) From soil to brain: zinc deficiency increases the neurotoxicity of Lathyrus sativus and may affect the susceptibility for the motor neurone disease NL. Toxicon 32:461-466 (Pubitemid 24160412)
17. Ross SM, Roy DN, Spencer PS (1989) b-N-Oxalylamino-L-alanine action of glutamate receptors. J Neurochem 53:710-715
18. Bridges RJ, Stevens DR, Kahle JS, Nunn PB, Kadri M, Cotman CW (1989) Structure-function studies on N-oxalyl-diaminodicarboxylic acids and excitatory amino acid receptors: evidence that b-L-ODAP is a selective non-NMDA agonist. J Neuroscience 9(6):2073-2079 (Pubitemid 19156994)
19. Willis CL, Meldrum BS, Nunn PB, Anderton BH, Leigh PN (1993) Neuronal damage induced by beta-N-oxalylamino-L-alanine, in the rat hippocampus, can be prevented by a non-NMDA antagonist, 2, 3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F) quinoxaline. Brain Res 627(1):55-62 (Pubitemid 23309599)
20. Tshala-Katumbay DD, Spencer PS (2007) Toxic disorders of the upper motor neuron system, Chapter 18. Handb Clin Neuro 82:353-372
21. Sriram K, Shankar SK, Boyd MR, Ravindranath V (1998) Thiol oxidation and loss of mitochondrial complex I precede excitatory amino acid-mediated neurodegeneration. J Neurosci 18(24): 10287-10296 (Pubitemid 29016548)
22. Ravindranath V (2002) NL: mitochondrial dysfunction in excitotoxicity mediated by L-b-oxalyl aminoalanine. Neurochem Int 40(6):505-509 (Pubitemid 34159151)
23. Ganpathy KT, Dwivedi MP (1961) Studies on clinical epidemiology of lathyrism, Lathyrism Enquiry Reid Unit. Indian Council of Medical Research, Ghandi Memorial Hospital, Rewa
24. Cohn DF, Streifler M (1981) Human neurolathyrism, a follow-up study of 200 patients. Part I: clinical investigation. Schweiz Arch Neurol Neurochir Psychiatr 128(1):151-156 (Pubitemid 11045884)
25. Drory VE, Rabey MJ, Cohn DF (1992) Electrophysiologic features in patients with chronic neurolathyrism. Acta Neurol Scand 85:401-403
26. Zaninovic V (2001) Similarities between Tropical Spastic Paraparesis (TSP) and Neurolathyrism. Lathyrus Lathyrism Newsl 2(2):11-14
27. Acton HW (1922) An investigation into the causation of lathynsm in man. Indian Med Gaz 57:241-247
28. Dwivedi MP, Prasad VG (1964) An epidemiological study of lathyrism in the district of Rewa, Madhya Pradesh. Indian J Med Res 52:81-114
29. Getahun H, Lambien F, Van der Stuyft P (2002) ABO blood groups, grass pea preparation, and neurolathyrism in Ethiopia. Trans R Soc Trop Med Hyg 96(6):700-703 (Pubitemid 36231500)
30. Getahun H, Lambein F, Vanhoorne M, Van der Stuyft P (2005) Neurolathyrism risk depends on type of grass pea preparation and on mixing with cereals and antioxidant. Trop Med Int Health 10(2):169-178 (Pubitemid 40269167)
31. Gardner AF, Sakiewicz N (1963) A review of neurolathyrism including the Russian and Polish literature. Exp Med Surg 21:164-191
32. Gopalan C (1950) The lathyrism syndrome. Trans R Soc Trop Med Hyg 44(3):333-338
33. Fikre A, Lambien F, Gheysen G (2006) A life-saving food plant producing more neurotoxin under environmental stress. Commun Agric Appl Biol Sci 71(1):79-82
34. Ludolph AR, Gimenez-Roldan S, Hugon J, Dumas JL, Spencer PS (1990) Electrophysiological evaluation of human lathyrism-results in Bangladesh and Spain. Lathyrus Lathyrism Newsl 2:9
35. Cantani A (1873) Latirismo (Lathyrismus) illustrato da tre casi clinici. Morgagni 15:745
36. Proust A (1883) Du lathyrisme medullaire spasmodique. Bull Acad Med 12:839
37. Filimonoff I (1926) Zur pathologisch-anatomischen Charakteristik des Lathyrismus. Ztschr Ges Neurol Psychiat 105:76-92
38. Buzzard E, Greenfield JG (1921) Pathology of the nervous system. Constable, London
39. Puig JS, DeVinals RR (1943) Aportacion a la patologia del latirismo. Rev Clin Esp 8:107
40. Sachdev S, Sachdev JC, Pun D, Devider P (1969) Morphological study in a case of lathyrism. J Indian Med Assoc 52:320
41. Striefler M, Cohn DF, Hirano A, Schujman E (1977) The central nervous systemin a case of neurolathyrism. Neurology 27(12):1176-1178 (Pubitemid 8260736)
42. Hirano A, Llena JF, Streifler M, Cohn DF (1976) Anterior horn changes in a case of neurolathyrism. Acta Neuropathol (Berl) 35:277-283
43. Cohn DF, Streifler M (1981) Human neurolathyrism, a follow-up study. Part II: special investigations. Schweiz Arch Neurol Neurochir Psychiatr 128(1):157-163 (Pubitemid 11045885)
44. Leite AC, Mendonca GA, Serpa MJ, Nascimento OJ, Araujo AQ (2003) Neurological manifestations in HTLV-Iinfected blood donors. J Neurol Sci 214:49-56 (Pubitemid 37100981)
45. Silva MT, Mattos P, Alfano A, Araujo AQ (2003) Neuropsychological assessment in HTLV-1 infection: a comparative study among TSP/HAM, asymptomatic carriers, and healthy controls. J Neurol Neurosurg Psychiatry 74:1085-1089
46. Boissé L, Gill MJ, Power C (2008) HIV infection of the central nervous system: clinical features and neuropathogenesis. Neurol Clin 26(3):799-819 (Pubitemid 352037443)
47. Adish AA, Esrey SA, Gyorkos TW, Jean-Baptiste J, Rojhani A (1999) Effect of consumption of food cooked in iron pots on iron status and growth of young children: a randomised trial. Lancet 353:712-716 (Pubitemid 29103805)
48. Chu YF, Sun J, Wu XZ, Liu RH (2002) Antioxidant and antiproliferative activities of common vegetables. J Agric Food Chem 50:6910-6916 (Pubitemid 35253192)
49. Kuo YH, Bau HM, Quemener B, Khan JK, Lambein F (1995) Solid state fermentation of Lathyrus sativus seeds using Aspergillus oryzae and Rhizopus oligosprus sp T-3 to eliminate the neurotoxin b-ODAP without loss of nutritional value. J Sci Food Agric 69:81-89
50. Akalu G, Johansson G, Nair BM (1998) Effect of processing on the content of b-N-oxalyl-a, b-diaminopropionic acid (b-ODAP) in grass pea (Lathyrus sativus) seeds and flour as determined by flow injection analysis. Food Chem 62:233-237 (Pubitemid 28327664)
51. Santhaand M, Mehta SL (2008) Handbook of New technologies for Genetic Improvement of legumes. Kirti PB (ed) CRC Press, pp 177-185
52. Fikre A, Van Moorhem M, Ahmed S, Lambein F, Gheysen G (2011) Studies on neurolathyrism in Ethiopia: dietary habits, perception of risks and prevention. Food Chem Toxicol 49(3):678-684