Regulations of astrocytic functions by endothelins: Roles in the pathophysiological responses of damaged brains

Journal of Pharmacological Sciences

Volumn 118, Issue 4, 2012, Pages 401-407

  Koyama, Yutaka ^a   Michinaga, Shotaro ^a  

^a OSAKA OHTANI UNIVERSITY   (Japan)

Author keywords

Astrocyte; Brain edema; Endothelin; Neuroprotection

Indexed keywords

ENDOTHELIN; ENDOTHELIN RECEPTOR; MATRIX METALLOPROTEINASE; NEUROPROTECTIVE AGENT; NEUROTROPHIC FACTOR; VASCULOTROPIN;

ASTROCYTE; BLOOD VESSEL PERMEABILITY; BRAIN DAMAGE; BRAIN EDEMA; BRAIN FUNCTION; CELL FUNCTION; CELL PROLIFERATION; CELL PROTECTION; CELL REGENERATION; CELL STRUCTURE; CYTOSKELETON; DRUG MECHANISM; DRUG TARGETING; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW;

EID: 84864283757     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.11R13CP     Document Type: Review

References (30)

1. Schinelli S. Pharmacology and physiopathology of the brain endothelin system: an overview. Curr Med Chem. 2006;13: 627-638.
2. Ostrow LW, Sachs F. Mechanosensation and endothelin in astrocytes - hypothetical roles in CNS pathophysiology. Brain Res Brain Res Rev. 2005;48:488-508.
3. Nie XJ, Olsson Y. Endothelin peptides in brain diseases. Rev Neurosci. 1996;7:177-186.
4. Sofroniew MV. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009;32:638-647.
5. Hamby ME, Sofroniew MV. Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics. 2010;7:494-506.
6. Ishikawa N, Takemura M, Koyama Y, Shigenaga Y, Okada T, Baba A. Endothelins promote the activation of astrocytes in rat neostriatum through ETB receptors. Eur J Neurosci. 1997;9:895-901.
7. Koyama Y, Takemura M, Fujiki K, Ishikawa N, Shigenaga Y, Baba A. BQ788, an endothelin ETB receptor antagonist attenuates stab wound injury-induced reactive astrocytes in rat brain. Glia. 1999;26:268-271.
8. Peters CM, Rogers SD, Pomonis JD, Egnaczyk GF, Keyser CP, Schmidt JA, et al. Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis. Exp Neurol. 2003;180:1-13.
9. Rogers SD, Peters CM, Pomonis JD, Hagiwara H, Ghilardi JR, Mantyh PW. Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS. Glia. 2003;41:180-190.
10. Wilhelmsson U, Li L, Pekna M, Berthold CH, Blom S, Eliasson C, et al. Absence of glial fibrillary acidic protein and vimentin prevents hypertrophy of astrocytic processes and improves post-traumatic regeneration. J Neurosci. 2004;24:5016-5021.
11. Ehrenreich H, Anderson RW, Ogino Y, Rieckmann P, Costa T, Wood GP, et al. Selective autoregulation of endothelins in primary astrocyte cultures: endothelin receptor-mediated potentiation of endothelin-1 secretion. New Biol. 1991;3:135-141.
12. Gadea A, Schinelli S, Gallo V. Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway. J Neurosci. 2008;28:2394-2408.
13. Uesugi M, Kasuya Y, Hama H, Yamamoto M, Hayashi K, Masaki T, et al. Endogenous endothelin-1 initiates astrocytic growth after spinal cord injury. Brain Res. 1996;28:255-259.
14. Koyama Y, Yoshioka Y, Hashimoto H, Matsuda T, Baba A. Endothelins increase tyrosine phosphorylation of astrocytic focal adhesion kinase and paxillin accompanied with their association with cytoskeletal components. Neuroscience. 2000;101:219-227.
15. Koyama Y, Yoshioka Y, Shinde M, Matsuda T, Baba A. Focal adhesion kinase mediates endothelin-induced cyclin D3 expression in rat cultured astrocytes. J Neurochem. 2004;90:904-912.
16. Koyama Y, Yoshioka Y, Matsuda T, Baba A. Focal adhesion kinase is required for endothelin-induced cell cycle progression of astrocytes. Glia. 2003;43:185-189.
17. Koyama Y, Tsujikawa K, Matsuda T, Baba A. Intracerebroventricular administration of an endothelin ETB receptor agonist increases expressions of GDNF and BDNF in rat brain. Eur J Neurosci. 2003;18:887-894.
18. Koyama Y, Baba A, Matsuda T. Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes. Neuroscience. 2005;136:425-433.
19. Koyama Y, Tsujikawa K, Matsuda T, Baba A. Endothelin-1 stimulates GDNF expression in cultured rat astrocytes. Biochem Biophys Res Commun. 2003;303:1101-1105.
20. Ladenheim RG, Lacroix I, Foignant-Chaverot N, Strosberg AD, Couraud PO. Endothelins stimulate c-fos and nerve growth factor expression in astrocytes and astrocytoma. J Neurochem. 1993;60:260-266.
21. Blesch A. Neurotrophic factors in neurodegeneration. Brain Pathol. 2006;16:295-303.
22. Koyama Y, Tanaka K. Intracerebroventricular administration of an endothelin ETB-receptor agonist increases expression of matrix metalloproteinase-2 and -9 in rat brain. J Pharmacol Sci. 2010;114:433-443.
23. Koyama Y, Nagae R, Tokuyama S, Tanaka K. I.c.v administration of an endothelin ETB receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular endothelial growth factor receptors in rat brain. Neuroscience. 2011;192:689-698.
24. Candelario-Jalil E, Yang Y, Rosenberg GA. Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience. 2009;158:983-994.
25. Kumai Y, Ooboshi H, Ibayashi S, Ishikawa E, Sugimori H, Kamouchi M, et al. Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability. J Cereb Blood Flow Metab. 2007;27:1152-1160.
26. Manley GT, Fujimura M, Ma T, Noshita N, Filiz F, Bollen AW, et al. Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke. Nat Med. 2000;6:159-163.
27. Koyama Y, Tanaka K. Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ETB receptor agonist. Neurosci Lett. 2010;469:343-347.
28. Tanaka K, Koyama Y. Endothelins decrease the expressions of aquaporins and plasma membrane water permeability in cultured rat astrocytes. J Neurosci Res. 2011;89:320-328.
29. Vidovic M, Chen MM, Lu QY, Kalloniatis KF, Martin BM, Tan AH, et al. Deficiency in endothelin receptor B reduces proliferation of neuronal progenitors and increases apoptosis in postnatal rat cerebellum. Cell Mol Neurobiol. 2008;28:1129-1138.
30. Yagami T, Ueda K, Sakaeda T, Okamura N, Nakazato H, Kuroda T, et al. Effects of an endothelin B receptor agonist on secretory phospholipase A2-IIA-induced apoptosis in cortical neurons. Neuropharmacology. 2005;48:291-300.