The effect of coenzyme Q 10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: An open-label prospective study

International Urology and Nephrology

Volumn 44, Issue 3, 2012, Pages 689-700

  Safarinejad, Mohammad Reza ^a  

^a Clinical Center for Urological Disease Diagnosis   (Iran)

Author keywords

CoQ 10; Male factor infertility; Pregnancy rate; Semen parameters; Supplementation; Treatment

Indexed keywords

CATALASE; FOLLITROPIN; INHIBIN B; LUTEINIZING HORMONE; SEX HORMONE; SUPEROXIDE DISMUTASE; UBIDECARENONE;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL EVALUATION; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; FOLLITROPIN BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; OLIGOSPERMIA; PREGNANCY RATE; SEMEN ANALYSIS; SEMINAL PLASMA; SEX HORMONE DETERMINATION; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TREATMENT DURATION; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT;

ADULT; ANALYSIS OF VARIANCE; CATALASE; DIETARY SUPPLEMENTS; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY, MALE; INHIBINS; LUTEINIZING HORMONE; MALE; OLIGOSPERMIA; PREGNANCY; PREGNANCY RATE; PROLACTIN; SEMEN; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SUPEROXIDE DISMUTASE; TESTOSTERONE; THYROTROPIN; UBIQUINONE; VITAMINS; YOUNG ADULT;

EID: 84864279309     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-011-0081-0     Document Type: Article

References (28)

1. World Health Organisation (2002) Current practices and controversies in assisted production. Geneva, Switzerland
2. Safarinejad MR (2008) Infertility among couples in a population-based study in Iran: prevalence and associated risk factors. Int J Androl 31:303-314 (Pubitemid 351652025)
3. World Health Organization (1992) The influence of varicocele on parameters of fertility in a large group of men presenting to fertility clinics. Fertil Steril 57:1289
4. Dennerstein L, Morse C (1988) A review of psychological and social aspects of in vitro fertilization. J Psychosom Obstet Gynaecol 9:159-170 (Pubitemid 19007829)
5. Miesel R, Jedrzejczac P, Sanocka D, Kurpisz MK (1997) Severe antioxidase deficiency in human semen samples with pathological spermiogram parameters. Andrologia 29: 77-83 (Pubitemid 27165413)
6. Safarinejad MR, Safarinejad S (2009) Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol 181:741-751
7. Nohl H, Gille L, Kozlou AV (1999) Critical aspects of the antioxidant function of coenzyme Q in biomembranes. BioFactors 9:155-161 (Pubitemid 29288993)
8. Bhagavan HN, Chopra RK (2007) Plasma coenzyme Q10 response to oral ingestion of coenzyme Q10 formulations. Mitochondrion 7S:S78-S88 (Pubitemid 46712234)
9. Balercia G, Buldreghini E, Vignini A et al (2009) Coenzyme Q(10) treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril 91:1785-1792
10. Safarinejad MR(2009) Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol 182:237-248
11. Kumar R, Gautam G, Gupta NP (2006) Drug therapy for idiopathic male infertility: rationale versus evidence. J Urol 176:1307-1312 (Pubitemid 44307189)
12. World Health Organization (1999) WHOlaboratory manual for the examination of human semen and sperm-cervical mucus interaction, 4th edn. Cambridge University Press, New York
13. Kruger TF, Menkveld R, Stander FS et al (1986) Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril 46:1118-1123 (Pubitemid 17215837)
14. Ikematsu H, Nakamura K, Harashima S et al (2006) Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 44:212-218
15. Safarinejad MR (2010) Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study. Andrologia 41:1-10
16. Zini A, Fischer MA, Mak V et al (2002) Catalase-like and superoxide dismutase-like activities in human seminal plasma. Urol Res 30:321-323 (Pubitemid 36056642)
17. Yeung CH, De Geyter C, De Geyter M et al (1996) Production of reactive oxygen species by and hydrogen peroxide scavenging activity of spermatozoa in an IVF program. J Assist Reprod Genet 13:495-500 (Pubitemid 26238801)
18. Mahdi AA, Bano F, Singh R et al (1999) Seminal plasma superoxide dismutase and catalase activities in infertile men. Med Sci Res 27:201-203 (Pubitemid 29338910)
19. Mancini A, Milardi D, Conte G et al (2003) Coenzyme Q10: another biochemical alteration linked to infertility in varicocele patients? Metabolism 52:402-406 (Pubitemid 36773259)
20. Iwasaki A, Gagnon C (1992) Formation of reactive oxygen species in spermatozoa of infertile patients. Fertil Steril 57:409-416
21. Ernster L, Forsmark-Andrée P (1993) Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Invest 71:S60-S65
22. Bliznakov EG (1999) Cardiovascular diseases, oxidative stress and antioxidants: the decisive role of coenzyme Q10. Cardiovasc Res 43:248-249 (Pubitemid 29322885)
23. Balercia G, Mosca F, Mantero F et al (2004) Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril 81:93-98 (Pubitemid 38058332)
24. Evers JL, de Haas HW, Land JA et al (1998) Treatmentindependent pregnancy rate in patients with severe reproductive disorders. Hum Reprod 13:1206-1209 (Pubitemid 28279171)
25. Said RM, Agarwal A, Sharma RK et al (2004) Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility. Fertil Steril 82: 871-874
26. Agarwal A, Gupta S, Sikka S (2006) The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol 18:325-332 (Pubitemid 43864734)
27. Serour GI (2002) Attitudes and cultural perspectives on infertility and its alleviation in the Middle East area. In: Vayena E, Rowe PJ, Griffin PD (eds) Current practices and controversies in assisted reproduction. World Health Organization, Geneva, pp 41-49
28. de Kok BC, Widdicombe S (2008) 'I really tried': management of normative issues in accounts of responses to infertility. Soc Sci Med 67:1083-1093