메뉴 건너뛰기




Volumn 60, Issue 5, 2012, Pages 455-461

Retrocyclin RC-101 blocks HIV-1 transmission across cervical mucosa in an organ culture

Author keywords

HIV; microbicide; organ culture; retrocyclin

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; POLYPEPTIDE ANTIBIOTIC AGENT; RC 101; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84864279218     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e318258b420     Document Type: Article
Times cited : (9)

References (50)
  • 1
    • 0347032797 scopus 로고    scopus 로고
    • Women's interest in vaginal microbicides
    • DOI 10.2307/2991552
    • Darroch JE, Frost JJ. Women's interest in vaginal microbicides. Fam Plann Perspect. 1999;31:16-23. (Pubitemid 29072111)
    • (1999) Family Planning Perspectives , vol.31 , Issue.1 , pp. 16-23
    • Darroch, J.E.1    Frost, J.J.2
  • 2
    • 33748990336 scopus 로고    scopus 로고
    • Which topical microbicides for blocking HIV-1 transmission will work in the real world?
    • Klasse PJ, Shattock RJ, Moore JP. Which topical microbicides for blocking HIV-1 transmission will work in the real world? PLoS Med. 2006;3:e351.
    • (2006) PLoS Med , vol.3
    • Klasse, P.J.1    Shattock, R.J.2    Moore, J.P.3
  • 3
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science. 2010;329:1168-1174.
    • (2010) Science , vol.329 , pp. 1168-1174
    • Abdool Karim, Q.1    Abdool Karim, S.S.2    Frohlich, J.A.3
  • 6
    • 0030997133 scopus 로고    scopus 로고
    • Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: Retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase
    • Borkow G, Barnard J, Nguyen TM, et al. Chemical barriers to human immunodeficiency virus type 1 (HIV-1) infection: retrovirucidal activity of UC781, a thiocarboxanilide nonnucleoside inhibitor of HIV-1 reverse transcriptase. J Virol. 1997;71:3023-3030. (Pubitemid 27119946)
    • (1997) Journal of Virology , vol.71 , Issue.4 , pp. 3023-3030
    • Borkow, G.1    Barnard, J.2    Nguyen, T.M.3    Belmonte, A.4    Wainberg, M.A.5    Parniak, M.A.6
  • 7
    • 0023201996 scopus 로고
    • Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro
    • DOI 10.1016/0166-3542(87)90018-0
    • Ito M, Baba M, Sato A, et al. Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro. Antiviral Res. 1987;7:361-367. (Pubitemid 17101065)
    • (1987) Antiviral Research , vol.7 , Issue.6 , pp. 361-367
    • Ito, M.1    Baba, M.2    Sato, A.3
  • 8
    • 0031861195 scopus 로고    scopus 로고
    • Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains
    • Srinivas RV, Fridland A. Antiviral activities of 9-R-2- phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains. Antimicrob Agents Chemother. 1998;42:1484-1487. (Pubitemid 28257654)
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , Issue.6 , pp. 1484-1487
    • Srinivas, R.V.1    Fridland, A.2
  • 11
    • 0034033172 scopus 로고    scopus 로고
    • Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract
    • DOI 10.1038/74743
    • Collins KB, Patterson BK, Naus GJ, et al. Development of an in vitro organ culture model to study transmission of HIV-1 in the female genital tract. Nat Med. 2000;6:475-479. (Pubitemid 30208169)
    • (2000) Nature Medicine , vol.6 , Issue.4 , pp. 475-479
    • Collins, K.B.1    Patterson, B.K.2    Naus, G.J.3    Landers, D.V.4    Gupta, P.5
  • 12
    • 4444280943 scopus 로고    scopus 로고
    • Hydrocephalus in a newborn bottlenosed dolphin (Tursiops truncatus)
    • Corpa JM, Peris B, Ribes V, et al. Hydrocephalus in a newborn bottlenosed dolphin (Tursiops truncatus). Vet Rec. 2004;155:208-210. (Pubitemid 39193946)
    • (2004) Veterinary Record , vol.155 , Issue.7 , pp. 208-210
    • Corpa, J.M.1    Peris, B.2    Ribes, V.3    Palacio, J.4    Liste, F.5
  • 15
    • 33745842280 scopus 로고    scopus 로고
    • Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides
    • DOI 10.1097/01.aids.0000232230.96134.80, PII 0000203020060612000003
    • Fletcher PS, Elliott J, Grivel JC, et al. Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides. AIDS. 2006;20:1237-1245. (Pubitemid 44030371)
    • (2006) AIDS , vol.20 , Issue.9 , pp. 1237-1245
    • Fletcher, P.S.1    Elliott, J.2    Grivel, J.-C.3    Margolis, L.4    Anton, P.5    McGowan, I.6    Shattock, R.J.7
  • 16
    • 0034034688 scopus 로고    scopus 로고
    • Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides
    • DOI 10.1128/JVI.74.12.5577-5586.2000
    • Greenhead P, Hayes P, Watts PS, et al. Parameters of human immunodeficiency virus infection of human cervical tissue and inhibition by vaginal virucides. J Virol. 2000;74:5577-5586. (Pubitemid 30346592)
    • (2000) Journal of Virology , vol.74 , Issue.12 , pp. 5577-5586
    • Greenhead, P.1    Hayes, P.2    Watts, P.S.3    Laing, K.G.4    Griffin, G.E.5    Shattock, R.J.6
  • 18
    • 0037471277 scopus 로고    scopus 로고
    • Blocking of cell-free and cell-associated HIV-1 transmission through human cervix organ culture with UC781
    • DOI 10.1097/00002030-200303280-00002
    • Zussman A, Lara L, Lara HH, et al. Blocking of cell-free and cellassociated HIV-1 transmission through human cervix organ culture with UC781. AIDS. 2003;17:653-661. (Pubitemid 36521071)
    • (2003) AIDS , vol.17 , Issue.5 , pp. 653-661
    • Zussman, A.1    Lara, L.2    Lara, H.H.3    Bentwich, Z.4    Borkow, G.5
  • 19
    • 0036776324 scopus 로고    scopus 로고
    • + T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system
    • DOI 10.1128/JVI.76.19.9868-9876.2002
    • Gupta P, Collins KB, Ratner D, et al. Memory CD4(+) T cells are the earliest detectable human immunodeficiency virus type 1 (HIV-1)-infected cells in the female genital mucosal tissue during HIV-1 transmission in an organ culture system. J Virol. 2002;76:9868-9876. (Pubitemid 35006526)
    • (2002) Journal of Virology , vol.76 , Issue.19 , pp. 9868-9876
    • Gupta, P.1    Collins, K.B.2    Ratner, D.3    Watkins, S.4    Naus, G.J.5    Landers, D.V.6    Patterson, B.K.7
  • 22
    • 0032552228 scopus 로고    scopus 로고
    • A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases
    • DOI 10.1056/NEJM199808203390803
    • Roddy RE, Zekeng L, Ryan KA, et al. A controlled trial of nonoxynol 9 film to reduce male-to-female transmission of sexually transmitted diseases. N Engl J Med. 1998;339:504-510. (Pubitemid 28384883)
    • (1998) New England Journal of Medicine , vol.339 , Issue.8 , pp. 504-510
    • Roddy, R.E.1    Zekeng, L.2    Ryan, K.A.3    Tamoufe, U.4    Weir, S.S.5    Wong, E.L.6
  • 24
    • 39849100140 scopus 로고    scopus 로고
    • Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir
    • Garcia-Lerma JG, Otten RA, Qari SH, et al. Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir. PLoS Med. 2008;5:e28.
    • (2008) PLoS Med , vol.5
    • Garcia-Lerma, J.G.1    Otten, R.A.2    Qari, S.H.3
  • 25
    • 33847101873 scopus 로고    scopus 로고
    • Dose-ranging phase 1 study of TMC120, a promising vaginal microbicide, in HIV-negative and HIV-positive female volunteers
    • DOI 10.1097/QAI.0b013e31802bb35f, PII 0012633420070201000005
    • Jespers VA, Van Roey JM, Beets GI, et al. Dose-ranging phase 1 study of TMC120, a promising vaginal microbicide, in HIV-negative and HIV-positive female volunteers. J Acquir Immune Defic Syndr. 2007; 44:154-158. (Pubitemid 46292217)
    • (2007) Journal of Acquired Immune Deficiency Syndromes , vol.44 , Issue.2 , pp. 154-158
    • Jespers, V.A.1    Van Roey, J.M.2    Beets, G.I.3    Buve, A.M.4
  • 28
    • 69949109909 scopus 로고    scopus 로고
    • Quarraisha abdool karim: Investigating hiv/aids in south africa. Interview by priva shetty
    • Karim QA. Quarraisha Abdool Karim: investigating HIV/AIDS in South Africa. Interview by Priva Shetty. Lancet. 2009;374:871.
    • (2009) Lancet , vol.374 , pp. 871
    • Karim, Q.A.1
  • 31
    • 34147186687 scopus 로고    scopus 로고
    • Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes
    • DOI 10.1016/j.virol.2007.03.001, PII S0042682207001420
    • Ketas TJ, Schader SM, Zurita J, et al. Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes. Virology. 2007;364:431-440. (Pubitemid 46873705)
    • (2007) Virology , vol.364 , Issue.2 , pp. 431-440
    • Ketas, T.J.1    Schader, S.M.2    Zurita, J.3    Teo, E.4    Polonis, V.5    Lu, M.6    Klasse, P.J.7    Moore, J.P.8
  • 35
    • 79955528232 scopus 로고    scopus 로고
    • Formulation development of retrocyclin 1 analog rc-101 as an anti-hiv vaginal microbicide product
    • Sassi AB, Cost MR, Cole AL, et al. Formulation development of retrocyclin 1 analog RC-101 as an anti-HIV vaginal microbicide product. Antimicrob Agents Chemother. 2011;55:2282-2289.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2282-2289
    • Sassi, A.B.1    Cost, M.R.2    Cole, A.L.3
  • 36
    • 0031054936 scopus 로고    scopus 로고
    • + T-cell-mediated suppression of human immunodeficiency virus type 1 infection
    • Chen Y, Rinaldo C, Gupta P. A semiquantitative assay for CD8+ T-cellmediated suppression of human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol. 1997;4:4-10. (Pubitemid 27063693)
    • (1997) Clinical and Diagnostic Laboratory Immunology , vol.4 , Issue.1 , pp. 4-10
    • Chen, Y.1    Rinaldo, C.2    Gupta, P.3
  • 37
    • 47049102581 scopus 로고    scopus 로고
    • Infection with Vpr-positive human immunodeficiency virus type 1 impairs NK cell function indirectly through cytokine dysregulation of infected target cells
    • DOI 10.1128/JVI.01979-07
    • Majumder B, Venkatachari NJ, O'Leary S, et al. Infection with Vprpositive human immunodeficiency virus type 1 impairs NK cell function indirectly through cytokine dysregulation of infected target cells. J Virol. 2008;82:7189-7200. (Pubitemid 351977736)
    • (2008) Journal of Virology , vol.82 , Issue.14 , pp. 7189-7200
    • Majumder, B.1    Venkatachari, N.J.2    O'Leary, S.3    Ayyavoo, V.4
  • 38
    • 70349667814 scopus 로고    scopus 로고
    • Multiple t-cell responses to human immunodeficiency virus type 1 are enhanced by dendritic cells
    • Huang XL, Fan Z, Borowski L, et al. Multiple T-cell responses to human immunodeficiency virus type 1 are enhanced by dendritic cells. Clin Vaccine Immunol. 2009;16:1504-1516.
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 1504-1516
    • Huang, X.L.1    Fan, Z.2    Borowski, L.3
  • 39
    • 45949086664 scopus 로고    scopus 로고
    • Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection
    • Qin S, Sui Y, Soloff AC, et al. Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection. J Immunol. 2008;180:5530-5536.
    • (2008) J Immunol , vol.180 , pp. 5530-5536
    • Qin, S.1    Sui, Y.2    Soloff, A.C.3
  • 40
    • 0026196420 scopus 로고
    • The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa
    • Niruthisard S, Roddy RE, Chutivongse S. The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa. Sex Transm Dis. 1991; 18:176-179.
    • (1991) Sex Transm Dis , vol.18 , pp. 176-179
    • Niruthisard, S.1    Roddy, R.E.2    Chutivongse, S.3
  • 41
    • 0036792716 scopus 로고    scopus 로고
    • Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model
    • Patton DL, Cosgrove Sweeney YT, Rabe LK, et al. Rectal applications of nonoxynol-9 cause tissue disruption in a monkey model. Sex Transm Dis. 2002;29:581-587.
    • (2002) Sex Transm Dis , vol.29 , pp. 581-587
    • Patton, D.L.1    Cosgrove Sweeney, Y.T.2    Rabe, L.K.3
  • 43
    • 65949105709 scopus 로고    scopus 로고
    • Reawakening retrocyclins: Ancestral human defensins active against hiv-1
    • Venkataraman N, Cole AL, Ruchala P, et al. Reawakening retrocyclins: ancestral human defensins active against HIV-1. PLoS Biol. 2009;7:e95.
    • (2009) PLoS Biol , vol.7
    • Venkataraman, N.1    Cole, A.L.2    Ruchala, P.3
  • 44
    • 48249154985 scopus 로고    scopus 로고
    • Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    • Van Damme L, Govinden R, Mirembe FM, et al. Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. N Engl J Med. 2008;359:463-472.
    • (2008) N Engl J Med , vol.359 , pp. 463-472
    • Van Damme, L.1    Govinden, R.2    Mirembe, F.M.3
  • 46
    • 85012474693 scopus 로고
    • Mechanisms of disease: The immunopathogenesis of human immunodeficiency virus infection
    • DOI 10.1056/NEJM199302043280508
    • Pantaleo G, Graziosi C, Fauci AS. New concepts in the immunopathogenesis of human immunodeficiency virus infection. N Engl J Med. 1993;328:327-335. (Pubitemid 23035333)
    • (1993) New England Journal of Medicine , vol.328 , Issue.5 , pp. 327-335
    • Pantaleo, G.1    Graziosi, C.2    Fauci, A.S.3
  • 47
    • 0026511126 scopus 로고
    • The effect of cytokines and pharmacologic agents on chronic HIV infection
    • Poli G, Fauci AS. The effect of cytokines and pharmacologic agents on chronic HIV infection. AIDS Res Hum Retroviruses. 1992;8: 191-197.
    • (1992) AIDS Res Hum Retroviruses , vol.8 , pp. 191-197
    • Poli, G.1    Fauci, A.S.2
  • 48
    • 78649749939 scopus 로고    scopus 로고
    • The formulated microbicide rc-101 was safe and antivirally active following intravaginal application in pigtailed macaques
    • Cole AM, Patton DL, Rohan LC, et al. The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. PLoS One. 2010;5:e15111.
    • (2010) PLoS One , vol.5
    • Cole, A.M.1    Patton, D.L.2    Rohan, L.C.3
  • 49
    • 33646873341 scopus 로고    scopus 로고
    • HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41
    • Cole AL, Yang OO, Warren AD, et al. HIV-1 adapts to a retrocyclin with cationic amino acid substitutions that reduce fusion efficiency of gp41. J Immunol. 2006;176:6900-6905. (Pubitemid 43787871)
    • (2006) Journal of Immunology , vol.176 , Issue.11 , pp. 6900-6905
    • Cole, A.L.1    Yang, O.O.2    Warren, A.D.3    Waring, A.J.4    Lehrer, R.I.5    Cole, A.M.6
  • 50
    • 1042302158 scopus 로고    scopus 로고
    • Evolution of primate θ-defensins: A serpentine path to a sweet tooth
    • DOI 10.1016/j.peptides.2003.07.023
    • Nguyen TX, Cole AM, Lehrer RI. Evolution of primate theta-defensins: a serpentine path to a sweet tooth. Peptides. 2003;24:1647-1654. (Pubitemid 38198072)
    • (2003) Peptides , vol.24 , Issue.11 , pp. 1647-1654
    • Nguyen, T.X.1    Cole, A.M.2    Lehrer, R.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.