Anti-cancer activity and mutagenic potential of novel copper(II) quinolinone Schiff base complexes in hepatocarcinoma cells

European Journal of Pharmacology

Volumn 689, Issue 1-3, 2012, Pages 45-55

  Duff, Brian ^a   Reddy Thangella, Venkat ^a   Creaven, Bernadette S ^a   Walsh, Maureen ^a   Egan, Denise A ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

Copper(II); Hepatocellular carcinoma; Mutagenicity; Quinolinones; Topoisomerase II

Indexed keywords

7 (2 HYDROXY 3 METHOXYBENZYLIDEAMINO) 4 METHYLQUINOLIN 2 [1H]ONE; 7 (2 HYDROXY 4 METHOXYBENZYLIDEAMINO) 4 METHYLQUINOLIN 2 [1H]ONE; 7 (2 HYDROXYBENZYLIDEAMINO) 4 METHYLQUINOLIN 2 [1H]ONE; 7 (2,3 DIHYDROXYBENZYLIDEAMINO) 4 METHYLQUINOLIN 2 [1H]ONE; 7 (3 ETHOXY 2 HYDROXYBENZYLIDEAMINO) 4 METHYLQUINOLIN 2 [1H]ONE; BROXURIDINE; CISPLATIN; COPPER COMPLEX; DNA TOPOISOMERASE; GLYCOPROTEIN P; QUINOLINE SCHIFF BASE COPPER COMPLEX; QUINOLINOL DERIVATIVE; SCHIFF BASE; UNCLASSIFIED DRUG;

AMES TEST; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL ASSAY; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DRUG SELECTIVITY; DRUG TARGETING; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN TISSUE; IC 50; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CELL SURVIVAL; CHO CELLS; COPPER; CRICETINAE; CRICETULUS; HELA CELLS; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MALE; MUTAGENESIS; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; SCHIFF BASES;

EID: 84864277689     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.06.004     Document Type: Article

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