Thymic carcinoma, Part 1: A clinicopathologic and immunohistochemical study of 65 cases

American Journal of Clinical Pathology

Volumn 138, Issue 1, 2012, Pages 103-114

  Weissferdt, Annikka ^a   Moran, Cesar A ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Immunohistochemistry; Masaoka staging system; Mediastinum; Thymic carcinoma; Thymus

Indexed keywords

CALRETININ; CD205 PROTEIN; CD30 ANTIGEN; CD5 ANTIGEN; CYTOKERATIN; CYTOKERATIN 5; CYTOKERATIN 6; CYTOKERATIN 7; FOXN1 PROTEIN; NAPSIN A; PROTEIN; PROTEIN P63; STEM CELL FACTOR; THYROID TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR PAX8; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; ANAPLASTIC CARCINOMA; ARM PAIN; ARTICLE; BACKACHE; CANCER ADJUVANT THERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; CLEAR CELL CARCINOMA; CLINICAL ASSESSMENT TOOL; COUGHING; DISEASE SEVERITY; FATIGUE; FEMALE; FEVER; FOLLOW UP; HEART PALPITATION; HIP PAIN; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPHOEPITHELIOMA; MAJOR CLINICAL STUDY; MALAISE; MALE; MASAOKA STAGING SYSTEM; NIGHT SWEAT; OVERALL SURVIVAL; PAPILLARY CARCINOMA; PARESTHESIA; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SPINDLE CELL CARCINOMA; SQUAMOUS CELL CARCINOMA; SURVIVAL TIME; THORAX PAIN; THYMECTOMY; THYMIC CARCINOMA; THYMUS CANCER; TUMOR VOLUME; UNDIFFERENTIATED CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; CARCINOMA; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; SURVIVAL RATE; THYMECTOMY; THYMUS NEOPLASMS; TREATMENT OUTCOME;

EID: 84864247751     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCP88FZTWANLRCB     Document Type: Article

References (41)

1. Travis WD, Brambilla E, Müller-Hermelink HK, et al, eds. WHO Classification of Tumours: Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart. Lyon, France: IARC Press; 2004:148-197.
2. Suster S, Rosai J. Thymic carcinoma: a clinicopathologic study of 60 cases. Cancer. 1991;67:1025-1032.
3. Lee CY, Bae MK, Park IK, et al. Early Masaoka stage and complete resection is important for prognosis of thymic carcinoma: a 20-year experience at a single institution. Eur J Cardiothorac Surg. 2009;36:159-162.
4. Ogawa K, Toita T, Uno T, et al. Treatment and prognosis of thymic carcinoma: a retrospective analysis of 40 cases. Cancer. 2002;94:3115-3119. (Pubitemid 34670493)
5. Liu HC, Hsu WH, Chen YJ, et al. Primary thymic carcinoma. Ann Thorac Surg. 2002;73:1076-1081.
6. Wick MR, Scheithauer BW, Weiland LH, et al. Primary thymic carcinomas. Am J Surg Pathol. 1982;6:613-630. (Pubitemid 13234758)
7. Chalabreysse L, Etienne-Mastroianni B, Adeleine P, et al. Thymic carcinoma: a clinicopathological and immunohistological study of 19 cases. Histopathology. 2004;44:367-374. (Pubitemid 38491304)
8. Truong LD, Mody DR, Cagle PT, et al. Thymic carcinoma: a clinicopathologic study of 13 cases. Am J Surg Pathol. 1990;14:151-166. (Pubitemid 20039011)
9. Moran CA, Suster S. Neuroendocrine carcinomas (carcinoid tumor) of the thymus: a clinicopathologic analysis of 80 cases. Am J Clin Pathol. 2000;114:100-110. (Pubitemid 34453191)
10. Moran CA, Suster S. Mucoepidermoid carcinomas of the thymus: a clinicopathologic study of six cases. Am J Surg Pathol. 1995;19:826-834.
11. Masaoka A, Monden Y, Nakahara K, et al. Follow-up study of thymomas with special reference to their clinical stages. Cancer. 1981;48:2485-2492. (Pubitemid 12228012)
12. Weissferdt A, Moran CA. Anaplastic thymic carcinoma: a clinicopathologic and immunohistochemical study of 6 cases [published online ahead of print November 3, 2011]. Hum Pathol. doi.org/10.1016/j.humpath.2011.07.015.
13. Suster S, Moran CA. Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma: a clinicopathologic study of 22 cases. Am J Surg Pathol. 1996;20:1469-1480. (Pubitemid 26411715)
14. Shimizu J, Hayashi Y, Morita K, et al. Primary thymic carcinoma: a clinicopathological and immunohistochemical study. J Surg Oncol. 1994;56:159-164. (Pubitemid 24226632)
15. Weissferdt A, Moran CA. Thymic carcinoma associated with multilocular thymic cyst: a clinicopathologic study of 7 cases. Am J Surg Pathol. 2011;35:1074-1079.
16. Saad RS, Landreneau RJ, Liu Y, et al. Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum. Appl Immunohistochem Mol Morphol. 2003;11:107-112. (Pubitemid 36749560)
17. Brown JG, Familiari U, Papotti M, et al. Thymic basaloid carcinoma: a clinicopathologic study of 12 cases, with a general discussion of basaloid carcinoma and its relationship with adenoid cystic carcinoma. Am J Surg Pathol. 2009;33:1113-1124.
18. Pan CC, Chen PC, Chou TY, et al. Expression of calretinin and other mesothelioma-related markers in thymic carcinoma and thymoma. Hum Pathol. 2003;34:1155-1162. (Pubitemid 37467001)
19. Suster S, Moran CA. Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. Am J Surg Pathol. 1999;23:691-700. (Pubitemid 29262833)
20. Kojika M, Ishii G, Yoshida J, et al. Immunohistochemical differential diagnosis between thymic carcinoma and type B3 thymoma: diagnostic utility of hypoxic marker, GLUT-1, in thymic epithelial neoplasms. Mod Pathol. 2009;22:1341-1350.
21. Nakagawa K, Matsuno Y, Kunitoh H, et al. Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. Chest. 2005;128:140-144. (Pubitemid 40994465)
22. Pan CC, Chen PC, Chiang H. KIT (CD117) is frequently overexpressed in thymic carcinomas but is absent in thymomas. J Pathol. 2004;202:375-381. (Pubitemid 38325248)
23. Nonaka D, Henley JD, Chiriboga L, et al. Diagnostic utility of thymic epithelial markers CD205 (DEC205) and Foxn1 in thymic epithelial neoplasms. Am J Surg Pathol. 2007;31:1038-1044. (Pubitemid 47012300)
24. Maeda D, Ota S, Ikeda S, et al. Mucinous adenocarcinoma of the thymus: a distinct variant of thymic carcinoma. Lung Cancer. 2009;64:22-27.
25. Toprani TH, Tamboli P, Amin MB, et al. Thymic carcinoma with rhabdoid features. Ann Diagn Pathol. 2003;7:106-111. (Pubitemid 36523045)
26. Pomplun S, Wotherspoon AC, Shah G, et al. Immunohistochemical markers in the differentiation of thymic and pulmonary neoplasms. Histopathology. 2002;40:152-158. (Pubitemid 34122117)
27. Franke A, Ströbel P, Fackeldey V, et al. Hepatoid thymic carcinoma: report of a case. Am J Surg Pathol. 2004;28:250-256. (Pubitemid 38124735)
28. Dorfman DM, Shahsafaei A, Chan JK. Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. Am J Surg Pathol. 1997;21:936-940. (Pubitemid 27402813)
29. Kornstein MJ, Rosai J. CD5 labeling of thymic carcinomas and other nonlymphoid neoplasms. Am J Clin Pathol. 1998;109:722-726. (Pubitemid 28247271)
30. Tateyama H, Eimoto T, Tada T, et al. Immunoreactivity of a new CD5 antibody with normal epithelium and malignant tumors including thymic carcinoma. Am J Clin Pathol. 1999;111:235-240. (Pubitemid 29054952)
31. Weissferdt A, Moran CA. Pax8 expression in thymic epithelial neoplasms: and immunohistochemical analysis. Am J Surg Pathol. 2011;35:1305-1310.
32. Laury AR, Perets R, Piao H, et al. A comprehensive analysis of PAX8 expression in human epithelial tumors. Am J Surg Pathol. 2011;35:816-826.
33. Sangoi AR, West RB, Bonventre JV, et al. Exploring the specificity of putative renal cell carcinoma (RCC) markers in non-renal tissues and neoplasms from various organ systems: a tissue microarray (TMA) study of 501 cases [abstract]. Mod Pathol. 2010;23:216A.
34. Blumberg D, Burt ME, Bains MS, et al. Thymic carcinoma: current staging does not predict prognosis. J Thorac Cardiovasc Surg. 1998;115:303-308.
35. Tsuchiya R, Koga K, Matsuno Y, et al. Thymic carcinoma: proposal for pathological TNM and staging. Pathol Int. 1994;44:505-512. (Pubitemid 24210991)
36. Weide LG, Ulbright TM, Loehrer PJ Sr, et al. Thymic carcinoma: a distinct clinical entity responsive to chemotherapy. Cancer. 1993;71:1219-1223. (Pubitemid 23054909)
37. Chung DA. Thymic carcinoma: analysis of nineteen clinicopathological studies. Thorac Cardiovasc Surg. 2000;48:114-119. (Pubitemid 30304468)
38. Moran CA, Suster S. Mediastinal yolk sac tumors associated with prominent multilocular cystic changes of thymic epithelium: a clinicopathologic and immunohistochemical study of five cases. Mod Pathol. 1997;10:800-803. (Pubitemid 27374850)
39. Moran CA. Germ cell tumors of the mediastinum. Pathol Res Pract. 1999;195:583-587. (Pubitemid 29405763)
40. Suster S, Moran CA. Pleomorphic large cell lymphomas of the mediastinum. Am J Surg Pathol. 1996;20:224-232. (Pubitemid 26038999)
41. Suster S, Moran CA. Primary synovial sarcomas of the mediastinum: a clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases. Am J Surg Pathol. 2005;29:569-578. (Pubitemid 40577865)