Primary synovial sarcomas of the mediastinum: A clinicopathologic, immunohistochemical, and ultrastructural study of 15 cases

American Journal of Surgical Pathology

Volumn 29, Issue 5, 2005, Pages 569-578

  Suster, Saul ^a   Moran, Cesar A ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Mediastinum; Spindle cell tumors; Synovial sarcoma

Indexed keywords

CD99 ANTIGEN; CYTOKERATIN; EPITHELIAL MEMBRANE ANTIGEN; PROTEIN BCL 2; VIMENTIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURGERY; CELL ULTRASTRUCTURE; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOPLASM; DESMOSOME; DIFFERENTIAL DIAGNOSIS; DYSPNEA; ELECTRON MICROSCOPY; EPIDURAL SPACE; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; MEDIASTINUM MASS; PLEURA EFFUSION; ROUGH ENDOPLASMIC RETICULUM; SPINDLE CELL CARCINOMA; SYNOVIAL SARCOMA; THORAX PAIN;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CELL NUCLEUS; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DESMOSOMES; FEMALE; HUMANS; KERATINS; MALE; MEDIASTINAL NEOPLASMS; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; RADIOGRAPHY, THORACIC; SARCOMA, SYNOVIAL; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MARKERS, BIOLOGICAL;

EID: 17744370110     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pas.0000157934.50936.3e     Document Type: Article

References (39)

1. Anton-Pacheco J, Cano I, Cuadros J, et al. Synovial sarcoma of the esophagus. J Pediatr Surg. 1996;31:1703-1705.
2. Brocheriou I, Carnot F, Briere J. Immunohistochemical detection of bcl-2 protein in thymoma. Histopathology. 1995;27:251-255.
3. Cadman NL, Soule EH, Kelly PJ. Synovial sarcoma: an analysis of 134 tumors. Cancer. 1965;18:613-627.
4. Corson JM, Weiss LM, Banks-Schlegel SP, et al. Keratin proteins and carcinoembryonic antigen in synovial sarcomas: an immunohistochemical study of 24 cases. Hum Pathol. 1984;15:615-621.
5. Dickersin GR. Synovial sarcoma: a review and update, with emphasis on the ultrastructural characterization of the nonglandular component. Ultrastruct Pathol. 1991;15:379-402.
6. Evans HL. Synovial sarcoma: a study of 23 biphasic and 17 probable monophasic examples. Pathol Annu. 1980;2:309-331.
7. Fisher C. Synovial sarcoma. Ann Diagn Pathol. 1998;2:401-421.
8. Fisher C. Synovial sarcoma: ultrastructural and immunohistochemical features of epithelial differentiation in monophasic and biphasic tumors. Hum Pathol. 1986;17:996-1008.
9. Fujimoto K, Hashimoto S, Abe T, et al. Synovial sarcoma arising from the chest wall: MR imaging findings. Radiat Med. 1997;15:411-414.
10. Gaertner E, Zeren EH, Fleming MV, et al. Biphasic synovial sarcomas arising in the pleural cavity: a clinicopathologic study of five cases. Am J Surg Pathol. 1996;20:36-45.
11. Ghadially FN. Is synovial sarcoma a carcinosarcoma of connective tissue? Ultrastruct Pathol. 1987;11:147-151.
12. Guillou L, Wadden C, Kraus M, et al. S-100 protein reactivity in synovial sarcomas: a potentially frequent diagnostic pitfall. Immunohistochemical analysis of 100 cases. Appl Immunohistochem. 1996;4:167-175.
13. Heliwell TR, King AP, Raraty M, et al. Biphasic synovial sarcoma in the small intestinal mesentery. Cancer. 1995;75:2862-2866.
14. Iyengar V, Lineberger AS, Kerman S, et al. Synovial sarcoma of the heart: correlation with cytogenetic findings. Arch Pathol Lab Med. 1995;119:1080-1082.
15. Kilpatrick SE, Teot LA, Stanley MW, et al. Fine-needle aspiration biopsy of synovial sarcoma: a cytomorphologic analysis of primary, recurrent, and metastatic tumors. Am J Clin Pathol. 1996;106:769-775.
16. Kleinschmidt-DeMasters B, Mierau GW, Sze C-I, et al. Unusual dural and skull-based mesenchymal neoplasms: a report of four cases. Hum Pathol. 1998;29:240-245.
17. Krall RA, Kostianovsky M, Patchefsky AS. Synovial sarcoma: a clinical, pathological, and ultrastructural study of 26 cases supporting the recognition of a monophasic variant. Am J Surg Pathol. 1981;5:137-151.
18. Leader M, Patel J, Collins M, et al. Synovial sarcoma: true carcinosarcomas? Cancer. 1987;59:2096-2098.
19. Lejars M, Rubens-Duval M. Les sarcomes primitifs des synoviales articulaires. Rev Chir. 1910;41:761-783.
20. Le Marc'hadour F, Pasquier B, Leroux D, et al. Mediastinal synovial sarcoma with t(x;18). Cancer Genet Cytogenet. 1991;55:265-267.
21. Miettinen M, Virtanen I. Synovial sarcoma: a misnomer. Am J Pathol. 1984;117:18-25.
22. Miyashita T, Imamura T, Ishikawa Y, et al. Primary retroperitoneal synovial sarcoma. Intern Med. 1994;33:692-696.
23. Moran CA, Suster S, Koss MN. The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura. Semin Diagn Pathol. 1992;9:169-180.
24. Moran CA, Wick MR, Suster S. The role of immunohistochemistry in the diagnosis of malignant mesothelioma. Semin Diagn Pathol. 2000;17:178-183.
25. Murray MT, Stout AP, Pogogeff IA. Synovial sarcoma and normal synovial tissue cultivated in-vitro. Ann Surg. 1949;31A:619.
26. Nicholson A, Rigby M, Lincoln C, et al. Synovial sarcoma of the heart. Histopathology. 1997;30:340-352.
27. Nielsen GP, Shaw PA, Rosenberg AE, et al. Synovial sarcoma of the vulva: a report of 2 cases. Mod Pathol. 1996;9:970-974.
28. Salisbury JR, Isaacson PG. Synovial sarcoma: an immunohistochemical study. J Pathol. 1985;147:49-57.
29. Shmookler BM. Retroperitoneal synovial sarcoma: a report of four cases. Am J Clin Pathol. 1982;77:686-691.
30. Snover DC, Levine GD, Rosai J. Thymic carcinoma: five distinctive histological variants. Am J Surg Pathol. 1982;6:451-470.
31. Suster S, Fisher C, Moran CA. Expression of bcl-2 oncoprotein in benign and malignant spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinal tract. Am J Surg Pathol. 1998;22:863-872.
32. Suster S, Moran CA. The mediastinum. In: Weidner N, Cote R, Suster S, et al, eds. Modern Surgical Pathology. Philadelphia: Saunders, 2003:439-504.
33. Suster S, Moran CA. Spindle cell thymic carcinoma: clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm. Am J Surg Pathol. 1999;23:691-700.
34. Suster S. Recent advances in the application of immunohistochemical markers for the diagnosis of soft tissue tumors. Semin Diagn Pathol. 2000;17:225-235.
35. Suster S, Rosai J. Thymic carcinoma: a clinicopathologic study of 60 cases. Cancer. 1991;67:1025-1032.
36. Trupiano JK, Rice TW, Herzog K, et al. Mediastinal synovial sarcoma: report of two cases with molecular genetic analysis. Ann Thorac Surg. 2002;73:628-630.
37. Witkin GB, Miettinen M, Rosai J. A biphasic tumor of the mediastinum with features of synovial sarcoma: a report of four cases. Am J Surg Pathol. 1989;13:490-499.
38. Witkin GB, Rosai J. Solitary fibrous tumor of the mediastinum: a report of 14 cases. Am J Surg Pathol. 1989;13:547-557.
39. Zeren H, Moran CA, Suster S, et al. Primary pulmonary sarcomas with features of monophasic synovial sarcoma: a clinicopathological, immunohistochemical, and ultrastructural study of 25 cases. Hum Pathol. 1995;26:474-486.