Spindle cell thymic carcinoma: Clinicopathologic and immunohistochemical study of a distinctive variant of primary thymic epithelial neoplasm

American Journal of Surgical Pathology

Volumn 23, Issue 6, 1999, Pages 691-700

  Suster, Saul ^a,c   Moran, Cesar A ^b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b University of Alabama at Birmingham   (United States)

^c THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Atypical thymoma; Spindle cell thymic carcinoma; Spindle cell thymoma; Thymic carcinoma; Thymic epithelial neoplasms; Thymoma

Indexed keywords

ACTIN; CARCINOEMBRYONIC ANTIGEN; CD34 ANTIGEN; CD5 ANTIGEN; CD99 ANTIGEN; CYTOKERATIN; DESMIN; EPITHELIAL MEMBRANE ANTIGEN; PROTEIN S 100; TUMOR MARKER; VIMENTIN;

ADULT; AGED; ARTICLE; CANCER SURGERY; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL FEATURE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT TRANSFORMATION; MEDIASTINUM TUMOR; SPINDLE CELL CARCINOMA; THYMUS CANCER;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; THYMOMA; THYMUS NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 0033058996     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-199906000-00009     Document Type: Article

References (28)

1. Chen W, Chan CW, Mok CK. Malignant fibrous histiocytoma of the mediastinum. Cancer 1982;50:797-800.
2. Gal AA, Martin SE, Kernen JA, Patterson MJ. Esophageal carcinoma with prominent spindle cells. Cancer 1987;60:2244-50.
3. Hartmann C-A, Roth C, Minck C, Niedobitek G. Thymic carcinoma. Report of five cases and review of the literature. J Cancer Res Clin Oncol 1990;116:69-82.
4. Herczeg E, Kahn LB. Primary thymic carcinoma: an unusual case originating in a lymphocyte-rich thymoma. Virchows Arch A 1986;409:163-9.
5. Kirchner T, Muller-Hermelink HK. New approaches to the diagnosis of thymic epithelial tumors. Prog Surg Pathol 1989;10:167-89.
6. Kuo T-T, Chang J-P, Lin F-J, Wu W-C, Chang C-H. Thymic carcinomas: histopathological varieties and immunohistochemical study. Am J Surg Pathol 1990;14:24-34.
7. Marchevsky AM, Kaneko M. Surgical pathology of the mediastinum, 2nd ed. New York: Raven Press, 1992:274-99.
8. Marino M, Muller-Hermelink HK. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch A 1985;407: 119-49.
9. Matasuno Y, Morozumi N, Hirohashi S, Shimosato Y, Rosai J. Papillary carcinoma of the thymus. Report of four cases of a new microscopic type of thymic carcinoma. Am J Surg Pathol 1998; 22:873-80.
10. Matsui K, Kitagawa M. Lung carcinoma with spindle cell component. Sixteen cases examined by immunohistochemistry. Hum Pathol 1992;23:1289-97.
11. Moran CA, Suster S, Perino G, Kaneko M, Koss MN. Malignant smooth muscle neoplasms presenting as mediastinal soft tissue masses. Clinicopathologic study of 10 cases. Cancer 1994;74: 2251-60.
12. Morinaga S, Sato Y, Shimosato Y, Sinkai T, Tsuchiya R. Multiple thymic squamous cell carcinomas associated with mixed type thymoma. Am J Surg Pathol 1987;11:982-8.
13. Quintanilla-Martinez L, Wilkins EW Jr, Ferry JA, Harris NL. Thymoma - morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases. Hum Pathol 1993;24:958-69.
14. Ro RJ, Chen JL, Lee JS, Sahin AA, Ordoñez NG, Ayala AG. Sarcomatoid carcinoma of the lung: immunohistochemical and ultrastructural study of 14 cases. Cancer 1992;69:376-86.
15. Rosai J, Levine GD. Tumors of the thymus. Atlas of tumor pathology, 2nd edition, fascicle 13. Washington: Armed Forces Institute of Pathology, 1976:34-161.
16. Salyer WR, Eggleston JC. Thymoma: a clinicopathologic study of 65 cases. Cancer 1976;37:229-49.
17. Shimosato Y, Kameya T, Nagaki K, Suemasu K. Squamous cell carcinoma of the thymus: an analysis of eight cases. Am J Surg Pathol 1977;1:109-21.
18. Smith KJ, Skelton HG III, Morgan AM, Barrett TL, Lupton GP. Spindle cell neoplasms coexpressing cytokeratin and vimentin (metaplastic squamous cell carcinoma). J Cutan Pathol 1992;19: 286-93.
19. Snover DC, Levine GD, Rosai J. Thymic carcinoma. Five distinctive histological variants. Am J Surg Pathol 1982;6:451-70.
20. Suarez-Vilela D, Salas-Valien JS, Gonzalez-Moran MA, Izquierdo-Garcia F, Riera-Velasco JR. Thymic carcinosarcoma associated with a spindle cell thymoma: an immunohistochemical study. Histopathology 1992;21:263-8.
21. Suster S, Moran CA, Koss MN. Primary rhabdomyosarcomas of the anterior mediastinum. Report of 4 cases unassociated with germ cell, teratomatous or thymic carcinomatous components. Hum Pathol 1994;25:349-56.
22. Suster S, Moran CA, Thymoma, atypical thymoma, and thymic carcinoma. A novel conceptual approach to the classification of primary thymic epithelial neoplasms. Am J Clin Pathol, in press.
23. Suster S, Moran CA. Thymic carcinoma: spectrum of differentiation and histologic types. Pathology 1998;30:111-22.
24. Suster S, Moran CA. Primary thymic epithelial neoplasms with combined features of thymoma and thymic carcinoma. A clinicopathologic study of 22 cases. Am J Surg Pathol 1996;20:1469-80.
25. Suster S, Rosai J, Thymic carcinoma. A clinicopathologic study of 60 cases. Cancer 1991;67:1025-32.
26. Walker AN, Nilles SE, Fechner RE. Thymomas and thymic carcinomas. Semin Diagn Pathol 1990;7:250-65.
27. Wick MR, Weiland LH, Scheithauer BW, Bernatz PE. Primary thymic carcinomas. Am J Surg Pathol 1982;6:613-30.
28. Witkin GB, Rosai J. Solitary fibrous tumor of the mediastinum. A report of 14 cases. Am J Surg Pathol 1989;13:547-57.