Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease

Particle and Fibre Toxicology

Volumn 9, Issue , 2012, Pages

  Löndahl, Jakob ^a   Swietlicki, Erik ^a   Rissler, Jenny ^a   Bengtsson, Agneta ^a   Boman, Christoffer ^b   Blomberg, Anders ^b   Sandström, Thomas ^b  

^a LUND UNIVERSITY   (Sweden)

^b UMEÅ UNIVERSITY   (Sweden)

Author keywords

Aerosol; Agglomerate; Air pollution; COPD; Diesel exhaust; Health effects; Lung deposition; Nanoparticles; Toxicity

Indexed keywords

ADULT; AGED; ARTICLE; BIOACCUMULATION; BREATHING PATTERN; CAR DRIVING; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COMBUSTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; EXHAUST GAS; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; LUNG FUNCTION; MALE; MEASUREMENT; PARTICLE SIZE; PRIORITY JOURNAL; PROBABILITY; RESPIRATORY TRACT DEPOSITION; RESPIRATORY TRACT PARAMETERS;

AEROSOLS; AGED; ATMOSPHERE EXPOSURE CHAMBERS; FEMALE; HUMANS; LUNG; MALE; MIDDLE AGED; PARTICLE SIZE; PARTICULATE MATTER; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY VENTILATION; RESPIRATORY MUCOSA; SEVERITY OF ILLNESS INDEX; TISSUE DISTRIBUTION; VEHICLE EMISSIONS;

EID: 84864229214     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-9-30     Document Type: Article

References (26)

1. Global surveillance, prevention and control of chronic respiratory diseases: A comprehensive approach 2007, WHO Library Cataloguing-in-Publication Data, Geneva, Switzerland, Bousquet J, Khaltaev N, ISBN 978 92 4 15634 8.
2. World Health Organization The global burden of disease: 2004 update 2008, World Health Organization, Geneva, Switzerland, World Health Organization.
3. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJL. Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 2006, 367:1747-1757. 10.1016/S0140-6736(06)68770-9, 16731270.
4. Anderson PJ, Wilson JD, Hiller FC. Respiratory-Tract Deposition of Ultrafine Particles in Subjects with Obstructive Or Restrictive Lung-Disease. Chest 1990, 97:1115-1120. 10.1378/chest.97.5.1115, 2331906.
5. Brown JS, Zeman KL, Bennett WD. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 2002, 166:1240-1247. 10.1164/rccm.200205-399OC, 12403694.
6. Möller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, Haussinger K, Kreyling WG. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 2008, 177:426-432.
7. Barath S, Mills NL, Lundback M, Tornqvist H, Lucking AJ, Langrish JP, Soderberg S, Boman C, Westerholm R, Londahl J, et al. Impaired vascular function after exposure to diesel exhaust generated at urban transient running conditions. Part Fibre Toxicol 2010, 7:19. 10.1186/1743-8977-7-19, 2918524, 20653945.
8. Mills NL, Tornqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, et al. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 2005, 112:3930-3936. 10.1161/CIRCULATIONAHA.105.588962, 16365212.
9. Mills NL, Tornqvist H, Gonzalez MC, Vink E, Robinson SD, Soderberg S, Boon NA, Donaldson K, Sandstrom T, Blomberg A, et al. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 2007, 357:1075-1082. 10.1056/NEJMoa066314, 17855668.
10. Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate ST, Frew A. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med 1999, 159:702-709.
11. Rissler J, Swietlicki E, Bengtsson A, Boman C, Pagels J, Sandström T, Blomberg A, Löndahl J. Experimental determination of deposition of diesel exhaust particles in the human respiratory tract. J Aerosol Sci 2012, 48:18-33.
12. Hart JE, Laden F, Eisen EA, Smith TJ, Garshick E. Chronic obstructive pulmonary disease mortality in railroad workers. Occup Environ Med 2009, 66:221-226. 2658724, 19039098.
13. Tobin MJ, Chadha TS, Jenouri G, Birch SJ, Gazeroglu HB, Sackner MA. Breathing Patterns .1. Normal Subjects. Chest 1983, 84:202-205. 10.1378/chest.84.2.202, 6872603.
14. Tobin MJ, Chadha TS, Jenouri G, Birch SJ, Gazeroglu HB, Sackner MA. Breathing Patterns .2. Diseased Subjects. Chest 1983, 84:286-294. 10.1378/chest.84.3.286, 6884104.
15. Löndahl J, Pagels J, Swietlicki E, Zhou JC, Ketzel M, Massling A, Bohgard M. A set-up for field studies of respiratory tract deposition of fine and ultrafine particles in humans. J Aerosol Sci 2006, 37:1152-1163.
16. Löndahl J, Massling A, Pagels J, Swietlicki E, Vaclavik E, Loft S. Size-resolved respiratory-tract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise. Inhal Toxicol 2007, 19:109-116. 10.1080/08958370601051677, 17169858.
17. Löndahl J, Pagels J, Boman C, Swietlicki E, Massling A, Rissler J, Blomberg A, Bohgard M, Sandstrom T. Deposition of biomass combustion aerosol particles in the human respiratory tract. Inhal Toxicol 2008, 20:923-933. 10.1080/08958370802087124, 18668412.
18. Löndahl J, Massling A, Swietlicki E, Brauner EV, Ketzel M, Pagels J, Loft S. Experimentally Determined Human Respiratory Tract Deposition of Airborne Particles at a Busy Street. Environ Sci Technol 2009, 43:4659-4664. 10.1021/es803029b, 19673248.
19. Morawska L, Hofmann W, Hitchins-Loveday J, Swanson C, Mengersen K. Experimental study of the deposition of combustion aerosols in the human respiratory tract. J Aerosol Sci 2005, 36:939-957.
20. Scheckman JH, Mcmurry PH. Deposition of silica agglomerates in cast of human lung airways: Enhancement relative to spheres of equal mobility and aerodynamic diameter. J Aerosol Sci 2011, 42:508-516.
21. O'Donnell MD, O'Connor CM, FitzGerald MX, Lungarella G, Cavarra E, Martorana PA. Ultrastructure of lung elastin and collagen in mouse models of spontaneous emphysema. Matrix Biol 1999, 18:357-360. 10.1016/S0945-053X(99)00031-1, 10517182.
22. Beinert T, Brand P, Behr J, Vogelmeier C, Heyder J. Peripheral Airspace Dimensions in Patients with Copd. Chest 1995, 108:998-1003. 10.1378/chest.108.4.998, 7555176.
23. Bennett WD, Smaldone GC. Use of Aerosols to Estimate Mean Air-Space Size in Chronic Obstructive Pulmonary-Disease. J Appl Physiol 1988, 64:1554-1560.
24. Kim CS, Lewars GA, Sackner MA. Measurement of Total Lung Aerosol Deposition As An Index of Lung Abnormality. J Appl Physiol 1988, 64:1527-1536.
25. GOLD executive committee Pocket guide to COPD diagnosis,management and prevention. A guide for health care professionals 2011, Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD), , http://www.goldcopd.org/, GOLD executive committee.
26. Gebhart J, Schiller CF, Egan MJ, Nixon W. On the Relationship Between Experimental-Data for Total Deposition and Model-Calculations .1. Effect of Instrumental Dead Space. J Aerosol Sci 1989, 20:141-147.