Red blood cell alterations in systemic sclerosis: A pilot study

Cellular Physiology and Biochemistry

Volumn 30, Issue 2, 2012, Pages 418-427

  Giovannetti, Antonello ^a   Gambardella, Lucrezia ^b   Pietraforte, Donatella ^b   Rosato, Edoardo ^a   Giammarioli, Anna Maria ^b   Salsano, Felice ^a   Malorni, Walter ^b,c   Straface, Elisabetta ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c San Raffaele Institute Sulmona   (Italy)

Author keywords

Erythrocytes; Oxidative stress; Scleroderma

Indexed keywords

CD47 ANTIGEN; ERYTHROCYTE BAND 3 PROTEIN; GLYCOPHORIN A; PHOSPHATIDYLSERINE; REACTIVE OXYGEN METABOLITE; THIOL;

ADULT; ARTICLE; CAPILLAROSCOPY; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSE SCLERODERMA; DISEASE SEVERITY; ERYTHROCYTE LIFESPAN; ERYTHROCYTE PARAMETERS; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIMITED SCLERODERMA; MALE; OXIDATION REDUCTION STATE; PILOT STUDY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; SYSTEMIC SCLEROSIS;

EID: 84864210950     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000339035     Document Type: Article

References (40)

1. Clements PJ: Systemic sclerosis (scleroderma) and related disorders: clinical aspects. Bailleres Best Pract Res Clin Rheum 2000;14:1-16.
2. Merkel PA, Herlyn K, Martin RW, Anderson JJ, Mayes MD, Bell P, Korn JH, Simms RW, Csuka ME, Medsger TA Jr, Rothfield NF, Ellman MH, Collier DH, Weinstein A, Furst DE, Jimenez SA, White B, Seibold JR, Wigley FM; Scleroderma Clinical Trials Consortium: Measuring disease activity and functional status in patients with scleroderma and Raynaud's phenomenon. Arthritis Rheum 2002;46:2410-2420.
3. LeRoy EC, Black C, Fleischmajer R, Jablonska S, Krieg T, Medsger TA Jr, Rowell N, Wollheim F: Scleroderma (systemic sclerosis): classification, subsets and pathogenesis. J Rheumatol 1988;15:202-205.
4. Hachulla E, Launay D, Mouthon L, Sitbon O, Berezne A, Guillevin L, Hatron PY, Simonneau G, Clerson P, Humbert M: French PAH-SSc Network Is pulmonary arterial hypertension really a late complication of systemic sclerosis? Chest 2009;136:1211-1219.
5. Krieg T, Takehara K: Skin disease: a cardinal feature of systemic sclerosis. Rheumatology 2009;48:14-18.
6. Yamamoto T: Autoimmune mechanisms of scleroderma and a role of oxidative stress. Self Nonself 2011;2:4-10.
7. Sambo P, Jannino L, Candela M, Salvi A, Donini M, Dusi S: Monocytes of patients with systemic sclerosis (scleroderma) spontaneously release in vitro increased amounts of superoxide anion. J Invest Dermatol 1999;112:78-84.
8. Esterbauer H, Dieber-Rothender M, Maeg G, Striegl G, Jurges G: Biochemical structural and functional properties of oxidised low-density lipoprotein. Chem Res Toxicol 1990;3:77-92.
9. Pratico" D: Antioxidants and endothelium protection. Atherosclerosis 2005;181:215-224.
10. YarnoldJ, Brotons MC: Pathogenetic mechanisms in radiation fibrosis. Radiother Oncol 2010;97:149-161.
11. Jia Y, Wood F, Menu P, Faivre B, Caron A, Alayash AI: Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran. Biochim Biophys Acta 2004;1672:164-173.
12. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO 3rd, Gladwin MT: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003;9:1498-1505.
13. Minetti M, Agati L, Malorni W: The microenvironment can shift erythrocytes from a friendly to a harmful behavior: pathogenetic implications for vascular diseases. Cardiovasc Res 2007;75:21-28.
14. Baskurt OK, Meiselman HJ: Red blood cell "aggregability". Clin Hemorheol Microcirc 2009;43:353-354.
15. Yedgar S, Kaul DK, Barshtein G: RBC adhesion to vascular endothelial cells: more potent than RBC aggregation in inducing circulatory disorders. Microcirculation 2008;15:581-583.
16. Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee Arthritis Rheum. Preliminary criteria for the classification of systemic sclerosis (scleroderma). 1980;23:581-590.
17. Clements P, Lachenbruch P, Siebold J, White B, Weiner S, Martin R, Weinstein A, Weisman M, Mayes M, Collier D: Inter and intraobserver variability of total skin thickness score (modified Rodnan TSS) in systemic sclerosis. J Rheumatol 1995;22:1281-1285.
18. Valentini G, DAngelo S, Delia Rossa A, Bencivelli W, Bombardieri S: European Scleroderma Study Group to define disease activity criteria for systemic sclerosis. IV. Assessment of skin thickening by modified Rodnan skin score. Ann Rheum Dis 2003;62:904-905.
19. Valentini G, Delia Rossa A, Bombardieri S, Bencivelli W, Silman AJ, DAngelo S, Cerinic MM, Belch JF, Black CM, Bruhlmann P, Czirjak L, De Luca A, Drosos AA, Ferri C, Gabrielli A, Giacomelli R, Hayem G, Inane M, McHugh NJ, Nielsen H, Rosada M, Scorza R, Stork J, Sysa A, van den Hoogen FH, Vlachoyiannopoulos PJ: European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes. Ann Rheum Dis 2001;60:592-598.
20. Medsger TA Jr, Silman AJ, Steen VD, Black CM, Akesson A, Bacon PA, Harris CA, Jablonska S, Jayson MI, Jimenez SA, Krieg T, Leroy EC, Maddison PJ, Russell ML, Schachter RK, Wollheim FA, Zacharaie H: A disease severity scale for systemic sclerosis: development and testing. J Rheumatol 1999;26:2159-2167.
21. Cutolo M, Sulli A, Pizzorni C, Accardo S: Nailfold videocapillaroscopy assessment of microvascular damage in systemic sclerosis. J Rheumatol 2000;27:155-160.
22. Caprari P, Bozzi A, Malorni W, Bottini A, Iosi F, Santini MT, Salvati AM: Junctional sites of erythrocyte skeletal proteins are specific targets of tert-butylhydroperoxide oxidative damage. Chem Biol Interact 1995;943:243-258.
23. Matarrese P, Straface E, Pietraforte D, Gambardella L, Vona R, Maccaglia A: Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases. FASEB J 2005;19:416-418.
24. Khandelwal S, van Rooijen N, Saxena RK: Reduced expression of CD47 during murine red blood cell (RBC) senescence and its role in RBC clearance from the circulation. Transfusion 2007;47:1725-1732.
25. Mandal D, Mazumder A, Das P, Kundu M, Basu J: Fas-, caspase 8-, and caspase 3-dependent signaling regulates the activity of the aminophospholipid translocase and phosphatidylserine externalization in human erythrocytes. J Biol Chem 2005;280:39460-39467.
26. Manetti M, Guiducci S, Ibba-Manneschi L, Matucci-Cerinic M: Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis. J Cell Mol Med 2010;14:1241-1254.
27. Konttinen YT, Mackiewicz Z, Ruuttila P, Ceponis A, Sukura A, Povilenaite D, Hukkanen M, Virtanen I: Vascular damage and lack of angiogenesis in systemic sclerosis skin. Clin Rheumatol 2003;22:196-202.
28. Forstermann U: Nitric oxide and oxidative stress in vascular disease. Pflugers Arch 2010;459:923-939.
29. Minetti M, Malorni W: Redox control of red blood cell biology: the red blood cell as a target and source of prooxidant species. Antioxid Redox Signal 2006;8:1165-1169.
30. Buehler PW, Alayash AI: Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature. Antioxid Redox Signal 2004;6:1000-1010.
31. Oldenborg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP: Role of CD47 as a marker of self on red blood cells. Science 2000;288:2051-2054.
32. Oldenborg PA: Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma 2004;45:1319-1327.
33. Dugas V, Beauchamp C, Chabot-Roy G, Hillhouse EE, Lesage S: Implication of the CD47 pathway in autoimmune diabetes. J Autoimmun 2010;35:23-32.
34. Yedgar S, Koshkaryev A, Barshtein G: The red blood cell in vascular occlusion. Pathophysiol Haemost Thromb 2002;32:263-268.
35. Arnout J: The pathogenesis of the antiphospholipid syndrome: a hypothesis based on parallelisms with heparin-induced thrombocytopenia. Thromb Haemost 1996;75:536-541.
36. Giovannetti A, Rosato E, Renzi C, Maselli A, Gambardella L, Giammarioli AM, Palange P, Paoletti P, Pisarri S, Salsano F, Malorni W, Pierdominici M: Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis. Correlations with disease severity and phenotypes. Clin Immunol 2010;137:122-133.
37. Lucantoni G, Pietraforte D, Matarrese P, Gambardella L, Metere A, Paone G, Bianchi EL, Straface E: The red blood cell as a biosensor for monitoring oxidative imbalance in chronic obstructive pulmonary disease: an ex vivo and in vitro study. Antioxid Redox Signal. 2006;8:1171-1182.
38. Rosato E, Borghese F, Pisarri S, Salsano F: The treatment with N-acetylcysteine of Raynaud's phenomenon and ischemic ulcers therapy in sclerodermic patients: a prospective observational study of 50 patients. Clin Rheumatol 2009;28:1379-1384.
39. Del Papa N, Quirici N, Scavullo C, Gianelli U, Corti L, Vitali C, Ferri C, Giuggioli D, Manfredi A, Maglione W, Onida F, Colaci M, Bosari S, Lambertenghi Deliliers G: Antiendothelial cell antibodies induce apoptosis of bone marrow endothelial progenitors in systemic sclerosis. J Rheumatol 2010;37:2053-2063.
40. Lang F, Lang KS, Lang PA, Huber SM, Wieder T: Mechanisms and significance of eryptosis. Antioxid Redox Signal 2006;8:1183-1192.