Comparable polyfunctionality of ectromelia virus- and vaccinia virus-specific murine T Cells despite markedly different in vivo replication and pathogenicity

Journal of Virology

Volumn 86, Issue 13, 2012, Pages 7298-7309

  Hersperger, Adam R ^a   Siciliano, Nicholas A ^a   Eisenlohr, Laurence C ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SPECIFICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOLYSIS; DEGRANULATION; ECTROMELIA VIRUS; FEMALE; FLOW CYTOMETRY; IMMUNOREACTIVITY; IN VIVO STUDY; MEMORY T LYMPHOCYTE; MOUSEPOX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION; TH1 CELL; UPREGULATION; VACCINIA VIRUS; VIRUS CELL INTERACTION; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; CELL DEGRANULATION; CYTOKINES; CYTOTOXICITY TESTS, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; ECTROMELIA VIRUS; ECTROMELIA, INFECTIOUS; FEMALE; FLOW CYTOMETRY; GRANZYMES; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; VACCINIA; VACCINIA VIRUS;

ECTROMELIA VIRUS; MURINAE; MUS; ORTHOPOXVIRUS; POXVIRIDAE; VACCINIA VIRUS; VARIOLA VIRUS;

EID: 84864148749     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00038-12     Document Type: Article

References (55)

1. Abrahao JS, et al. 2009. One more piece in the VACV ecological puzzle: could peridomestic rodents be the link between wildlife and bovine vaccinia outbreaks in Brazil? PLoS One 4:e7428. doi:10.1371/journal.pone.0007428.
2. Betts MR, et al. 2003. Sensitive and viable identification of antigenspecific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Methods 281:65-78.
3. Betts MR, et al. 2006. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107:4781- 4789.
4. Bhatt PN, Jacoby RO. 1987. Mousepox in inbred mice innately resistant or susceptible to lethal infection with ectromelia virus. I. Clinical responses. Lab. Anim. Sci. 37:11-15.
5. Blanden RV. 1970. Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. J. Exp. Med. 132:1035-1054.
6. Blanden RV. 1971. Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. J. Exp. Med. 133:1074 -1089.
7. Breman JG, Henderson DA. 2002. Diagnosis and management of smallpox. N. Engl. J. Med. 346:1300 -1308.
8. Burnet FM. 1945. An unsuspected relationship between the viruses of vaccinia and infectious ectromelia of mice. Nature 155:543.
9. Burnet FM, Boake WC. 1946. The relationship between the virus of infectious ectromelia of mice and vaccinia virus. J. Immunol. 53:1-13.
10. Chaudhri G, Panchanathan V, Bluethmann H, Karupiah G. 2006. Obligatory requirement for antibody in recovery from a primary poxvirus infection. J. Virol. 80:6339-6344.
11. Chaudhri G, et al. 2004. Polarized type 1 cytokine response and cellmediated immunity determine genetic resistance to mousepox. Proc. Natl. Acad. Sci. U. S. A. 101:9057-9062.
12. Darrah PA, et al. 2007. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat. Med. 13: 843-850.
13. Duvall MG, et al. 2008. Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur. J. Immunol. 38:350 -363.
14. Esteban DJ, Buller RM. 2005. Ectromelia virus: the causative agent of mousepox. J. Gen. Virol. 86:2645-2659.
15. Fang M, Sigal L. 2010. Studying NK cell responses to ectromelia virus infections in mice. Methods Mol. Biol. 612:411- 428.
16. Fang M, Sigal LJ. 2005. Antibodies and CD8+ T cells are complementary and essential for natural resistance to a highly lethal cytopathic virus. J. Immunol. 175:6829-6836.
17. Fang M, Sigal LJ. 2006. Direct CD28 costimulation is required for CD8+ T cell-mediated resistance to an acute viral disease in a natural host. J. Immunol. 177:8027- 8036.
18. Fenner F. 2006. Classic paper: Fenner on the exanthemata. Rev. Med. Virol. 16:353-363.
19. Fenner F. 1949. Mouse-pox; infectious ectromelia of mice; a review. J. Immunol. 63:341-373.
20. Fenner F. 1947. Studies in infectious ectromelia in mice; natural transmission; the portal of entry of the virus. Aust. J. Exp. Biol. Med. Sci. 25:275-282.
21. Fenner F. 1947. Studies in infectious ectromelia of mice; immunization of mice against ectromelia with living vaccinia virus. Aust. J. Exp. Biol. Med. Sci. 25:257-274.
22. Fenner F. 1948. The pathogenesis of the acute exanthems; an interpretation based on experimental investigations with mousepox; infectious ectromelia of mice. Lancet ii:915-920.
23. Garcia-Arriaza J, Najera JL, Gomez CE, Sorzano CO, Esteban M. 2010. Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions. PLoS One 5:e12395. doi:10.1371/journal.pone. 0012395.
24. Gomez CE, et al. 2011. The HIV/AIDS vaccine candidate MVA-B administered as a single immunogen in humans triggers robust, polyfunctional, and selective effector memory T cell responses to HIV-1 antigens. J. Virol. 85:11468 -11478.
25. Gubser C, Hue S, Kellam P, Smith GL. 2004. Poxvirus genomes: a phylogenetic analysis. J. Gen. Virol. 85:105-117.
26. Harari A, et al. 2008. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses. J. Exp. Med. 205:63-77.
27. Hersperger AR, et al. 2010. Perforin expression directly ex vivo by HIVspecific CD8 T-cells is a correlate of HIV elite control. PLoS Pathog. 6:e1000917. doi:10.1371/journal.ppat.1000917.
28. Hickman HD, et al. 2008. Direct priming of antiviral CD8+T cells in the peripheral interfollicular region of lymph nodes. Nat. Immunol. 9:155- 165.
29. Karupiah G, Buller RM, Van Rooijen N, Duarte CJ, Chen J. 1996. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. J. Virol. 70:8301- 8309.
30. Kees U, Blanden RV. 1976. A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection. J. Exp. Med. 143: 450-455.
31. Makedonas G, et al. 2009. Rapid up-regulation and granule-independent transport of perforin to the immunological synapse define a novel mechanism of antigen-specific CD8+ T cell cytotoxic activity. J. Immunol. 182:5560 -5569.
32. Makedonas G, et al. 2010. Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells. PLoS Pathog. 6:e1000798. doi:10.1371/journal.ppat.1000798.
33. Marchal J. 1930. Infectious ectromelia: a hitherto undescribed virus disease of mice. J. Pathol. Bacteriol. 33:713-728.
34. Moutaftsi M, et al. 2007. Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+T cell responses. J. Immunol. 178:6814-6820.
35. Moutaftsi M, et al. 2006. A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat. Biotechnol. 24:817- 819.
36. Mullbacher A. 2003. Cell-mediated cytotoxicity in recovery from poxvirus infections. Rev. Med. Virol. 13:223-232.
37. Mullbacher A, et al. 1996. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc. Natl. Acad. Sci. U. S. A. 93:5783-5787.
38. Mullbacher A, Hla RT, Museteanu C, Simon MM. 1999. Perforin is essential for control of ectromelia virus but not related poxviruses in mice. J. Virol. 73:1665-1667.
39. Mullbacher A, et al. 1999. Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. U. S. A. 96:13950 -13955.
40. Panchanathan V, Chaudhri G, Karupiah G. 2008. Correlates of protective immunity in poxvirus infection: where does antibody stand? Immunol. Cell Biol. 86:80-86.
41. Panchanathan V, Chaudhri G, Karupiah G. 2006. Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function. J. Virol. 80:6333- 6338.
42. Perfetto SP, et al. 2006. Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry. J. Immunol. Methods 313:199 -208.
43. Pipkin ME, Lieberman J. 2007. Delivering the kiss of death: progress on understanding how perforin works. Curr. Opin. Immunol. 19:301-308.
44. Precopio ML, et al. 2007. Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J. Exp. Med. 204:1405-1416.
45. Ruby J, Bluethmann H, Peschon JJ. 1997. Antiviral activity of tumor necrosis factor (TNF) is mediated via p55 and p75 TNF receptors. J. Exp. Med. 186:1591-1596.
46. Russell JH, Ley TJ. 2002. Lymphocyte-mediated cytotoxicity. Annu. Rev. Immunol. 20:323-370.
47. Seder RA, Darrah PA, Roederer M. 2008. T-cell quality in memory and protection: implications for vaccine design. Nat. Rev. Immunol. 8:247- 258.
48. Siciliano NA, Skinner JA, Yuk MH. 2006. Bordetella bronchiseptica modulates macrophage phenotype leading to the inhibition of CD4+ T cell proliferation and the initiation of a Th17 immune response. J. Immunol. 177:7131-7138.
49. Silva-Fernandes AT, et al. 2009. Natural human infections with vaccinia virus during bovine vaccinia outbreaks. J. Clin. Virol. 44:308 -313.
50. Spriggs MK, et al. 1992. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. U. S. A. 89:6070-6074.
51. Symons JA, Tscharke DC, Price N, Smith GL. 2002. A study of the vaccinia virus interferon-gamma receptor and its contribution to virus virulence. J. Gen. Virol. 83:1953-1964.
52. Tscharke DC, et al. 2005. Identification of poxvirus CD8+ T cell determinants to enable rational design and characterization of smallpox vaccines. J. Exp. Med. 201:95-104.
53. Tscharke DC, Smith GL. 1999. A model for vaccinia virus pathogenesis and immunity based on intradermal injection of mouse ear pinnae. J. Gen. Virol. 80(Pt 10):2751-2755.
54. Wherry EJ, et al. 2003. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4:225-234.
55. Xu RH, Fang M, Klein-Szanto A, Sigal LJ. 2007. Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection. Proc. Natl. Acad. Sci. U. S. A. 104:10992-10997.