Adverse drug events in high risk older outpatients

Journal of the American Geriatrics Society

Volumn 45, Issue 8, 1997, Pages 945-948

  Hanlon, Joseph T ^a,b,c   Schmader, Kenneth E ^a,b   Koronkowski, Michael J ^c,e   Weinberger, Morris ^d   Landsman, Pamela B ^b,f   Samsa, Gregory P ^a,b   Lewis, Ingrid K ^a,b,c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d INDIANA UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^f MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMIODARONE; ATENOLOL; CARBAMAZEPINE; CARDIOVASCULAR AGENT; CENTRAL NERVOUS SYSTEM AGENTS; COLESTIPOL; COTRIMOXAZOLE; GASTROINTESTINAL AGENT; HORMONE; HYDROCHLOROTHIAZIDE; IMIPRAMINE; PIROXICAM; RESPIRATORY TRACT AGENT; THEOPHYLLINE; WARFARIN;

ADVERSE DRUG REACTION; AGED; ARTICLE; BLOOD TOXICITY; CARDIOTOXICITY; DRUG THERAPY; ELDERLY CARE; EYE TOXICITY; GASTROINTESTINAL SYMPTOM; HEALTH CARE UTILIZATION; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; NEUROTOXICITY; PREVALENCE; SELF REPORT; SKIN TOXICITY;

EID: 0030840997     PISSN: 00028614     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1532-5415.1997.tb02964.x     Document Type: Article

References (40)

1. Naranjo CA, Shear NH, Lanctot KL. Advances in the diagnosis of adverse drug reactions. J Clin Pharmacol 1992;32:897-904.
2. Johnson JA, Bootman JL. Drug-related morbidity and mortality: A cost of illness model. Arch Intern Med 1995;155:1949-1956.
3. Burke LB, Jolson HM, Goetsch RA et al. Geriatric drug use and adverse event reporting in 1990. Ann Rev Gerontol Geriatr 1992;12:1-28.
4. Hanlon JT, Schmader KE, Lewis IK. Adverse drug reactions. In: Delafuente JC, Stewart RB, eds. Therapeutics in the Elderly, 2nd Ed. Cincinnati: Harvey Whitney Books, 1995, pp 212-227.
5. Nolan L, O'Malley K. Prescribing for the elderly, Part I: Sensitivity of the elderly to adverse drug reactions. J Am Geriatr Soc 1988;36:142-140.
6. Walker J, Wynne H. Review: The frequency and severity of adverse drug reactions in elderly people. Age Ageing 1994;23:255-259.
7. General Accounting Office. Prescription drugs and the elderly: Many still receive potentially harmful drugs despite recent improvements. GAO/HEHS-95-152:1-30.
8. Bates DW, Cullen DJ, Laird N et al. Incidence of adverse drug events and potential adverse drug events: implications for prevention. JAMA 1995;274:29-34.
9. Atkin PA, Shenfield GM. Medication-related adverse reactions and the elderly: A literature review. Adverse Drug React Toxicol Rev 1995;14:175-191.
10. Fink A, Siu AL, Brook RH et al. Assuring the quality of health care for older persons. JAMA 1987;258:1905-1908.
11. Stewart RB, Cooper JW. Polypharmacy in the aged: Practical solutions. Drugs Aging 1994;4:449-461.
12. Montamat SC, Cusack B. Overcoming problems with polypharmacy and drug misuse. Clin Geriatr Med 1992;8:143-158.
13. Healthy People 2000. National health promotion and disease prevention objectives. U.S. Department of Health and Human Services. Washington, DC: GPO, 1991.
14. Schneider JK, Mion LC, Frengley JD. Adverse drug reactions in an elderly outpatient population. Am J Hosp Pharm 1992;49:90-96.
15. Chrischilles EA, Segar ET, Wallace RB. Self-reported adverse drug reactions and related resource use: A study of community-dwelling persons 65 years of age and older. Ann Intern Med 1992;117:634-640.
16. Cartwright A, Smith C, eds. Prescribed medicines taken and kept by the elderly people. In: Elderly People, Their Medicines, and Their Doctors. London:Routledge, 1988, pp 30-33.
17. Klein LE, German PS, Levine DM et al. Medication problems among outpatients: A study with emphasis on the elderly. Arch Intern Med 1984;144:1185-1188.
18. Hutchinson TA, Flegel KM, Kramer MS et al. Frequency, severity, and risk factors for adverse drug reactions in adults out-patients: A prospective study. J Chronic Dis 1986;39:533-542.
19. Hanlon JT, Weinberger M, Samsa GP et al. A randomized controlled trial of a clinical pharmacist intervention with elderly outpatients with polypharmacy. Am J Med 1996;100:428-437.
20. Kahn RL, Goldfarb AI, Pollack M, Peck A brief objective measures for the determination of mental status in the aged. Am J Psychiatry 1960;117:326-328.
21. Ware JE, Sherbourne CD. The MOS 36-item short-form health survey (SF-36).conceptual framework and item selection. Med Care 1992;30:473-483.
22. McEvoy GK, ed. AHFS Drug Information 1992. Bethesda: American Society of Hospital Pharmacists, 1992.
23. Goodman LS, Gilman A, eds. The Pharmacological Basis of Therapeutics. 8th Ed. New York: Pergamon, 1990.
24. Rawlins MD. Adverse reactions to drugs. Br Med J 1981;282:974-976.
25. Veterans Affairs Medication Classification System. In: United States Pharmacopeia Dispensing Information (USP DI), 10th Ed., Appendix VI. Rockville, MD:USPDI, 1990, pp 2925-2960.
26. U.S. Department of Health and Human Services. ICD-9-CM, 4th Ed. Alexandria, VA: St. Anthony's Publishing, 1991.
27. Col N, Fanale JE, Kronholm P. The role of medication noncompliance and adverse drug reactions in hospitalizations in the elderly. Arch Intern Med 1990;150:841-845.
28. Colt HG, Shapiro AP. Drug-induced illness as a cause for admission to a community hospital. J Am Geriatr Soc 1989;37:323-326.
29. Gerety M, Cornell JE, Plichta D, Eimer M. Adverse events related to drugs and drug withdrawal in nursing home residents. J Am Geriatr Soc 1993;41:1326-1332.
30. Grymonpre RE, Mitenko PA, Sitar DS et al. Drug-associated hospital admissions in older medical patients. J Am Geriatr Soc 1988;36:1092-1098.
31. Hallus J, Gram LF, Grodum E et al. Drug-related admissions to medical wards: a population based survey. Br J Clin Pharmacol 1992;33:61-68.
32. Levy M, Kewitz H, Altwein W et al. Hospital admissions due to adverse drug reactions: A comparative study from Jerusalem and Berlin. Eur J Clin Pharmacol 1980;17:25-31.
33. Smucker WD, Kontak JR. Adverse drug reactions causing hospital admission in an elderly population: Experience with a decision algorithm. J Am Board Fam Pract 1990;3:105-109.
34. Williamson J, Chopin JM. Adverse reactions to prescribed drugs in the elderly: A multicenter investigation. Age Ageing 1980;9:73-80.
35. Carbonin P, Pahor M, Bernabei R, Sgadari A. Is age an independent risk factor for adverse drug reactions in hospitalized medical patients? J Am Geriatr Soc 1991;39:1093-1099.
36. Gurwitz JH, Avorn J. The ambiguous relation between aging and adverse drug reactions. Ann Intern Med 1991;114:956-966.
37. Rosner B. Fundamentals of Biostatistics, 3rd Ed. Boston: PWS-Kent Co., 1990.
38. SAS Institute,. SAS/STAT User's Guide. Cary, NC: SAS Institute, 1993.
39. Schmader K, Hanlon JT, Weinberger M et al. Appropriateness of medication prescribing in ambulatory elderly patients. J Am Geriatr Soc 1994;42:1241-1247.
40. Helling DK, Lemke LH, Semla TP et al. Medication use characteristics in the elderly: The Iowa 65+ Rural Health Study. J Am Geriatr Soc 1987;35:4-12.