Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

Journal of Bone and Mineral Research

Volumn 27, Issue 8, 2012, Pages 1773-1783

  Olivares Navarrete, Rene ^a   Raines, Andrew L ^a,b   Hyzy, Sharon L ^a   Park, Jung Hwa ^a   Hutton, Daphne L ^a   Cochran, David L ^c   Boyan, Barbara D ^a   Schwartz, Zvi ^a,c  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b Saint Joseph's Translational Research Institute   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

1,25 DIHYDROXYVITAMIN D3; AGE; MICROSTRUCTURED TITANIUM; OSSEOINTEGRATION; OSTEOBLASTS

Indexed keywords

ALPHA1 INTEGRIN; BETA1 INTEGRIN; CALCIFEDIOL; INTEGRIN RECEPTOR; OSTEOCALCIN; OSTEOPROTEGERIN; TITANIUM; TRANSFORMING GROWTH FACTOR BETA1; VASCULOTROPIN A;

AGING; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; CELL COUNT; CELL MATURATION; CONTROLLED STUDY; HISTOLOGY; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; METAL IMPLANTATION; NONHUMAN; OSSIFICATION; OSTEOBLAST; PROTEIN EXPRESSION; RAT; VASCULARIZATION;

AGING; ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMPLANTS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; TITANIUM;

EID: 84864124423     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1628     Document Type: Article

References (38)

1. Ratner BDHA, Schoen FJ, Lemons JE., Biomaterials science: an introduction to materials in medicine. 2nd ed. San Diego: Elsevier Academic Press; 2004.
2. Ellingsen JE., A study on the mechanism of protein adsorption to TiO2. Biomaterials. 1991; 12 (6): 593-6.
3. Kieswetter K, Schwartz Z, Dean DD, Boyan BD., The role of implant surface characteristics in the healing of bone. Crit Rev Oral Biol Med. 1996; 7 (4): 329-45.
4. Goto T, Yoshinari M, Kobayashi S, Tanaka T., The initial attachment and subsequent behavior of osteoblastic cells and oral epithelial cells on titanium. Biomed Mater Eng. 2004; 14 (4): 537-44.
5. Martin JY, Schwartz Z, Hummert TW, Schraub DM, Simpson J, Lankford J Jr, Dean DD, Cochran DL, Boyan BD., Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). J Biomed Mater Res. 1995; 29 (3): 389-401.
6. Olivares-Navarrete R, Raz P, Zhao G, Chen J, Wieland M, Cochran DL, Chaudhri RA, Ornoy A, Boyan BD, Schwartz Z., Integrin alpha2beta1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates. Proc Natl Acad Sci U S A. 2008; 105 (41): 15767-72.
7. Olivares-Navarrete R, Hyzy SL, Hutton DL, Erdman CP, Wieland M, Boyan BD, Schwartz Z., Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage. Biomaterials. 2010; 31 (10): 2728-35.
8. Rupp F, Scheideler L, Olshanska N, de Wild M, Wieland M, Geis-Gerstorfer J., Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res A. 2006; 76 (2): 323-34.
9. Zhao G, Schwartz Z, Wieland M, Rupp F, Geis-Gerstorfer J, Cochran DL, Boyan BD., High surface energy enhances cell response to titanium substrate microstructure. J Biomed Mater Res A. 2005; 74 (1): 49-58.
10. Olivares-Navarrete R, Hyzy SL, Chaudhri RA, Zhao G, Boyan BD, Schwartz Z., Sex dependent regulation of osteoblast response to implant surface properties by systemic hormones. Biol Sex Differ. 2010; 1 (1): 4.
11. Olivares-Navarrete R, Hyzy SL, Park JH, Dunn GR, Haithcock DA, Wasilewski CE, Boyan BD, Schwartz Z., Mediation of osteogenic differentiation of human mesenchymal stem cells on titanium surfaces by a Wnt-integrin feedback loop. Biomaterials. 2011; 32 (27): 6399-411.
12. Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H., Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res. 1991; 25 (7): 889-902.
13. Gotfredsen K, Wennerberg A, Johansson C, Skovgaard LT, Hjorting-Hansen E., Anchorage of TiO2-blasted, HA-coated, and machined implants: an experimental study with rabbits. J Biomed Mater Res. 1995; 29 (10): 1223-31.
14. Cochran DL, Schenk RK, Lussi A, Higginbottom FL, Buser D., Bone response to unloaded and loaded titanium implants with a sandblasted and acid-etched surface: a histometric study in the canine mandible. J Biomed Mater Res. 1998; 40 (1): 1-11.
15. Schwarz F, Wieland M, Schwartz Z, Zhao G, Rupp F, Geis-Gerstorfer J, Schedle A, Broggini N, Bornstein MM, Buser D, Ferguson SJ, Becker J, Boyan BD, Cochran DL., Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants. J Biomed Mater Res B Appl Biomater. 2009; 88 (2): 544-57.
16. Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL, Hoffmann B, Lussi A, Steinemann SG., Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res. 2004; 83 (7): 529-33.
17. Ferguson SJ, Broggini N, Wieland M, de Wild M, Rupp F, Geis-Gerstorfer J, Cochran DL, Buser D., Biomechanical evaluation of the interfacial strength of a chemically modified sandblasted and acid-etched titanium surface. J Biomed Mater Res A. 2006; 78 (2): 291-7.
18. Raines AL, Olivares-Navarrete R, Wieland M, Cochran DL, Schwartz Z, Boyan BD., Regulation of angiogenesis during osseointegration by titanium surface microstructure and energy. Biomaterials. 2010; 31 (18): 4909-17.
19. Kumar A, Jaffin RA, Berman C., The effect of smoking on achieving osseointegration of surface-modified implants: a clinical report. Int J Oral Maxillofac Implants. 2002; 17 (6): 816-9.
20. Cochran DL., A comparison of endosseous dental implant surfaces. J Periodontol. 1999; 70 (12): 1523-39.
21. Tucci M, Lancaster R, Wingerter S, Woodall J Jr, Russell G, Benghuzzi H., Comparison of segmental fracture healing in young and old rats that were treated with bone stimulators-biomed 2009. Biomed Sci Instrum. 2009; 45: 407-12.
22. Fisher M, Hyzy S, Guldberg RE, Schwartz Z, Boyan BD., Regeneration of bone marrow after tibial ablation in immunocompromised rats is age dependent. Bone. 2010; 46 (2): 396-401.
23. Zinger O, Zhao G, Schwartz Z, Simpson J, Wieland M, Landolt D, Boyan B., Differential regulation of osteoblasts by substrate microstructural features. Biomaterials. 2005; 26 (14): 1837-47.
24. Zhao G, Raines AL, Wieland M, Schwartz Z, Boyan BD., Requirement for both micron- and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topography. Biomaterials. 2007; 28 (18): 2821-9.
25. Bellows CG, Aubin JE, Heersche JN, Antosz ME., Mineralized bone nodules formed in vitro from enzymatically released rat calvaria cell populations. Calcif Tissue Int. 1986; 38 (3): 143-54.
26. Chen J, Olivares-Navarrete R, Wang Y, Herman TR, Boyan BD, Schwartz Z., Protein-disulfide isomerase-associated 3 (Pdia3) mediates the membrane response to 1,25-dihydroxyvitamin D3 in osteoblasts. J Biol Chem. 2010; 285 (47): 37041-50.
27. Wang Y, Chen J, Lee CS, Nizkorodov A, Riemenschneider K, Martin D, Hyzy S, Schwartz Z, Boyan BD., Disruption of Pdia3 gene results in bone abnormality and affects 1alpha,25-dihydroxy-vitamin D3-induced rapid activation of PKC. J Steroid Biochem Mol Biol. 2010; 121 (1-2): 257-60.
28. Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti GP, Fox-Talbot K, Semenza GL, Harmon JW., Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. J Mol Med (Berl). 2011 Oct; 89 (10): 985-95.
29. Shimpo S, Horiguchi Y, Nakamura Y, Lee M, Oikawa T, Noda K, Kuwahara Y, Kawasaki K., Compensatory bone formation in young and old rats during tooth movement. Eur J Orthod. 2003; 25 (1): 1-7.
30. Boyan BD, Schwartz Z, Lohmann CH, Sylvia VL, Cochran DL, Dean DD, Puzas JE., Pretreatment of bone with osteoclasts affects phenotypic expression of osteoblast-like cells. J Orthop Res. 2003; 21 (4): 638-47.
31. Boyan BD, Hummert TW, Dean DD, Schwartz Z., Role of material surfaces in regulating bone and cartilage cell response. Biomaterials. 1996; 17 (2): 137-46.
32. Boyan BD, Lossdorfer S, Wang L, Zhao G, Lohmann CH, Cochran DL, Schwartz Z., Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies. Eur Cell Mater. 2003; 6: 22-7.
33. Zhao G, Zinger O, Schwartz Z, Wieland M, Landolt D, Boyan BD., Osteoblast-like cells are sensitive to submicron-scale surface structure. Clin Oral Implants Res. 2006; 17 (3): 258-64.
34. Schwartz Z, Lohmann CH, Vocke AK, Sylvia VL, Cochran DL, Dean DD, Boyan BD., Osteoblast response to titanium surface roughness and 1alpha,25-(OH)(2)D(3) is mediated through the mitogen-activated protein kinase (MAPK) pathway. J Biomed Mater Res. 2001; 56 (3): 417-26.
35. Keselowsky BG, Wang L, Schwartz Z, Garcia AJ, Boyan BD., Integrin alpha(5) controls osteoblastic proliferation and differentiation responses to titanium substrates presenting different roughness characteristics in a roughness independent manner. J Biomed Mater Res A. 2007; 80 (3): 700-10.
36. Olivares-Navarrete R, Sutha K, Hyzy SL, Hutton DL, Schwartz Z, McDevitt T, Boyan BD., Osteogenic differentiation of stem cells alters vitamin D receptor expression. Stem Cells Dev. Epub. 2012 Jan 4.
37. Raines AL, Sunwoo M, Gertzman AA, Thacker K, Guldberg RE, Schwartz Z, Boyan BD., Hyaluronic acid stimulates neovascularization during the regeneration of bone marrow after ablation. J Biomed Mater Res A. 2011; 96 (3): 575-83.
38. Schwartz Z, Doukarsky-Marx T, Nasatzky E, Goultschin J, Ranly DM, Greenspan DC, Sela J, Boyan BD., Differential effects of bone graft substitutes on regeneration of bone marrow. Clin Oral Implants Res. 2008; 19 (12): 1233-45.