Direct and indirect effects of microstructured titanium substrates on the induction of mesenchymal stem cell differentiation towards the osteoblast lineage

Biomaterials

Volumn 31, Issue 10, 2010, Pages 2728-2735

  Olivares Navarrete, Rene ^a   Hyzy, Sharon L ^a   Hutton, Daphne L ^a   Erdman, Christopher P ^a   Wieland, Marco ^b   Boyan, Barbara D ^a   Schwartz, Zvi ^a,c  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b NanoPowers SA   (Switzerland)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Co culture; Human mesenchymal stem cells; Hydrophilic surfaces; Microstructured surfaces; Osteoblasts; Titanium

Indexed keywords

ALKALINE PHOSPHATASE; COCULTURE; HIGH SURFACE ENERGY; HUMAN MESENCHYMAL STEM CELLS; HYDROPHILIC SURFACES; IN-VITRO; IN-VIVO; INDIRECT EFFECTS; INTEGRINS; MESENCHYMAL STEM CELL; MICROSTRUCTURED SURFACES; OSSEOINTEGRATION; OSTEOBLAST DIFFERENTIATION; OSTEOBLASTIC DIFFERENTIATION; OSTEOCALCIN; PARACRINE; SUBSTRATE PROPERTIES; SUBSTRATE SURFACE; TITANIUM SUBSTRATES; UNDERLYING MECHANISM;

CELL CULTURE; FLOWCHARTING; HYDROPHILICITY; PHOSPHATASES; STEM CELLS; SUBSTRATES; SURFACE CHEMISTRY; SURFACE PROPERTIES; SURFACE TENSION; TITANIUM; TRACE ANALYSIS;

OSTEOBLASTS;

ALKALINE PHOSPHATASE; DICKKOPF 2 PROTEIN; GLYCOPROTEIN; OSTEOCALCIN; TITANIUM; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; CELL DIFFERENTIATION; CELL INTERACTION; CELL LINEAGE; CHEMICAL STRUCTURE; COCULTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYDROPHILICITY; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SURFACE PROPERTY;

CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION REGULATION; GENE SILENCING; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STEM CELLS; OSTEOBLASTS; SURFACE PROPERTIES; TITANIUM;

EID: 75149137836     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.12.029     Document Type: Article

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