Cyclosporin A suppresses prostate cancer cell growth through CaMKKβ/AMPK-mediated inhibition of mTORC1 signaling

Biochemical Pharmacology

Volumn 84, Issue 4, 2012, Pages 425-431

  Lee, Chae Ryun ^a   Chun, Jung Nyeo ^a,b   Kim, Sang Yeob ^c   Park, Soonbum ^a   Kim, Su Hwa ^a   Park, Eun Jung ^a   Kim, In San ^c   Cho, Nam Hyuk ^a   Kim, In Gyu ^a   So, Insuk ^a,b   Kim, Tae Woo ^d   Jeon, Ju Hong ^a,b  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Korea University College of Medicine   (South Korea)

Author keywords

Akt; AMPK; Cyclosporin A; mTOR; Prostate cancer

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE BETA; CYCLOSPORIN A; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MALE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER;

AMP-ACTIVATED PROTEIN KINASES; ANTINEOPLASTIC AGENTS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE; CELL PROLIFERATION; CYCLOSPORINE; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MALE; PHOSPHATIDYLINOSITOLS; PROSTATIC NEOPLASMS; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 84864120335     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.05.009     Document Type: Article

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