Cyclosporin A and tacrolimus induce renal Erk1/2 pathway via ROS-induced and metalloproteinase-dependent EGF-receptor signaling

Biochemical Pharmacology

Volumn 83, Issue 2, 2012, Pages 286-295

  Akool, El Sayed ^a   Gauer, Stefan ^a   Osman, Bashier ^a   Doller, Anke ^a   Schulz, Sebastian ^a   Geiger, Helmut ^a   Pfeilschifter, Josef ^a   Eberhardt, Wolfgang ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

Calcineurin inhibitor; Extracellular regulated kinase; Heparin binding epidermal growth factor; Metalloproteinases; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CYCLOSPORIN A; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STIGMATELLIN; SUPEROXIDE DISMUTASE; TACROLIMUS;

ARTICLE; BINDING KINETICS; CELL PROLIFERATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; EXTRACELLULAR MATRIX; MESANGIUM CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADAM PROTEINS; ANIMALS; CELLS, CULTURED; CYCLOSPORINE; ENZYME INDUCTION; HUMANS; MAP KINASE SIGNALING SYSTEM; MESANGIAL CELLS; METALLOPROTEASES; RATS; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; TACROLIMUS;

EID: 83955163641     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.11.001     Document Type: Article

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