Generalized depletion of free nerve endings and decrease of cutaneous nervous innervation in streptozotocin-induced painful and painless diabetic rats

Journal of the Chinese Medical Association

Volumn 75, Issue 7, 2012, Pages 314-321

  Chu, Chi Chun ^a,b   Wang, Shwun De ^c   Chiang, Joseph S ^d   Ho, Shung Tai ^a,c  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Free nerve endings; Innervation density; Painful diabetic neuropathy; Protein gene product 9.5; Streptozotocin

Indexed keywords

SODIUM CHLORIDE; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; DIABETIC NEUROPATHY; DISEASE DURATION; EPIDERMIS; FOOT PAD; GENE PRODUCT; HISTOPATHOLOGY; HYPERGLYCEMIA; IMMUNOHISTOCHEMISTRY; MALE; NERVE ENDING; NONHUMAN; PAIN THRESHOLD; PERIPHERAL NERVE; RAT; SKIN NERVE; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; MALE; PAIN; PERIPHERAL NERVES; RATS; RATS, SPRAGUE-DAWLEY; SKIN; STREPTOZOCIN; UBIQUITIN THIOLESTERASE;

EID: 84864105907     PISSN: 17264901     EISSN: 17287731     Source Type: Journal    
DOI: 10.1016/j.jcma.2012.05.005     Document Type: Article

References (29)

1. Gore M., Dukes E., Rowbotham D.J., Tai K.S., Leslie D. Clinical characteristics and pain management among patients with painful peripheral neuropathic disorders in general practice settings. Eur J Pain 2007, 11:652-664.
2. Spruce M.C., Potter J., Coppini D.V. The pathogenesis and management of painful diabetic neuropathy: a review. Diabet Med 2003, 20:88-98.
3. Calcutt N.A. Potential mechanisms of neuropathic pain in diabetes. Int Rev Neurobiol 2002, 50:205-228.
4. Veves A., Young M.J., Manes C., Boulton A.J. Differences in peripheral and autonomic nerve function measurements in painful and painless neuropathy. A clinical study. Diabetes Care 1994, 17:1200-1202.
5. Benbow S.J., Chan A.W., Bowsher D., MacFarlane I.A., Williams G. A prospective study of painful symptoms, small-fibre function and peripheral vascular disease in chronic painful diabetic neuropathy. Diabet Med 1994, 11:17-21.
6. Britland S.T., Young R.J., Sharma A.K., Clarke B.F. Acute and remitting painful diabetic polyneuropathy: a comparison of peripheral nerve fibre pathology. Pain 1992, 48:361-370.
7. Johansson O., Wang L., Hilliges M., Liang Y. Intraepidermal nerves in human skin: PGP 9.5 immunohistochemistry with special reference to the nerve density in skin from different body regions. J Peripher Nerv Syst 1999, 4:43-52.
8. Reilly D.M., Ferdinando D., Johnston C., Shaw C., Buchanan K.D., Green M.R. The epidermal nerve fibre network: characterization of nerve fibres in human skin by confocal microscopy and assessment of racial variations. Br J Dermatol 1997, 137:163-170.
9. Lindenlaub T., Sommer C. Epidermal innervation density after partial sciatic nerve lesion and pain-related behavior in the rat. Acta Neuropathol 2002, 104:137-143.
10. Lin Y.W., Tseng T.J., Lin W.M., Hsieh S.T. Cutaneous nerve terminal degeneration in painful mononeuropathy. Exp Neurol 2001, 170:290-296.
11. Graven-Nielsen T., Mense S. The peripheral apparatus of muscle pain: evidence from animal and human studies. Clin J Pain 2001, 17:2-10.
12. Reynolds M.L., Fitzgerald M. Long-term sensory hyperinnervation following neonatal skin wounds. J Comp Neurol 1995, 358:487-498.
13. Aubel B., Kayser V., Mauborgne A., Farre A., Hamon M., Bourgoin S. Antihyperalgesic effects of cizolirtine in diabetic rats: behavioral and biochemical studies. Pain 2004, 110:22-32.
14. Courteix C., Eschalier A., Lavarenne J. Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 1993, 53:81-88.
15. Liu K.S., Hu O.Y., Ho S.T., Tzeng J.I., Chen Y.W., Wang J.J. Antinociceptive effect of a novel long-acting nalbuphine preparation. Br J Anaesth 2004, 92:712-715.
16. Ho S.T., Wang J.J., Huang J.C., Lin M.T., Liaw W.J. The magnitude of acute tolerance to morphine analgesia: concentration-dependent or time-dependent?. Anesth Analg 2002, 95:948-951.
17. Morales M., Wang S.D., Diaz-Ruiz O., Jho D.H. Cannabinoid CB1 receptor and serotonin 3 receptor subunit A (5-HT3A) are co-expressed in GABA neurons in the rat telencephalon. J Comp Neurol 2004, 468:205-216.
18. Morales M., Wang S.D. Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 2002, 22:6732-6741.
19. Shun C.T., Chang Y.C., Wu H.P., Hsieh S.C., Lin W.M., Lin Y.H., et al. Skin denervation in type 2 diabetes: correlations with diabetic duration and functional impairments. Brain 2004, 127:1593-1605.
20. Yam P.S., Dunn L.T., Graham D.I., Dewar D., McCulloch J. NMDA receptor blockade fails to alter axonal injury in focal cerebral ischemia. J Cereb Blood Flow Metab 2000, 20:772-779.
21. Properzi G., Francavilla S., Poccia G., Aloisi P., Gu X.H., Terenghi G., et al. Early increase precedes a depletion of VIP and PGP-9.5 in the skin of insulin-dependent diabetics-correlation between quantitative immunohistochemistry and clinical assessment of peripheral neuropathy. J Pathol 1993, 169:269-277.
22. Pabbidi R.M., Cao D.S., Parihar A., Pauza M.E., Premkumar L.S. Direct role of streptozotocin in inducing thermal hyperalgesia by enhanced expression of transient receptor potential vanilloid 1 in sensory neurons. Mol Pharmacol 2008, 73:995-1004.
23. Smith A.G., Ramachandran P., Tripp S., Singleton J.R. Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy. Neurology 2001, 57:1701-1704.
24. Ellington H.C., Cotter M.A., Cameron N.E., Ross R.A. The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats. Neuropharmacology 2002, 42:966-975.
25. Chu Q., Moreland R., Yew N.S., Foley J., Ziegler R., Scheule R.K. Systemic insulin-like growth factor-1 reverses hypoalgesia and improves mobility in a mouse model of diabetic peripheral neuropathy. Mol Ther 2008, 8:1400-1408.
26. Joseph E.K., Levine J.D. Caspase signalling in neuropathic and inflammatory pain in the rat. Eur J Neurosci 2004, 20:2896-2902.
27. Khan G.M., Chen S.R., Pan H.L. Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats. Neuroscience 2002, 114:291-299.
28. Aley K.O., Levine J.D. Rapid onset pain induced by intravenous streptozotocin in the rat. J Pain 2001, 2:146-150.
29. Chen X., Levine J.D. Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat. Neuroscience 2001, 102:185-192.