The effect of cannabinoids on capsaicin-evoked calcitonin generelated peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats

Neuropharmacology

Volumn 42, Issue 7, 2002, Pages 966-975

  Ellington, Heather C ^a   Cotter, Mary A ^a   Cameron, Norman E ^a   Ross, Ruth A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Anandamide; Cannabinoid; CGRP; Diabetes; Skin; Vanilloid

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANANDAMIDE; CALCITONIN GENE RELATED PEPTIDE; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR AGONIST; CAPSAICIN; NEUROPEPTIDE; RIMONABANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG MECHANISM; IN VITRO STUDY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; RAT; SKIN; STREPTOZOCIN DIABETES;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CANNABINOIDS; CAPSAICIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; HINDLIMB; MALE; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; REFERENCE VALUES; SKIN;

EID: 0036281114     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00040-0     Document Type: Article

References (52)

1. Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor binding in rat brain
2. Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons
3. α, βI, βII, δ and ε protein kinase C isoforms and compound activity in sciatic nerve of normal and diabetic rats
4. The synthetic cannabinoid WIN55212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain
5. Oxidative metabolism of anandamide
6. Effects of diabetes on tissue content and evoked release of calcitonin gene-related peptide-like immunoreactivity from rat sensory nerves
7. Antinociceptive activity of the endogenous fatty acid amide, palmitoylethanolamide
8. Effects of Δ-9 tetrahydrocannabinol on nerve conduction, perfusion and nociception defects in streptozotocin-induced diabetic rats
9. Diabetes causes an early reduction in autonomic ganglion blood flow in rats
10. Effects of chronic alpha-adrenergic receptor blockade on peripheral nerve conduction, hypoxic resistance, polyols, Na(+)-K(+)-ATPase activity, and vascular supply in STZ-D rats
11. Protein kinase C effects on nerve function, perfusion, Na+, K-ATPase activity and glutathione content in diabetic animals
12. Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy
13. Effects of the hydroxyl radical scavenger, dimethylthiourea, on peripheral nerve tissue perfusion, conduction velocity and nociception in experimental diabetes
14. Impaired nociception and pain sensation in mice lacking the capsaicin receptor
15. Effects of dietary supplementation with arachidonic acid rich oils on nerve conduction and blood flow in streptozotocin diabetic rats
16. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the isolated bronchus
17. Supersensitivity to anandamide and enhanced endogenous cannabinoid signalling in mice lacking fatty acid amide hydrolase
18. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
19. Expression of neuropeptides in experimental diabetes; Effects of treatment with nerve growth factor or brain-derived neurotrophic factor
20. Cannabinoid CB1 receptor expression in rat spinal cord
21. The role of central and peripheral cannabinoid(1) receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain
22. Reduced neurogenic inflammation in streptozotocin-diabetic rats due to microvasular changes but not substance P depletion
23. The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
24. Localization of central cannabinoid CB1 receptor messenger RNA in neuronal sub-populations of rat dorsal root ganglia: A double-label in situ hybridization study
25. VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
26. Direct activation of capsaicin receptors by products of lipoxygenase: Endogenous capsaicin-like substances
27. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
28. Role of vanilloid VR1 receptor in thermal allodynia and hyperalgesia in diabetic mice
29. Early increase in CGRP and VIP immunoreactive nerves in skin of streptozotocin-induced diabetic rats
30. Peripheral CGRP as a merker for neurogenic inflammation: A model system of neuropeptide secretion in rat paw skin
31. Protein Kinase C activation and the development of diabetic complications
32. Differential effects of anandamide on basal and evoked release of acetylcholine (ACh) from guinea-pig ileum
33. Cannabinoid inhibition of the capsaicin-induced calcium response in rat dorsal root ganglion neurones
34. Polyol pathway hyperactivity is closely related to carnitine deficiency in the pathogenesis of diabetic neuropathy of streptozotocin-diabetic rats
35. Possible involvement of spinal protein kinase C in the thermal allodynia and hyperalgesia in diabetic mice
36. Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglion neurones and cells ectopically expressing VR1
37. Lipoxygenase products increase monocyte adhesion to human aortic endothelial cells
38. Cannabinoid receptors and pain
39. Induction of vanilloid receptor channel activity by protein kinase C
40. Antihyperalgesic effects of spinal cannabinoids
41. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
42. Actions of cannabinoid receptor ligands on rat cultured sensory neurones: Implications for antinociception
43. Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
44. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
45. Vanilloid (capsaicin) receptors and mechanisms
46. Anandamide excites central terminals of dorsal root ganglion neurons via vanilloid receptor-1 activation
47. The endogenous cannabinoid agonist, anandamide stimulates sensory nerves in guinea-pig airways
48. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
49. Substance P levels in peripheral nerve, skin, atrial myocardium and gastrointestinal tracts of rats with long-term diabetes mellitus
50. Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurones
51. Nerve Growth Factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to excitotoxin capsaicin
52. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide