Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs

Journal of Pharmacological and Toxicological Methods

Volumn 66, Issue 1, 2012, Pages 43-51

  Mooney, Laura ^a   Marks, Louise ^b   Philp, Karen L ^b   Skinner, Matthew ^b   Coker, Susan J ^a   Currie, Susan ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Anaesthesia; Cardiac contractility; Guinea pig; Inotropes; Isoprenaline; Left ventricular dP dtmax; Methods; Ouabain; QA interval; Verapamil

Indexed keywords

ANGIOTENSIN II; FENTANYL; HYPNORM; INOTROPIC AGENT; ISOFLURANE; ISOPRENALINE; MIDAZOLAM; OUABAIN; PENTOBARBITAL; VERAPAMIL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG RESPONSE; ELECTROCARDIOGRAM; GUINEA PIG; HEART HEMODYNAMICS; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE CONTRACTILITY; HEART RATE; MEAN ARTERIAL PRESSURE; NONHUMAN; PR INTERVAL; QRS COMPLEX; QT INTERVAL; SALIVATION; SYSTOLIC BLOOD PRESSURE;

ANESTHESIA; ANESTHETICS; ANIMALS; CARDIOTONIC AGENTS; CAROTID STENOSIS; DRUG ADMINISTRATION ROUTES; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART; HEMODYNAMICS; MALE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; CAVIA; STROPHANTHUS GRATUS;

EID: 84864080579     PISSN: 10568719     EISSN: 1873488X     Source Type: Journal    
DOI: 10.1016/j.vascn.2012.05.008     Document Type: Article

References (22)

1. Adeyemi O., Roberts S., Harris J., West H., Shome S., Dewhurst M. QA interval as an indirect measure of cardiac contractility in the conscious telemeterised rat: Model optimisation and evaluation. Journal of Pharmacological and Toxicological Methods 2009, 60:159-166.
2. Batey A.J., Lightbown I.D., Lambert J.P., Edwards G., Coker S.J. Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea-pigs. British Journal of Pharmacology 1997, 122:563-569.
3. Blake D.W., Korner P.I. Role of baroreceptor reflexes in the hemodynamic and heart rate responses to althesin, ketamine and thiopentone anesthesia. Journal of the Autonomic Nervous System 1981, 3:55-70.
4. Brown J.N., Thorne P.R., Nuttall A.L. Blood pressure and other physiological responses in awake and anesthetized guinea pigs. Laboratory Animal Science 1989, 39:142-148.
5. Buchanan K.C., Burge R.R., Ruble G.R. Evaluation of injectable anesthetics for major surgical procedures in guinea pigs. Contempory Topics in Laboratory Animal Science 1998, 37:58-63.
6. Cambridge D., Whiting M.V. Evaluation of the QA interval as an index of cardiac contractility in anaesthetised dogs: Responses to changes in cardiac loading and heart rate. Cardiovascular Research 1986, 20:444-450.
7. Coleman T.G. Arterial baroreflex control of heart rate in the conscious rat. American Journal of Physiology 1980, 238:H515-H520.
8. Ewen A., Archer D.P., Samanani N., Roth S.H. Hyperalgesia during sedation: effects of barbiturates and propofol in the rat. Canadian Journal of Anaesthesia 1995, 42:532-540.
9. Field K.J., Lang C.M. Hazards of urethane (ethyl carbamate): A review of the literature. Laboratory Animals 1988, 22:255-262.
10. Force T., Kerkelä R. Cardiotoxicity of the new cancer therapeutics - mechanisms of, and approaches to, the problem. Drug Discovery Today 2008, 13:778-784.
11. Hamlin R.L., Del Rio C. An approach to the assessment of drug-induced changes in non-electrophysiological properties of cardiovascular function. Journal of Pharmacological and Toxicological Methods 2010, 62:20-29.
12. Hamlin R.L., Kijtawornrat A., Keene B.W., Hamlin D.M. QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles. Toxicological Sciences 2003, 76:437-442.
13. Hauser D.S., Stade M., Schmidt A., Hanauer G. Cardiovascular parameters in anaesthetized guinea pigs: A safety pharmacology screening model. Journal of Pharmacological and Toxicological Methods 2005, 52:106-114.
14. Librizzi L., Biella G., Cimino C., De Curtis M. Arterial supply of limbic structures in the guinea pig. Journal of Comparative Neurology 1999, 411:674-682.
15. Majewska-Michalska E. The vertebrobasilar arterial system in guinea pig as compared with dog and human. Folia Morphol (Warsz) 1998, 57:121-131.
16. Michael G., Kane K.A., Coker S.J. Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology 2008, 154:1414-1426.
17. Norton K., Iacono G., Vezina M. Assessment of the pharmacological effects of inotropic drugs on left ventricular pressure and contractility: An evaluation of the QA interval as an indirect indicator of cardiac inotropism. Journal of Pharmacological and Toxicological Methods 2009, 60:193-197.
18. Schwenke D.O., Cragg P.A. Comparison of the depressive effects of four anesthetic regimens on ventilatory and cardiovascular variables in the guinea pig. Comparative Medicine 2004, 54:77-85.
19. Svendsen O., Kok L., Lauritzen B. Nociception after intraperitoneal injection of a sodium pentobarbitone formulation with and without lidocaine in rats quantified by expression of neuronal c-fos in the spinal cord-A preliminary study. Laboratory Animals 2007, 41:197-203.
20. Testai L., Calderone V., Salvadori A., Breschi M.C., Nieri P., Martinotti E. QT prolongation in anaesthetized guinea-pigs: An experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates. Journal of Applied Toxicology 2004, 24:217-222.
21. Wallace A.G., Skinner N.S., Mitchell J.H. Hemodynamic determinants of the maximal rate of rise of left ventricular pressure. American Journal of Physiology 1963, 205:30-36.
22. Yao X., Anderson D.L., Ross S.A., Lang D.G., Desai B.Z., Cooper D.C., et al. Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model. British Journal of Pharmacology 2008, 154:1446-1456.