QA interval as an indirect measure of cardiac contractility in the conscious telemeterised rat: Model optimisation and evaluation

Journal of Pharmacological and Toxicological Methods

Volumn 60, Issue 2, 2009, Pages 159-166

  Adeyemi, O ^a   Roberts, S ^a   Harris, J ^a   West, H ^a   Shome, S ^a   Dewhurst, M ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Conscious rat; Contractility; ECG; LVdP dtmax; Methods; Milrinone; QA interval; Salmeterol; Verapamil

Indexed keywords

MILRINONE; SALMETEROL; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY TEMPERATURE; CARDIOVASCULAR PARAMETERS; DRUG SAFETY; ELECTROCARDIOGRAM; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE DP-DT; HEART MUSCLE CONTRACTILITY; HEART RATE; MALE; NONHUMAN; PROCESS OPTIMIZATION; QA INTERVAL; RAT; RELIABILITY; SINGLE DRUG DOSE; SURGICAL TECHNIQUE; TELEMETRY;

ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; CARDIOVASCULAR AGENTS; CONSCIOUSNESS; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; GUIDELINES AS TOPIC; HEART RATE; MALE; MODELS, ANIMAL; MODELS, CARDIOVASCULAR; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY; TELEMETRY; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

ANIMALIA; RATTUS;

EID: 68649104031     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2009.03.006     Document Type: Article

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