Hemolytic anemia in adults: Main causes and diagnostic procedures

Expert Review of Hematology

Volumn 5, Issue 2, 2012, Pages 229-241

  Guillaud, Constance ^a   Loustau, Valentine ^a   Michel, Marc ^a  

^a HENRI MONDOR HOSPITAL   (France)

Author keywords

blood smear; direct antiglobulin test; extracorpuscular hemolytic anemia; extravascular hemolysis; hemolytic anemia; intracorpuscular hemolytic anemia; intravascular hemolysis

Indexed keywords

BILIRUBIN; ERYTHROCYTE ENZYME; HAPTOGLOBIN; LACTATE DEHYDROGENASE; MEMBRANE PROTEIN;

ACANTHOCYTOSIS; ALLOIMMUNIZATION; ALPHA THALASSEMIA; ARSENIC POISONING; AUTOIMMUNE HEMOLYTIC ANEMIA; BETA THALASSEMIA; BLOOD CELL COUNT; BLOOD SMEAR; BLOOD TRANSFUSION REACTION; BURN; CLOSTRIDIUM PERFRINGENS; COOMBS TEST; DIAGNOSTIC PROCEDURE; ELLIPTOCYTOSIS; ENZYME DEFECT; ERYTHROCYTE DISORDER; FAMILY HISTORY; FLOW CYTOMETRY; GLUCOSE 6 PHOSPHATE DEHYDROGENASE DEFICIENCY; GRAM POSITIVE BACTERIUM; HEART VALVE PROSTHESIS; HELLP SYNDROME; HEMOGLOBIN H DISEASE; HEMOLYSIS; HEMOLYTIC ANEMIA; HEREDITARY SPHEROCYTOSIS; HUMAN; HYPERSPLENISM; INTRAVASCULAR HEMOLYSIS; LABORATORY TEST; LEAD POISONING; MALARIA; MARATHON RUNNER; MEAN CORPUSCULAR VOLUME; MEDICAL HISTORY; MUSHROOM POISONING; MYELODYSPLASTIC SYNDROME; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PIROPLASMOSIS; PRIORITY JOURNAL; RETICULOCYTE COUNT; RETICULOCYTOSIS; REVIEW; SICKLE CELL ANEMIA; SNAKEBITE; SPIDER BITE; STOMATOCYTOSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; UREMIA; DRUG TOXICITY; ENZYMOLOGY; ERYTHROCYTE; GENETICS; METABOLISM;

ANEMIA, HEMOLYTIC; COOMBS' TEST; DRUG TOXICITY; ERYTHROCYTES; ERYTHROCYTES, ABNORMAL; HUMANS; MALARIA; MEMBRANE PROTEINS; THROMBOTIC MICROANGIOPATHIES;

EID: 84864080466     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.12.3     Document Type: Review

References (58)

1. Dacie JV. The Haemolytic Anemias (Volumes 1-5). Churchill Livingstone, New York, NY, USA (1985-1995).
2. Summerfi eld GP, Wyatt GP. Human parvovirus infection revealing hereditary spherocytosis. Lancet 2(8463), 1070 (1985).
3. Bratosin D, Mazurier J, Tissier JP et al. Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages: a review. Biochimie 80(2), 173-195 (1998).
4. Genty I, Michel M, Hermine O, Schaeffer A, Godeau B, Rochant H. Characteristics of autoimmune hemolytic anemia in adults: retrospective analysis of 83 cases. Rev. Med. Interne. 23(11), 901-909 (2002).
5. Marchand A, Galen RS, Van Lente F. The predictive value of serum haptoglobin in hemolytic disease. JAMA 243(19), 1909-1911 (1980).
6. Bain BJ. Diagnosis from the blood smear. N. Engl. J. Med. 353, 498-507 (2005).
7. Coombs RRA, Mourant AE, Race RR. In vivo isosensitisation of red cells in babies with haemolytic disease. Lancet 1, 264-266 (1946).
8. Das SS, Chaudhary R, Khetan D. A comparison of conventional tube test and gel technique in evaluation of direct antiglobulin test. Hematology 12(2), 175-178 (2007).
9. Habibi B, Muller A, Lelong F et al. Red cell autoimmunization in a "normal" population. 63 cases. Nouv. Presse Med. 9(43), 3253-3257 (1980).
10. Garratty G. The signifi cance of IgG on the red cell surface. Transfus. Med. Rev. 1(1), 47-57 (1987).
11. Freedman J, Barefoot C. Red blood cell-bound C3d in normal subjects and in random hospital patients. Transfusion 22(6), 511-514 (1982).
12. Hodgson K, Ferrer G, Montserrat E, Moreno C. Chronic lymphocytic leukemia and autoimmunity: a systematic review. Haematologica 96(5), 752-761 (2011).
13. Gehrs BC, Friedberg RC. Autoimmune hemolytic anemia. Am. J. Hematol. 69(4), 258-271 (2002).
14. Garratty G. Immune hemolytic anemia associated with negative routine serology. Semin. Hematol. 42(3), 156-164 (2005).
15. Kamesaki T, Oyamada T, Omine M, Ozawa K, Kajii E. Cutoff value of redblood-cell-bound IgG for the diagnosis of Coombs-negative autoimmune hemolytic anemia. Am. J. Hematol. 84(2), 98-101 (2009).
16. Petz LD, Garratty G. Immune Hemolytic Anemias (2nd Edition). Churchill Livingstone, PA, USA (2004).
17. Noizat-Pirenne F, Tournamille C. Relevance of RH variants in transfusion of sickle cell patients. Transfus Clin. Biol. 18(5-6), 527-535 (2011).
18. Chadebech P, Michel M, Janvier D et al. IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independent of complement activation and FcαRI. Blood 116(20), 4141-4147 (2010).
19. Barros MM, Blajchman MA, Bordin JO. Warm autoimmune hemolytic anemia: recent progress in understanding the immunobiology and the treatment. Transfus. Med. Rev. 24(3), 195-210 (2010).
20. Garbe E, Andersohn F, Bronder E et al. Drug induced immune haemolytic anaemia in the Berlin Case-Control Surveillance Study. Br. J. Haematol. 154(5), 644-653 (2011).
21. Garratty G. Drug-induced immune hemolytic anemia. Hematology Am. Soc. Hematol. Educ. Program 73-79 (2009).
22. Arndt PA, Garratty G. The changing spectrum of drug-induced immune hemolytic anemia. Semin. Hematol. 42(3), 137-144 (2005).
23. Shapira Y, Vaturi M, Sagie A. Hemolysis associated with prosthetic heart valves: a review. Cardiol. Rev. 17(3), 121-124 (2009).
24. Mestres CA, Soo CS, Sim EK, Adebo OA, Yan P, Lee CN. Intravascular hemolysis after mitral valve repair: a word of caution. Eur. J. Cardiothorac. Surg. 6(2), 103-105 (1992).
25. Sadler JE. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood 112(1), 11-18 (2008).
26. Patel A, Patel H, Patel A. Thrombotic thrombocytopenic purpura: the masquerader. South Med. J. 102(5), 504-509 (2009).
27. Jordan J, Kiernan W, Merker HJ, Wenzel M, Beneke R. Red cell membrane skeletal changes in marathon runners. Int. J. Sports Med. 19(1), 16-19 (1998).
28. Vasudev M, Bresnahan BA, Cohen EP, Hari PN, Hariharan S, Vasudev BS. Percussion hemoglobinuria-a novel term for hand trauma-induced mechanical hemolysis: a case report. J. Med. Case Reports 5(1), 508 (2011).
29. Jubault V, De Lacroix-Szmania I, Zittoun J et al. Hemolysis and schizocytosis, malabsorption and the "folate trap": unusual semiological peculiarities associated with vitamin B12 defi ciency. Rev. Med. Interne. 19(12), 921-923 (1998).
30. An X, Mohandas N. Disorders of red cell membrane. Br. J. Haematol. 141(3), 367-375 (2008).
31. Bolton-Maggs PH, Stevens RF, Dodd NJ, Lamont G, Tittensor P, King MJ. Guidelines for the diagnosis and management of hereditary spherocytosis. Br. J. Haematol. 126(4), 455-474 (2004).
32. Zanella A, Izzo C, Rebulla P, Zanuso F, Perroni L, Sirchia G. Acidifi ed glycerol lysis test: a screening test for spherocytosis. Br. J. Haematol. 45(3), 481-486 (1980).
33. Streichman S, Gescheidt Y. Cryohemolysis for the detection of hereditary spherocytosis: correlation studies with osmotic fragility and autohemolysis. Am. J. Hematol. 58(3), 206-212 (1998).
34. Girodon F, Garcon L, Bergoin E et al. Usefulness of the eosin-5′-maleimide cytometric method as a fi rst-line screening test for the diagnosis of hereditary spherocytosis: comparison with ektacytometry and protein electrophoresis. Br. J. Haematol. 140(4), 468-470 (2008).
35. Mohandas N, Gallagher PG. Red cell membrane: past, present, and future. Blood 112(10), 3939-3948 (2008).
36. Stewart GW, O'Brien H, Morris SA, Owen JS, Lloyd JK, Ames JA. Stomatocytosis, abnormal platelets and pseudo-homozygous hypercholesterolaemia. Eur. J. Haematol. 38(4), 376-380 (1987).
37. Allen DW, Manning N. Abnormal phospholipid metabolism in spur cell anemia: decreased fatty acid incorporation into phosphatidylethanolamine and increased incorporation into acylcarnitine in spur cell anemia erythrocytes. Blood 84(4), 1283-1287 (1994).
38. Doll DC, Doll NJ. Spur cell anemia. South Med. J. 75(10), 1205-1210 (1982).
39. Prokocimer M, Potasman I. The added value of peripheral blood cell morphology in the diagnosis and management of infectious diseases-part 1: basic concepts. Postgrad. Med. J. 84(997), 579-585 (2008).
40. Potasman I, Prokocimer M. The added value of peripheral blood cell morphology in the diagnosis and management of infectious diseases-part 2: illustrative cases. Postgrad. Med. J. 84(997), 586-589 (2008).
41. Steinberg MH. In the clinic. Sickle cell disease. Ann. Intern. Med. 155(5), ITC31-ITC15; quiz ITC316 (2011).
42. De Latour RP, Mary JY, Salanoubat C et al. Paroxysmal nocturnal hemoglobinuria: natural history of disease subcategories. Blood 112(8), 3099-3106 (2008).
43. Borowitz M, Craig FE, Digiuseppe JA et al. Clinical Cytometry Society. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by fl ow cytometry. Cytometry B Clin. Cytom. 78(4), 211-230 (2010).
44. Jaffe ER. Hereditary hemolytic disorders and enzymatic defi ciencies of human erythrocytes. Blood 35(1), 116-134 (1970).
45. Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase defi ciency. Lancet 371(9606), 64-74 (2008).
46. Au WY, Lam V, Pang A et al. Glucose-6-phosphate dehydrogenase defi ciency in female octogenarians, nanogenarians, and centenarians. J. Gerontol. A Biol. Sci. Med. Sci. 61(10), 1086-1089 (2006).
47. Prchal JT, Gregg XT. Red cell enzymes. Hematology Am. Soc. Hematol. Educ. Program 19-23 (2005).
48. Zanella A, Fermo E, Bianchi P, Valentini G. Red cell pyruvate kinase defi ciency: molecular and clinical aspects. Br. J. Haematol. 130(1), 11-25 (2005).
49. Cunningham MJ. Update on thalassemia: clinical care and complications. Hematol. Oncol. Clin. North Am. 24(1), 215-227 (2010).
50. Taher AT, Musallam KM, Cappellini MD, Weatherall DJ. Optimal management of β-thalassaemia intermedia. Br. J. Haematol. 152(5), 512-523 (2011).
51. Rund D, Rachmilewitz E. β-Thalassemia. N. Engl. J. Med. 353(11), 1135-1146 (2005).
52. Williamson D. The unstable haemoglobins. Blood Rev. 7(3), 146-163 (1993).
53. Papanikolaou NC, Hatzidaki EG, Belivanis S, Tzanakakis GN, Tsatsakis AM. Lead toxicity update. A brief review. Med. Sci. Monit. 11(10), RA329-RA336 (2005).
54. Michel M, Lafaurie M, Noel V et al. Hemolytic anemia disclosing Wilson's disease. Report of 2 cases. Rev. Med. Interne. 22(3), 280-283 (2001).
55. Romeo L, Apostoli P, Kovacic M, Martini S, Brugnone F. Acute arsine intoxication as a consequence of metal burnishing operations. Am. J. Ind. Med. 32(3), 211-216 (1997).
56. Reid HA. Cobra-Bites. Br. Med. J. 2(5408), 540-545 (1964).
57. Vachvanichsanong P, Dissaneewate P, Mitarnun W. Non-fatal acute renal failure due to wasp stings in children. Pediatr. Nephrol. 11(6), 734-736 (1997).
58. Shichishima T, Ikeda K, Takahashi N et al. Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes. Int. J. Hematol. 91(4), 602-610 (2010).