Cathepsin B-like and hemoglobin-type cysteine proteases: Stage-specific gene expression in Angiostrongy cantonensis

Experimental Parasitology

Volumn 131, Issue 4, 2012, Pages 433-441

  Ni, Fang ^a   Wang, Yinan ^a   Zhang, Jing ^a   Yu, Liang ^a   Fang, Wenzhen ^a   Luo, Damin ^a  

^a XIAMEN UNIVERSITY   (China)

Author keywords

Angiostrongylus cantonensis; Cathepsin B like cysteine protease; Hemoglobin type cysteine protease; Real time PCR; Reverse transcription PCR; Stage specific

Indexed keywords

CATHEPSIN B; CYSTEINE PROTEASE B; CYSTEINE PROTEINASE; HEMOGLOBIN; UNCLASSIFIED DRUG;

AC CATHB 1 GENE; AC CATHB 2 GENE; AC HEM GENE; AMINO ACID SEQUENCE; ANGIOSTRONGYLIASIS; ANGIOSTRONGYLUS CANTONENSIS; ARTICLE; FEMALE; GENE; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE ISOLATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; HAEMONCHUS CONTORTUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARELAPHOSTRONGYLUS TENUIS; PRIORITY JOURNAL; PROTOZOAL GENETICS; RAT; SPECIES INVASION;

3' FLANKING REGION; 5' FLANKING REGION; AMINO ACID SEQUENCE; ANGIOSTRONGYLUS CANTONENSIS; ANIMALS; BASE SEQUENCE; CATHEPSIN B; CLONING, MOLECULAR; CYSTEINE PROTEASES; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIFE CYCLE STAGES; MALE; MOLECULAR SEQUENCE DATA; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, HELMINTH; SEQUENCE ALIGNMENT; SNAILS; SPECIFIC PATHOGEN-FREE ORGANISMS;

ANGIOSTRONGYLUS CANTONENSIS; HAEMONCHUS CONTORTUS; PARELAPHOSTRONGYLUS TENUIS;

EID: 84864032236     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2012.05.014     Document Type: Article

References (32)

1. Abdulla M.H., Lim K.C., Sajid M., McKerrow J.H., Caffrey C.R. Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Medicine 2007, 4:e14.
2. Aldape K., Huizinga H., Bouvier J., Mckerrow J. Naegleria fowleri: characterization of a secreted histolytic cysteine protease. Experimental Parasitology 1994, 78:230-241.
3. Baig S., Damian R.T., Peterson D.S. A novel cathepsin B active site motif is shared by helminth blood feeders. Experimental Parasitology 2002, 101:83-89.
4. Beckham S.A., Law R.H., Smooker P.M., Quinsey N.S., Caffrey C.R., McKerrow J.H., Pike R.N., Spithill T.W. Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite. Journal of Biological Chemistry 2006, 387:1053-1061.
5. Brindley P.J., Kalinna B.H., Dalton J.P., Day S.R., Wong J.Y.M., Smythe M.L., McManus D.P. Proteolytic degradation of host hemoglobin by schistosomes. Molecular and Biochemical Parasitology 1997, 89:1-9.
6. Buxbaum L.U., Denise H., Coombs G.H., Alexander J., Mottram J.C., Scott P. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. Journal of Immunology 2003, 171:3711-3717.
7. Caffrey C.R., Ruppel A. Affinity isolation and characterization of the cathepsin B-like proteinase Sj31 from Schistosoma japonicum. Journal of Parasitology 1997, 83:1112-1118.
8. Caffrey C.R., Mathieu M.A., Gaffney A.M., Salter J.P., Sajid M., Lucas K.D., Franklin C., Bogyo M., McKerrow J.H. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. FEBS Letters 2000, 466:244-248.
9. Caffrey C.R., Salter J.P., Lucas K.D., Khiem D., Hsieh I., Lim K.C., Ruppel A., McKerrow J.H., Sajid M. SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni. Molecular and Biochemical Parasitology 2002, 121:49-61.
10. Correnti J.M., Brindley P.J., Pearce E.J. Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth. Molecular and Biochemical Parasitology 2005, 143:209-215.
11. Cunningham E., McCarthy E., Copley L., Jackson D., Johnson D., Dalton J.P., Mulcahy G. Characterisation of cathepsin B-like cysteine protease of Lepeophtheirus salmonis. Aquaculture 2010, 310:38-42.
12. Dalton J.P., Mulcahy G. Parasite vaccines-a reality?. Veterinary Parasitology 2001, 98:149-167.
13. Dalton J.P., Clough K.A., Jones M.K., Brindley P.J. Characterization of the cathepsinlike cysteine proteinases of Schistosoma mansoni. Infection and Immunity 1996, 64:1328-1334.
14. Duffy M.S., Cevasco D.K., Zarlenga D.S., Sukhumavasi W., Appleton J.A. Cathepsin B homologue at the interface between a parasitic nematode and its intermediate host. Infection and Immunity 2006, 74:1297-1304.
15. Fang W., Xu S., Wang Y., Ni F., Zhang S., Liu J., Chen X., Luo D. ES proteins analysis of Angiostrongylus cantonensis: products of the potential parasitism genes?. Parasitology Research 2010, 106:1027-1032.
16. Han Y.P., Li Z.Y., Li B.C., Sun X., Zhu C.C., Ling X.T., Zheng H.Q., Wu Z.D., Lv Z.Y. Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis. Parasitology Research 2011, 109:369-378.
17. Jasmer D.P., Roth J., Myler P.J. Cathepsin B-like cysteine proteases and Caenorhabditis elegans homologues dominate gene products expressed in adult Haemonchus contortus intestine. Molecular and Biochemical Parasitology 2001, 116:159-169.
18. Laha T., Sripa T., Sripa B. Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis. International Journal of Infectious Diseases 2008, 12:e49-59.
19. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method. Methods 2001, 25:402-408.
20. Liang P., Pardee A.B. Differenfial display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992, 257:967-971.
21. Mahmoudzadeh-Niknam H., McKerrow J.H. Leishmania tropica: cysteine proteases are essential for growth and pathogenicity. Experimental Parasitology 2004, 106:158-163.
22. Oliver E.M., Skuce P.J., McNair, McNair C.M., Knox D.P. Identification and characterization of an asparaginyl proteinase (legumain) from the parasitic nematode, Haemonchus contortus. Parasitology 2006, 133:237-244.
23. Ranjit N., Zhan B., Stenzel D.J., Mulvenna J., Fujiwara R., Hotez P.J., Loukas A. A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus. Molecular and Biochemical Parasitology 2008, 160:90-99.
24. Que X., Ngo H., Lawton J., Gray M., Liu Q., Engel J., Brinen L., Ghosh P., Joiner K.A., Reed S.L. The cathepsin B of Toxoplasma gondii, Toxopain-1, is critical for parasite invasion and rhoptry protein processing. Journal of Biological Chemistry 2002, 277:25791-25797.
25. Sajid M., McKerrow J.H. Cysteine proteases of parasitic organisms. Molecular and Biochemical Parasitology 2002, 120:1-21.
26. Schmittgen T.D. Real-time quantitative PCR. Methods 2001, 25:383-385.
27. Schmittgen T.D., Zakrajsek B.A., Mills A.G., Gorn V., Singer M.J., Reed M.W. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Analytical Biochemistry 2000, 285:194-204.
28. Shompole S., Jasmer D.P. Cathepsin B-like cysteine proteases confer intestinal cysteine protease activity in Haemonchus contortus. Journal of Biological Chemistry 2001, 276:2928-2934.
29. Skelly P.J., Da'dara A., Harn D.A. Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference. International Journal of Parasitology 2003, 33:363-369.
30. Tort J., Brindley P.J., Knox D.P., Wolfe K.H., Dalton J.P. Proteinases and associated genes of parasitic helminths. Advances in Parasitology 1999, 43:161-266.
31. Turk D., Podobnik M., Kuhelj R., Dolinar M., Turk V. Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide. FEBS Letters 1996, 384:211-214.
32. Williamson A.L., Brindley P.J., Knox D.P., Hotez P.J., Loukas A. Digestive proteases of blood-feeding nematodes. Trends in Parasitology 2003, 19:417-423.