Glucocorticoid-induced cell death is mediated through reduced glucose metabolism in lymphoid leukemia cells

Blood Cancer Journal

Volumn 1, Issue 7, 2011, Pages

  Buentke, E ^a   Nordstrom A ^a   Lin, H ^a   Bjorklund A C ^a   Laane, E ^b   Harada, M ^a   Lu, L ^a   Tegnebratt, T ^a   Stone Elander, S ^a   Heyman, M ^a   Soderhall S ^a   Porwit, A ^a   Ostenson C G ^c   Shoshan, M ^a   Tamm, K Pokrovskaja ^a   Grande D ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b North Estonian Regional Hospital   (Estonia)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cell death; Glucocorticoids; Glycolysis; Leukemia

Indexed keywords

DEXAMETHASONE; GLUCOSE; GLUCOSE TRANSPORTER 1; SUCCINIC ACID DIMETHYL ESTER;

APOPTOSIS; ARTICLE; CANCER PATIENT; CELL DEATH; CONTROLLED STUDY; EX VIVO STUDY; FLOW CYTOMETRY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOLYSIS; IMMUNOHISTOCHEMISTRY; LEUKEMIA CELL; LIQUID CHROMATOGRAPHY; LYMPHATIC LEUKEMIA; MASS SPECTROMETRY;

EID: 84864031760     PISSN: None     EISSN: 20445385     Source Type: Journal    
DOI: 10.1038/bcj.2011.27     Document Type: Article

References (21)

1. Warburg O. On the origin of cancer cells. Science 1956; 123: 309-314.
2. Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 2005; 202: 654-662. (Pubitemid 40175840)
3. Boag JM, Beesley AH, Firth MJ, Freitas JR, Ford J, Hoffmann K et al. Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemia. Leukemia 2006; 20: 1731-1737. (Pubitemid 44574984)
4. Gaynon PS, Carrel AL. Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia. Adv Exp Med Biol 1999; 457: 593-605. (Pubitemid 129735357)
5. Greenstein S, Ghias K, Krett NL, Rosen ST. Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 2002; 8: 1681-1694. (Pubitemid 34633722)
6. Kaspers GJ, Pieters R, Van Zantwijk CH, Van Wering ER, Van Der Does-Van Den Berg A, Veerman AJ. Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. Blood 1998; 92: 259-266. (Pubitemid 28303201)
7. Schrappe M, Reiter A, Zimmermann M, Harbott J, Ludwig WD, Henze G et al. Long-term results of four consecutive trials in childhood ALL performed by the ALL-BFM study group from 1981 to 1995. Berlin-Frankfurt-Munster. Leukemia 2000; 14: 2205-2222. (Pubitemid 32042262)
8. Holleman A, Cheok MH, den Boer ML, Yang W, Veerman AJ, Kazemier KM et al. Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med 2004; 351: 533-542.
9. Hulleman E, Kazemier KM, Holleman A, VanderWeele DJ, Rudin CM, Broekhuis MJ et al. Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood 2009; 113: 2014-2021.
10. Distelhorst CW. Recent insights into the mechanism of glucocorticosteroid-induced apoptosis. Cell Death Differ 2002; 9: 6-19. (Pubitemid 34071989)
11. Laane E, Panaretakis T, Pokrovskaja K, Buentke E, Corcoran M, Soderhall S et al. Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members. Haematologica 2007; 92: 1460-1469. (Pubitemid 350144120)
12. Swerdlow SH, Campo E, Lee Harris N, Jaffe ES, Pileri SA, Stein H et al. WHO Classification of Tumours of Haematopoietic and Lymphatic Tissues. The International Agency for Research on Cancer, IARC: Lyon, 2008.
13. Bjorklund E, Mazur J, Soderhall S, Porwit-MacDonald A. Flow cytometric follow-up of minimal residual disease in bone marrow gives prognostic information in children with acute lymphoblastic leukemia. Leukemia 2003; 17: 138-148. (Pubitemid 36175899)
14. Panaretakis T, Pokrovskaja K, Shoshan MC, Grander D. Activation of Bak, Bax, and BH3-only proteins in the apoptotic response to doxorubicin. J Biol Chem 2002; 277: 44317-44326. (Pubitemid 36157866)
15. Thyrell L, Erickson S, Zhivotovsky B, Pokrovskaja K, Sangfelt O, Castro J et al. Mechanisms of interferon-alpha induced apoptosis in malignant cells. Oncogene 2002; 21: 1251-1262. (Pubitemid 34185242)
16. Ling ZC, Hong-Lie C, Ostenson CG, Efendic S, Khan A. Hyperglycemia contributes to impaired insulin response in GK rat islets. Diabetes 2001; 50(Suppl 1): S108-S112. (Pubitemid 32148230)
17. Barata JT, Silva A, Brandao JG, Nadler LM, Cardoso AA, Boussiotis VA. Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med 2004; 200: 659-669. (Pubitemid 39258314)
18. Laane E, Tamm KP, Buentke E, Ito K, Kharaziha P, Oscarsson J et al. Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ 2009; 16: 1018-1029.
19. Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell 2007; 18: 1437-1446. (Pubitemid 46626638)
20. van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options? Eur J Clin Invest 2009; 39: 81-93.
21. Gozuacik D, Kimchi A. Autophagy and cell death. Curr Top Dev Biol 2007; 78: 217-245.