An IP-10 (CXCL10)-derived peptide inhibits angiogenesis

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Yates Binder, Cecelia C ^a,b,c   Rodgers, Margaret ^c   Jaynes, Jesse ^a   Wells, Alan ^a,b,c   Bodnar, Richard J ^b,c   Turner, Timothy ^a  

^a TUSKEGEE UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALPAIN; CHEMOKINE RECEPTOR CXCR3; CYCLIC AMP; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IP 10P; NEUTRALIZING ANTIBODY; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTIANGIOGENIC ACTIVITY; ANTIBODY SPECIFICITY; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INVOLUTION; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RECEPTOR BINDING; RECEPTOR BLOCKING;

AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; ANTIBODIES, NEUTRALIZING; CELL MOVEMENT; CHEMOKINE CXCL10; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDES; PROTEIN BINDING; RECEPTORS, CXCR3; SIGNAL TRANSDUCTION;

EID: 84864018569     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040812     Document Type: Article

References (24)

1. Strieter RM, Burdick MD, Mestas J, Gomperts B, Keane MP, et al. (2006) Cancer CXC chemokine networks and tumour angiogenesis. Eur J Cancer 42: 768-778.
2. Dimberg A, (2010) Chemokines in angiogenesis. Curr Top Microbiol Immunol 341: 59-80.
3. Balestrieri ML, Balestrieri A, Mancini FP, Napoli C, (2008) Understanding the immunoangiostatic CXC chemokine network. Cardiovasc Res 78: 250-256.
4. Godessart N, Kunkel SL, (2001) Chemokines in autoimmune disease. Curr Opin Immunol 6: 670-675.
5. Kelsen SG, Aksoy MO, Yang Y, Shahabuddin S, Litvin J, et al. (2004) The chemokine receptor CXCR3 and its splice variant are expressed in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 287: L584-591.
6. Lasagni L, Francalanci M, Annunziato F, Lazzeri E, Giannini S, et al. (2003) An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med 197: 1537-1549.
7. Bodnar RJ, Yates CC, Wells A, (2006) IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain. Circ Res 98: 617-625.
8. Shiraha H, Glading A, Chou J, Jia Z, Wells A, (2002) Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol 22: 2716-2727.
9. Addison CL, Daniel TO, Burdick MD, Liu H, Ehlert JE, et al. (2009) The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol 165: 5269-5277.
10. Bodnar RJ, Yates CC, Rodgers ME, Du X, Wells A, (2009) IP-10 induces dissociation of newly formed blood vessels. J Cell Sci 122: 2064-2077.
11. Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure 11: 521-532.
12. Clark-Lewis I, Mattioli I, Gong JH, Loetscher P, (2003) Structure-function relationship between the human chemokine receptor CXCR3 and its ligands. J Biol Chem 278: 289-95.
13. Luster AD, Unkeless JC, Ravetch JV, (1985) Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature 15: 672-676.
14. Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, et al. (1992) HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol. 99: 683-90.
15. Yates CC, Whaley D, Kulasekeran P, Hancock WW, Lu B, et al. (2007) Delayed and deficient dermal maturation in mice lacking the CXCR3 ELR-negative CXC chemokine receptor. Am J Pathol 1701: 484-495.
16. Satish L, Yager D, Wells A, (2003) Glu-Leu-Arg-negative CXC chemokine interferon gamma inducible protein-9 as a mediator of epidermal-dermal communication during wound repair. J Invest Dermatol 120: 1110-1117.
17. Satish L, Blair HC, Glading A, Wells A, (2005) Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain. Mol Cell Biol 5: 1922-1941.
18. Ohta K, Shigeishi H, Taki M, Nishi H, Higashikawa K, et al. (2008) Regulation of CXCL9/10/11 in oral keratinocytes and fibroblasts. J Dent Res 87: 1160-1165.
19. Kim S, Bakre M, Yin H, Varner JA, (2002) Inhibition of endothelial cell survival and angiogenesis by protein kinase A. J Clin Invest 110: 933-941.
20. Dimberg A, (2010) Chemokines in angiogenesis. Curr Top Microbiol Immunol 341: 59-80.
21. Yates CC, Whaley D, Y-Chen A, Kulesekaran P, Hebda PA, et al. (2008) ELR-negative CXC chemokine CXCL11 (IP-9/I-TAC) facilitates dermal and epidermal maturation during wound repair. Am J Pathol 173: 643-652.
22. Yates CC, Whaley D, Hooda S, Hebda PA, Bodnar RJ, et al. (2009) Delayed reepithelialization and basement membrane regeneration after wounding in mice lacking CXCR3. Wound Repair Regen. 17: 34-41.
23. Aidoudi S, Bikfalvi A, (2010) Interaction of PF4 (CXCL4) with the vasculature: A role in atherosclerosis and angiogenesis. Thromb Haemost 104: 941-948.
24. Jouan V, Canron X, Alemany M, Caen JP, Quentin G, et al. (1999) Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action. Blood 1 94(3): 984-93.