Protective role of catechin on D-galactosamine induced hepatotoxicity through a p53 dependent pathway

Indian Journal of Clinical Biochemistry

Volumn 25, Issue 4, 2010, Pages 349-356

  Vasanth Raj, P ^a   Nitesh, K ^a   Sagar Gang, S ^a   Hitesh Jagani, V ^a   Raghu Chandrashekhar, H ^a   Venkata Rao, J ^a   Mallikarjuna Rao, C ^a   Udupa, N ^a  

^a MANIPAL COLLEGE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

Bax; Bcl 2; Catechin D galactosamine; Hepatoprotective; Mitochondria; p53

Indexed keywords

EID: 84864014887     PISSN: 09701915     EISSN: 09740422     Source Type: Journal    
DOI: 10.1007/s12291-010-0073-3     Document Type: Article

References (31)

1. Gupta M, Mazumder U, Kumar T, Gomathi P, Kumar R. Antioxidant and hepatoprotective effects of Buhiniaracemosa against paracetamol and carbon tetrachloride induced liver damage in rats. Iranian J Pharma Ther. 2004;3:12-20.
2. Frei B, Higdon J. Antioxidant activity of tea polyphenols in vivo: evidence from animal studies. J Nutr. 2003;133:3275-84.
3. Babich H, Gold T, Gold R. Mediation of the in vitro cytotoxicity of green tea and black tea polyphenols by cobalt chloride. Toxicol Lett. 2005;155:195-205. (Pubitemid 39600752)
4. Okada K, Wangpoengtrakut C, Tanaka T, Tomoyuki T, Toyokuni S, Uchida K, et al. Curcumin and especially tetrahydrocurcumin ameliorate oxidative stress induced renal injury in mice. J Nutr. 2001;131:2090-5. (Pubitemid 32720635)
5. Arts I, Hollman P, Kromhout D. Chocolate as a source of tea flavonoids. Lancet. 1999;61:354-88.
6. Matito C, Mastoraku F, Centelles J, Torres J, Cascante M. Antiproliferative effect of antioxidant polyphenols from grape in murine Hep1c1c7. Eur J Nutr. 2003;42:43-9. (Pubitemid 36286304)
7. Graham H. Green tea composition, consumption and phenol chemistry. Prev Med. 1992;21:334-50.
8. Sato M, Toyazaki H, Yoshioka Y, Yokoi N, Yamasaki T. Structural characteristics for superoxide anion radical scavenging and productive activities of green tea polyphenols including proanthocyanidin dimers. Chem Pharm Bull. 2010;58:98-102.
9. Shimizu K, Kinouchi Shimizu N, Hakamata W, Unno K, Asai T, Oku N. Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice. Biol Pharm Bull. 2010;33:117-21.
10. Ostrowska J, Luczaj W, Kasacka I, Rozanski A, Skrzydlewska E. Green tea protects against ethanol induced lipid peroxidation in rat organs. Alcohol. 2004;32:25-32. (Pubitemid 38452290)
11. El-Beshbishy HA. Hepatoprotective effect of green tea (Camellia sinensis) Extract against tamoxifen-induced liver injury in rats. J Biochem Mol Biol. 2005;38:563-70. (Pubitemid 43240991)
12. Wan Y, Vinson J, Etherton T, Porch J, Lazarus S, Kris-Etherton P. Effects of cocoa powder and dark chocolate on LDL oxidative susceptibility and prostaglandin concentration in humans. Am J Clin Nutr. 2001;74:596-602. (Pubitemid 33015145)
13. Arteel GE, Uesugi T, Bevan LN, Gabele E, Wheeler MD, Mckim SE, et al. Green tea extract protects against early alcohol-induced liver injury in rats. Biol Chem. 2002;383:663-70. (Pubitemid 34506303)
14. Baltaziak M, Skrzydlewska E, Sulik A, Famulski W, Koda M. Green tea as an antioxidant which protects against alcohol induced injury in rats - a histopathological examination. Folia Morphol Warsz. 2004;63:123-6. (Pubitemid 38325229)
15. Skrzydlewska E, Ostrowska J, Stankiewicz A, Farbiszewski R. Green tea as a potent antioxidant in alcohol intoxication. Addict Biol. 2002;7:307-14. (Pubitemid 34848418)
16. Lee Sang ll, Kim Hyo Jung, Boo Young Chool. Effect of green tea and (-)-epigallocatechin gallate on ethanol-induced toxicity in HepG2 cells. Phytother Res. 2008;22:669-74.
17. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys. 1978;186:189-95. (Pubitemid 8290500)
18. Goth L. A simple method for determination of serum catalase activity and revision of the reference range. Clin Chim Acta. 1991;196:143-52.
19. Keegan A, Martini R, Batey R. Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis. J Hepatol. 1995;23:591-600.
20. Galindo MF, Jordan J, Gonzalez-Garcia C, Cena V. Chromaffin cell death induced by 6-hydroxydopamine is independent of mitochondrial swelling and caspase activation. J Neurochem. 2003;84:1066-73. (Pubitemid 36330659)
21. Chaung SS, Lin CC, Lin J, Yu KH, Hsu YF, Yen MH. The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats. Phytother Res. 2003;17:784-91. (Pubitemid 37012263)
22. Nakagiri R, Hashizume E, Kavahashi S, Sakai Y, Kamiya T. Suppression by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury in vitro and in vivo. Biosci Biotechnol Biochem. 2003;67:2641-3. (Pubitemid 39251618)
23. MacDonald JR, Gandolfi AJ, Sipes IG. Structural requirements for cytoprotective agents in galactosamine-induced hepatic necrosis. Toxicol Appl Pharmacol. 1985;81:17-24. (Pubitemid 16234029)
24. Tang XH, Gao L, Gao J, Fan YM, Xu LZ, Zhao XN, et al. Mechanisms of hepatoprotection of Terminalia catappa L. extract on D-galactosamine-induced liver damage. Am J Chin Med. 2004;32:509-19. (Pubitemid 39302669)
25. Cummings MC, Winterford CM, Walker NI. Apoptosis. Am J Surg Pathol. 1997;21:01-88.
26. Kromer G, Reed JC. Mitochondrial control of cell death. Nat Med. 2000;6:513-9. (Pubitemid 30305900)
27. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science. 1997;275:1132-6. (Pubitemid 27097313)
28. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from cytosol to mitochondria during apoptosis. J Cell Biol. 1997;139:1281-92. (Pubitemid 27523214)
29. Green DR, Reed JC. Mitochondria and apoptosis. Science. 1998;281:1309-12. (Pubitemid 28406816)
30. Yan Y, Shay JW, Wright WE, Mumby MC. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biol Chem. 1997;272:15220-6. (Pubitemid 27255539)
31. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003;11:577-90. (Pubitemid 36385115)