Effect of naringenin (citrus flavanone) on lipid profile in ethanol-induced toxicity in rats

Journal of Food Biochemistry

Volumn 36, Issue 4, 2012, Pages 502-511

  Jayachitra, Jayaraman ^a   Nalini, Namasivayam ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BODY WEIGHT; CARBOXYMETHYL CELLULOSE; COLLAGEN CONTENT; FREE FATTY ACID; HIGH-DENSITY LIPOPROTEINS; HMG-COA REDUCTASE; HYPERLIPIDEMIA; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; LIPID PROFILE; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEINS; PLASMA LIPID; VERY LOW DENSITY LIPOPROTEINS;

CHOLESTEROL; COLLAGEN; GLUCOSE; ORGANIC COMPOUNDS; PHOSPHOLIPIDS; PLASMAS; RATS; TISSUE;

ETHANOL;

CITRUS; RATTUS;

EID: 84863991821     PISSN: 01458884     EISSN: 17454514     Source Type: Journal    
DOI: 10.1111/j.1745-4514.2011.00561.x     Document Type: Article

References (53)

1. ARUNA, K., KALPANA, C., VISWANATHAN, P. and MENON, V.P. 2002. Toxic effect of sunflower oil on ethanol treated rats. Hepatol. Res. 24, 125-135.
2. ASHAKUMARI, L. and VIJAYAMMAL, P.L. 1993. Additive effect of alcohol and nicotine on lipid metabolism in rats. Indian J. Exp. Biol. 31, 270-274.
3. BUENING, M.K., CHANG, R.L., HUANG, M.T., FORTNER, J.G., WOOD, A.W. and CONNEY, A.H. 1981. Activation and inhibition of benzo(a) pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids. Cancer Res. 41, 67-72.
4. CARSON, F.L. 1990. Fixation, processing, instrumentation, routine staining. In Histotechnology. A Self-Instructional Text, Vol. 4 (F.L. Carson, ed.) pp. 1-67, ASCP press, Stanford, CA.
5. CHOI, J.S., PARK, K.Y., MOON, S.H., PHEE, S.H. and YOUNG, H.S. 1994. Antimutagenic effect of plant flavonoids in the salmonella assay system. Arch. Pharm. Res. 17, 71-75.
6. ERLUND, I. 2004. Review of the flavonoids quercetin, and naringenin. Dietary sources, Bioactivities, bioavilability, and epidemiology. Nutr. Res. 24, 851-874.
7. FALHOLT, K., FALHOLT, W. and LUND, B. 1973. An easy colorimetric method for routine determination of free fatty acids in plasma. Clin. Chim. Acta 46, 105-111.
8. FANG, T., WANG, Y., MA, Y., SU, W., BAI, Y. and ZHAOP, A. 2006. Rapid LC/MS/MS quantitation assay for naringin and its two metabolites in rats plasma. J. Pharm. Biomed. Anal. 40, 454-459.
9. FOLCH, J., LESS, M. and STANLY, G.H.S. 1957. A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem. 226, 497-509.
10. FOSTER, C.S. and DUNN, O. 1973. Stable reagents for determination of serum triglycerides by a colorimetric Hantzsch condensation method. Clin. Chim. Acta 19, 338-340.
11. FRANCONE, O.L., HAGHPASSAND, M., BENNETT, J.A., ROYER, L. and MCNEISH, J. 1997. Expression of human lecithin: Cholesterol acyltransferase in transgenic mice: Effects on cholesterol efflux, esterification, and transport. J. Lipid Res. 38, 813-822.
12. FRIEDEWALD, W.T., LEAVY, R.I. and FREDRICKSON, D.S. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502.
13. FRIEDMAN, S.L. 2008. Mechanisms of hepatic fibrogenesis. Gastroenterology 134, 1655-1669.
14. GALLI, A., PRICE, D. and CRAB, D. 1999. High level expression of rat class I alcohol dehydrogenase is sufficient for ethanol induced fat accumulation in transduced HeLa cells. Hepatology 29, 1164-1170.
15. GRUNNET, N., KONDRUP, J. and DICH, J. 1985. Effect of ethanol on lipid metabolism in cultured hepatocytes. Biochem. J. 228, 673-681.
16. GUSTARSSON, L. and ALLING, C. 1989. Effect of chronic ethanol exposure on fatty acids of rat brain glycerophospholipids. Alcohol. 6, 139-146.
17. HANNUKSELA, M.L., RAMET, M.E., NISSINEN, A.E.T., LIISANANTTI, M.K. and SAVOLAINEN, M.J. 2003. Effects of ethanol on lipids and atherosclerosis. Pathophysiology 10, 93-103.
18. HITZ, J., STEINMETZ, J. and SIEST, G. 1983. Plasma lecithin: Cholesterol acyltransferase-reference values and effects of xenobiotics. Clin. Chim. Acta 133, 85-96.
19. HOLDEN, J.M., BHAGWAT, S.A. and PATTERSON, K.Y. 2002. Development of a multi-nutrient data quality evaluation system. J. Food Compost. Anal. 15, 339-348.
20. IZZO, C., GRILLO, F. and MURADOR, E. 1981. Improved method for the determination of high density lipoprotein cholesterol I. Isolation of high-density lipo proteins by the use of polyethylene glycol 6000. Clin. Chem. 27, 371-374.
21. JAYANTHI, S., GIFTSON, J., RAJKUMAR, D. and NALINI, N. 2009. Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats. J. Pharm. Pharmacol. 61, 809-817.
22. JEON, S.M., KIM, H.K., KIM, H.J., DO, G.M., JEONG, T.S., PARK, Y.B. and CHOI, M.S. 2007. Hypocholesterolemic and antioxidative effects of naringenin and its two metabolites in high-cholesterol fed rats. Trans. Res. 149, 15-21.
23. KALANT, H. and POIKOLAINEN, K. 1999. Moderate drinking: Concepts, definitions and public health significance. In Health Issues Related to Alcohol Consumption (I. MacDonald, ed.) pp. 1-25, Blackwell Science, London.
24. KNEKT, P., KUMPULAINEN, J., JARVINEN, R., RISSANEN, H., HELIOVAARA, M., REUNANEN, A., HAKULINEN, T. and AROMAA, A. 2002. Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76, 560-568.
25. KORN, E.D. 1962. Lipoprotein lipase (clearing factor). In Methods in Enzymology, Vol. 5 (S.P. Colowick and N.O. Kaplan, eds.) pp. 542-545, Academic Press, New York.
26. KUMAR, M.S., UNNIKRISHNAN, M.K., PATRA, S., MURTHY, K. and SRINIVASAN, K.K. 2003. Naringin and Naringenin inhibit nitrite-induced methemoglobin formation. Pharmazie 58, 564-566.
27. LAKSHMANN, M.R. and VEECH, R.L. 1977. Short and long term effects of ethanol administration in vivo on rat HMG-CoA reductase and cholesterol-7-α-hydroxylase activities. J. Lipid Res. 18, 325-327.
28. LEE, C.H., JEONG, T.S., CHOI, Y.K., HYUN, B.W., OH, G.T., KIM, E.H., KIN, J.R., HAN, J.I. and BOK, S.H. 2001. Anti-atherogenic effect of citrus flavonoids, naringin and naringenin, associated with hepatic ACAT and aortic VAM-1 and MCP-1 in high cholesterol-fed rabbits. Biochem. Biophys. Res. Commun. 284, 681-688.
29. LEE, J.S. 2004. Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. Clin. Chim. Acta 347, 121-128.
30. LEE, M.H., YOON, S. and MOON, J.O. 2004. The flavonoid naringenin inhibits dimethylnitrosamine induced liver damage in rats. Biol. Pharm. Bull. 27, 72-76.
31. LEE, S.H., PARK, Y.B., BAE, K.H., BOK, S.H., KWON, Y.K., LEE, E.S. and CHOI, M.S. 1999. Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methyl glutaryl coenzyme A reductase and acyl coenzyme A: Cholesterol acyltransferase in rats. Ann. Nutr. Metab. 43, 173-180.
32. LELBECH, W.K. 1975. Cirrhosis in the alcoholic and the relation to the volume of alcohol abuse. Ann. N Y Acad. Sci. 252, 85-89.
33. LIEBER, C.S. and SCHMID, R. 1961. The effect of ethanol on fatty acid metabolism; stimulation of hepatic fatty acid synthesis in vitro. J. Clin. Invest. 40, 394-399.
34. LIEBER, C.S., WU, Y.S. and SALMELA, K.S. 1994. Microsomal acetaldehyde oxidation is negligible in the presence of ethanol. Alcoholism 8, 409-423.
35. LOWRY, O.H., ROSEBOROUGH, M.J., FARR, A.L. and RANDALL, R.J. 1951. Protein measurement with Folin-phenol reagent. J. Biol. Chem. 193, 265-275.
36. MACSWEEN, R.N. and BURT, A.D. 1986. Histologic spectrum of alcoholic liver disease. Semin. Liver Dis. 6, 221-232.
37. MASSON, P. 1929. Trichrome stainings and their preliminary techniques. J. Tech. Methods 2, 75-90.
38. MELONI, J.N. and LARANJEIRA, R. 2004. The social and health burden of alcohol abuse. Rev. Bras. Psiquiatr. 1, 7-10.
39. RAJASREE, C.R., RAJAMOHAN, T. and AUGUSTI, K.T. 1999. Biochemical effects of garlic protein on lipid metabolism in alcohol fed rats. Indian J. Exp. Biol. 37, 243-247.
40. RAO, A.V. and RAMAKRISHNAN, S. 1975. Indirect assessment of hydroxymethylglutaryl-CoA reductase (NADPH) activity in liver tissue. Clin. Chem. 21, 1523-1525.
41. RASO, G.M., MELI, R.D., CARLO, G., PACILO, M. and DI CARLO, R. 2001. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci. 68, 921-931.
42. RATTY, A.K. and DAS, N.P. 1988. Effective of flavonoids on non enzymic lipid peroxidation; Structure activity relationship. Biochem. Med. Metab. Biol. 39, 69-79.
43. REHM, J., ROOM, R., GRAHAM, K., MONTEIRO, M., GMEL, G. and SEMPOS, C.T. 2003. The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: An overview. Addiction 98, 1209-1228.
44. SANTOS, K.F., OLIVEIRA, T.T., NAGEM, T.J., PINTO, A.S. and OLIVEIRA, M.G. 1999. Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations. Pharmacol. Res. 40, 493-496.
45. SARAVANAN, N. and NALINI, N. 2007. Effect of 2-hydroxy 4-methoxy benzoic acid on an experimental model of hyperlipidaemia, induced by chronic ethanol treatment. J. Pharm. Pharmacol. 59, 1-6.
46. SARKAR, S.N., CHATTOPADHYAY, S.K. and MAJUMDAR, A.C. 1995. Subacute toxicity of urea herbicide, isoproturon in male rats. Indian J. Exp. Biol. 33, 851-856.
47. SCHOLZ, E.P., ZITRON, E., KIESECKER, C., THOMAS, D., KATHOFER, S., KREUZER, J., BAUER, A., KATUS, H.A., REMPPIS, A., KARLE, C.A. ETAL. 2006. Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656. Nutr. Metab. Cardiovasc. Dis. 17, 666-675.
48. SENTHILKUMAR, R., VISWANATHAN, P. and NALINI, N. 2003. Glycine modulates hepatic lipid accumulation in alcohol induced liver injury. Pol. J. Pharmacol. 55, 603-611.
49. SEO, H.J., JEONG, K.S., LEE, M.K., PARK, Y.B., JUNG, U.J., KIM, H.J. and CHOI, M.S. 2003. Role of naringin supplement in regulation of lipid and ethanol metabolism in rats. Life Sci. 73, 933-946.
50. SZKUDELSKA, K., NOGOWSKI, L., NOWICKA, E. and SZKUDELSKI, T. 2007. In vivo metabolic effect of naringenin in the ethanol consuming rats and the effect of naringenin on adipocytes in vitro. J. Anim. Physiol. Anim. Nutr. 91, 91-99.
51. TAKAHASHI, T., KOBORI, M., SHIMOTO, H. and TSUSHIDA, T. 1998. Structure-activity relationship of flavonoids and the induction of granulolytic or monocytic differentiation in HL 60 human myeloid leukemia cells. Biosci. Biotechnol. Biochem. 62, 2199-2204.
52. WADEHRA, N.R., GANGAL, S.V. and SARMA, P.U. 1985. Combined colorimetric estimation of high-density lipoprotein cholesterol, lowdensity lipoprotein cholesterol, very low-density lipoprotein cholesterol and total cholesterol. Arogya J. Health Sci. 9, 36-41.
53. ZHAO, J., CHEN, H. and LI, Y. 2008. Protective effect of bicyclol on acute alcohol-induced LIVER INJURY IN MICE. EUR. J. PHARMACOL. 586, 322-331.