Pathologic diversity of glioneuronal tumor with neuropil-like islands: A histological and immunohistochemical study with a special reference to isocitrate dehydrogenase 1 (IDH1) in 5 cases

Clinical Neuropathology

Volumn 31, Issue 2, 2012, Pages 67-76

  Ishizawa, Keisuke ^a   Hirose, Takanori ^b   Sugiyama, Kazuhiko ^c   Kageji, Teruyoshi ^d   Nobusawa, Sumihito ^e   Homma, Taku ^a   Komori, Takashi ^f   Sasaki, Atsushi ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

^b TOKUSHIMA PREFECTURAL CENTRAL HOSPITAL   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

^e GUNMA UNIVERSITY   (Japan)

^f TOKYO METROPOLITAN NEUROLOGICAL HOSPITAL   (Japan)

Author keywords

Glioneuronal tumor with neuropil like islands; Immunohistochemistry; Isocitrate dehydrogenase 1 (IDH1); Mutation analysis; Synaptophysin

Indexed keywords

DNA; GADOLINIUM; ISOCITRATE DEHYDROGENASE 1; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE;

ADULT; ARTICLE; ASTROCYTOMA; BRAIN TUMOR; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; DNA SEQUENCE; FEMALE; GENE MUTATION; GLIOBLASTOMA; GLIOMA; GLIONEURONAL TUMOR WITH NEUROPIL LIKE ISLANDS; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NEUROPIL; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROGLIOMA; PRIORITY JOURNAL; TUMOR CLASSIFICATION; TUMOR DIAGNOSIS; TUMOR LOCALIZATION; WORLD HEALTH ORGANIZATION; CASE REPORT; GENETICS; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PATHOLOGY;

ADULT; ASTROCYTOMA; BRAIN NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; ISOCITRATE DEHYDROGENASE; MALE; MIDDLE AGED; OLIGODENDROGLIOMA;

EID: 84863990857     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: 10.5414/NP300402     Document Type: Article

References (19)

1. Teo JG, Gultekin SH, Bilsky M, Gutin P, Rosenblum MK. A distinctive glioneuronal tumor of the adult cerebrum with neuropil-like (including " rosetted" ) islands: report of 4 cases. Am J Surg Pathol. 1999; 23: 502-510
2. Kleihues P, Burger PC, Rosenblum MK, Paulus W, Scheithauer BW. Anaplastic astrocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds). WHO classification of tumours of the central nervous system. Lyon: IARC; 2007. p. 30-32.
3. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009; 360: 765-773
4. Riemenschneider MJ, Jeuken JW, Wesseling P, Reifenberger G. Molecular diagnostics of gliomas: state of the art. Acta Neuropathol. 2010; 120: 567-584.
5. Watanabe T, Nobusawa S, Kleihues P, Ohgaki H. IDH1 mutations are early events in the development of astrocytomas and oligodendrogliomas. Am J Pathol. 2009; 174: 1149-1153
6. Huse J, Nafa K, Ladanyi M, Hedvat C, Rosenblum M. Glioneuronal tumor with neuropil-like islands (GTNI) is characterized by IDH1 R132H mutations [abstract 108]. J Neuropathol Exp Neurol. 2011; 70: 526-527.
7. Huse JT, Nafa K, Shukla N, Kastenhuber ER, Lavi E, Hedvat CV, Ladanyi M, Rosenblum MK. High frequency of IDH-1 mutation links glioneuronal tumors with neuropil-like islands to diffuse astrocytomas. Acta Neuropathol. 2011. in press.
8. Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre PL, Burkhard C, Schüler D, Probst-Hensch NM, Maiorka PC, Baeza N, Pisani P, Yonekawa Y, Yasargil MG, Lütolf UM, Kleihues P. Genetic pathways to glioblastoma: a populationbased study. Cancer Res. 2004; 64: 6892-6899.
9. Keyvani K, Rickert CH, Von Wild K, Paulus W. Rosetted glioneuronal tumor: a case with proliferating neuronal nodules. Acta Neuropathol. 2001; 101: 525-528
10. Prayson RA, Abramovich CM. Glioneuronal tumor with neuropil-like islands. Hum Pathol. 2000; 31: 1435-1438
11. Vajtai I, Reinert MM. Malignant glioneuronal tumor of the adult cerebrum with neuropil-like islands involving " proliferating nodules" : confirmatory report of an unusual variant. Acta Neuropathol. 2007; 113: 711-713.
12. Barbashina V, Salazar P, Ladanyi M, Rosenblum MK, Edgar MA. Glioneuronal tumor with neuropil-like islands (GTNI): a report of 8 cases with chromosome 1p/19q deletion analysis. Am J Surg Pathol. 2007; 31: 1196-1202
13. Perry A, Scheithauer BW, Macaulay RJB, Raffel C, Roth KA, Kros JM. Oligodendrogliomas with neurocytic differentiation. A report of 4 cases with diagnostic and histogenetic implications. J Neuropathol Exp Neurol. 2002; 61: 947-955
14. Perry A, Miller CR, Gujrati M, Scheithauer BW, Zambrano SC, Jost SC, Raghavan R, Qian J, Cochran EJ, Huse JT, Holland EC, Burger PC, Rosenblum MK. Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. Brain Pathol. 2009; 19: 81-90
15. Koperek O, Gelpi E, Birner P, Haberler C, Budka H, Hainfellner JA. Value and limits of immunohistochemistry in differential diagnosis of clear cell primary brain tumors. Acta Neuropathol. 2004; 108: 24-30
16. Wharton SB, Chan KK, Hamilton FA, Anderson JR. Expression of neuronal markers in oligodendrogliomas: an immunohistochemical study. Neuropathol Appl Neurobiol. 1998; 24: 302-308
17. Balss J, Meyer J, Mueller W, Korshunov A, Hartmann C, Von Deimling A. Analysis of the IDH1 codon 132 mutation in brain tumors. Acta Neuropathol. 2008; 116: 597-602
18. Allende DS, Prayson RA. The expanding family of glioneuronal tumors. Adv Anat Pathol. 2009; 16: 33-39
19. Preusser M, Wöhrer A, Stary S, Höftberger R, Streubel B, Hainfellner JA. Value and limitations of immunohistochemistry and gene sequencing for detection of the IDH1-R132H mutation in diffuse glioma biopsy specimens. J Neuropathol Exp Neurol. 2011; 70: 715-723