Increased urinary podocytes following indomethacin suggests drug-induced glomerular injury

Pediatric Nephrology

Volumn 27, Issue 7, 2012, Pages 1111-1117

  Kent, Alison L ^a,b   Brown, Linda ^a   Broom, Margaret ^a   Broomfield, Amy ^a   Dahlstrom, Jane E ^a,b  

^a CANBERRA HOSPITAL   (Australia)

^b The Australian National University   (Australia)

Author keywords

Cytology; Gentamicin; Indomethacin; Kidney; Neonate; Podocyte; Preterm; Urine

Indexed keywords

ALBUMIN; GENTAMICIN; INDOMETACIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG SAFETY; FEMALE; GESTATIONAL AGE; GLOMERULOPATHY; HUMAN; HUMAN CELL; INFANT; MALE; PODOCYTE; PREMATURITY; PRIORITY JOURNAL; URINALYSIS;

ANTI-BACTERIAL AGENTS; CARDIOVASCULAR AGENTS; DRUG THERAPY, COMBINATION; DUCTUS ARTERIOSUS, PATENT; FEMALE; GENTAMICINS; HUMANS; INDOMETHACIN; INFANT, NEWBORN; INFANT, PREMATURE; KIDNEY DISEASES; KIDNEY GLOMERULUS; MALE; PODOCYTES;

EID: 84863989500     PISSN: 0931041X     EISSN: 1432198X     Source Type: Journal    
DOI: 10.1007/s00467-012-2111-2     Document Type: Article

References (46)

1. Newton ER (2005) Preterm labor, preterm premature rupture of membranes, and chorioamnionitis. Clin Perinatol 32:571-600 (Pubitemid 41111992)
2. Naruse K, Fujieda M, Miyazaki E, Hayashi Y, Toi M, Fukui T, Kuroda N, Hiroi M, Kurashige T, Enzan H (2000) An immuno-histochemical study of developing glomeruli in human fetal kidneys. Kidney Int 57:1836-1846 (Pubitemid 30252275)
3. Horster MF, Braun GS, Huber SM (1999) Embryonic renal epi-thelia: Induction, nephrogenesis, and cell differentiation. Physiol Rev 79:1157-1191 (Pubitemid 29473314)
4. Abrahamson DR (1991) Glomerulogenesis in the developing kidney. Semin Nephrol 11:375-389
5. Akima S, Kent A, Reynolds GJ, Gallagher M, Falk MC (2004) Indomethacin and renal impairment in neonates. Pediatr Nephrol 19:490-493 (Pubitemid 38594285)
6. Gilbert T, Gaonach S, Moreau E, Merlet-Benichou C (1994) Defect of nephrogenesis induced by gentamicin in rat metanephric organ culture. Lab Invest 70:656-666 (Pubitemid 24181178)
7. Black MJ, Wang Y, Bertram JF (2002) Nephron endowment and renal filtration surface area in young spontaneously hypertensive rats. Kidney Blood Press Res 25:20-26 (Pubitemid 34136838)
8. Skov K, Nyengaard JR, Korsgaard N, Mulvany MK (1994) Number and size of renal glomeruli in spontaneously hypertensive rats. J Hypertension 12:1373-1376
9. Brenner BM, Chertow GM (1994) Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury. Am J Kidney Dis 23:171-175 (Pubitemid 24075306)
10. Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Eng J Med 348:101-108 (Pubitemid 36056716)
11. Zumrutdal AO, Turan C, Cetin F, Adanali S (2002) Relationship between renal size and hypertension in patients with chronic renal failure. Nephron 90:145-147 (Pubitemid 34701988)
12. Kent AL, Maxwell LE, Koina ME, Falk MC, Willenborg D, Dahlstrom JE (2007) Renal glomeruli and tubular injury following indomethacin, ibuprofen and gentamicin exposure in a neonatal rat model. Pediatr Res 62:307-312 (Pubitemid 47301480)
13. Mundel P, Kriz W (1995) Structure and function of podocytes: an update. Anat Embryol (Berl) 192:385-397
14. Kerjaschki D (2001) Caught flat-footed: Podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 108:1583-1587 (Pubitemid 33144868)
15. Pagtalunan ME, Miller PL, Jumping-Eagle S, Nelson RG, Myer BD, Rennke HG, Coplon NS, Sun L, Meyer TW (1997) Podocyte loss and progressive glomerular injury in Type II diabetes. J Clin Invest 99:342-348 (Pubitemid 27053474)
16. Nakamura T, Ushiyama C, Suzuki S, Hara M, Shimada N, Ebihara I, Koide H (2000) Urinary excretion of podocytes in patients with diabetic nephropathy. Nephrol Dial Transplant 15:1379-1383
17. Welsh GI, Coward RJ (2010) Podocytes, glucose and insulin. Curr Opin Nephrol Hypertens 19:379-384
18. Benoit G, Machuca E, Antignac C (2010) Hereditary nephrotic syndrome: a systematic approach for genetic testing and a review of associated podocyte gene mutations. Pediatr Nephrol 25:1621-1632
19. Mundel P, Reiser J (2010) Proteinuria: an enzymatic disease of the podocyte. Kidney Int 77:571-580
20. Stitt-Cavanagh E, MacLeod L, Kennedy C (2009) The podocyte in diabetic kidney disease. Sci World J 14:1127-1139
21. Vogelmann SU, Nelson WJ, Myers BD, Lemley KV (2003) Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol 285:F40-F48 (Pubitemid 36818460)
22. Hara M, Yanagihara T, Takada T, Itoh M, Matsuno M, Yamamoto T, Kihara I (1998) Urinary exretion of podocytes reflects disease activity in children with glomerulonephritis. Am J Nephrol 18:35-41 (Pubitemid 28043794)
23. Kanno K, Kawachi H, Uchida Y, Hara M, Shimizu F, Uchiyama M (2003) Urinary sediment podocalyxin in children with glomerular diseases. Nephron Clin Pract 95:c91-c99
24. Hara M, Yamamoto T, Yanagihara T, Takada T, Itoh M, Adachi Y, Yoshizumi A, Kawasaki K, Kihara I (1995) Urinary excretion of podocalyxin indicates glomerular epithelial cell injuries in glomer-ulonephritis. Nephron 69:397-403
25. Yu D, Petermann A, Kunter U, Rong S, Shankland SJ, Floege J (2005) Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria. J Am Soc Nephrol 16:1733-1741 (Pubitemid 41716479)
26. Hara M, Yanagihara T, Kihara I (2007) Cumulative excretion of urinary podocytes reflects disease progression in IgA nephropathy and Schönlein-Henoch purpura nephritis. Clin J Am Soc Nephrol 2:231-238
27. Petermann A, Floege J (2007) Podocyte damage resulting in podo-cyturia: a potential diagnostic marker to assess glomerular disease activity. Nephron Clin Pract 106:c61-c66 (Pubitemid 46933393)
28. Bariety J, Mandet C, Hill GS, Bruneval P (2006) Parietal podo-cytes in normal human glomeruli. J Am Soc Nephrol 17:2770-2780 (Pubitemid 44484667)
29. Vieux R, Fresson J, Guillemin F, Hascoet JM (2011) Perinatal drug exposure and renal function in very preterm infants. Arch Dis Child Fetal Neonatal Ed 96:F290-F295
30. Vieux R, Desandes R, Boubred F, Semana D, Guillemin F, Buchweiller M-C, Fresson J, Hascoet J-M (2010) Ibuprofen in very preterm infants impairs renal function for the first month of life. Pediatr Nephrol 25:267-274
31. Gubhaju L, Sutherland MR, Yoder BA, Zulli A, Bertram JF, Black MJ (2009) Is nephrogenesis affected by preterm birth? Studies in a non-human primate model. Am J Physiol Renal Physiol 297: F1668-F1677
32. Rodriguez MM, Gomez A, Abitbol C, Chandar J, Montane B, Zilleruelo G (2005) Comparative renal histomorphometry: a case study of oligonephropathy of prematurity. Pediatr Nephrol 20:945-949 (Pubitemid 40909266)
33. Rodriguez MM, Gomez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE (2004) Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol 7:17-25 (Pubitemid 38520228)
34. Manalich R, Reyes L, Herrera M, Melendi C, Rundora I (2000) Relationship between weight at birth and the number and size of renal glomeruli in humans: a histomorphometric study. Kidney Int 58:770-773 (Pubitemid 30620027)
35. Faa G, Gerosa C, Fanni D, Nemolato S, Locci A, Cabras T, Marinelli V, Puddu M, Zaffanello M, Monga G, Fanos V (2010) Marked interindividual variability in renal maturation of preterm infants: lessons from autopsy. J Matern Fetal Neonatal Med 23 (Suppl 3):129-133
36. Sutherland MR, Gubhaju L, Moore L, Kent AL, Dahlstrom JE, Horne RS, Hoy W, Bertram JF, Black MJ (2011) Accelerated Maturation and Abnromal Morphology in the Preterm Neonatal Kidney. JASN 22:1365-1374
37. Brenner BM, Garcia DL, Anderson S (1988) Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1:335-347
38. Hoy WE, Hughson MD, Singh GR, Douglas-Denton R, Bertram JF (2006) Reduced nephron number and glomerulomegaly in Australian Aborigines: A group at high risk for renal disease and hypertension. Kidney Int 70:104-110 (Pubitemid 44000126)
39. Bonamy A-KE, Bendito A, Martin H, Andolf E, Sedin G, Norman M (2005) Preterm birth contributes to increased vascular resistance and higher blood pressure in adolescent girls. Pediatr Res 58:845-849 (Pubitemid 41511052)
40. Kistner A, Celsi G, Vanpee M, Jacobson SH (2005) Increased systolic daily ambulatory blood pressure in adult women born preterm. Pediatr Nephrol 20:232-233 (Pubitemid 40174043)
41. Johansson S, Iliadou A, Bergvall N, Tuvemo T, Norman M, Cnattingius S (2005) Risk of high blood pressure among young men increases with degree of immaturity at birth. Circulation 112:3430-3436 (Pubitemid 43739558)
42. Keijzer-Veen MG, Dulger A, Dekker FW, Nauta J, van der Heijden BJ (2010) Very preterm birth is a risk factor for increased systolic blood pressure at a young adult age. Pediatr Nephrol 25:509-516
43. Rodriguez-Soriano J, Aguirre M, Oliveros R, Vallo A (2005) Long-term renal follow-up of extremely low birth weight infants. Pediatr Nephrol 20:579-584 (Pubitemid 41166610)
44. Huang H-P, Tsai I-J, Lai Y-C, Cheng C-H, Tsau Y-K (2007) Early postnatal renal growth in premature infants. Nephrol 12:572-575 (Pubitemid 350059136)
45. Kent AL, Jyoti R, Robertson C, Gonsalves L, Meskell S, Shadbolt B, Falk MC (2009) Does extreme prematurity affect kidney volume at term corrected age? J Matern Fetal Neonatal Med 22:435-438
46. Keijzer-Veen MG, Devos AS, Meradji M, Dekker FW, Nauta J, van der Heijden BJ (2010) Reduced renal length and volume 20 years after very preterm birth. Pediatr Nephrol 25:499-507