Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin- 3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 15, 2012, Pages 4986-4989

  Dzierba, Carolyn D ^a   Sielecki, Thais M ^a   Arvanitis, Argyrios G ^a   Galka, Amy ^a   Johnson, Tricia L ^a   Takvorian, Amy G ^a   Rafalski, Maria ^a   Kasireddy Polam, Padmaja ^a   Vig, Shikha ^a   Dasgupta, Bireshwar ^a   Zhang, Ge ^a   Molski, Thaddeus F ^a   Wong, Harvey ^a   Zaczek, Robert C ^a   Lodge, Nicholas J ^a   Combs, Andrew P ^a   Gilligan, Paul J ^a   Trainor, George L ^a   Bronson, Joanne J ^a   MacOr, John E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Anxiety; Corticotropin releasing factor; Depression

Indexed keywords

CORTICOTROPIN RELEASING FACTOR ANTAGONIST; PTERIDIN 7(8H)ONE DERIVATIVE; PTERIDINE; PYRAZINE DERIVATIVE; PYRIDO[3,2 B]PYRAZIN 3(4H)ONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ANXIETY AGENTS; HALF-LIFE; PTERIDINES; PYRAZINES; RATS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863988322     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.06.034     Document Type: Article

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