Evaluation of novel saponins from Psammosilene tunicoides and their analogs as immunomodulators

International Immunopharmacology

Volumn 14, Issue 1, 2012, Pages 21-26

  Zhang, Jigang ^a   Cao, Wenjie ^b   Tian, Junmian ^a   Yue, Rongcai ^a   Li, Li ^c   Guo, Baoyu ^a   Shan, Lei ^a   Yu, Biao ^b   Zhang, Weidong ^a,d  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Adjuvanticity; Psammosilene tunicoides; Saponins; Toxicity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBOXYL GROUP; GAMMA INTERFERON; GLUCURONIC ACID; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B; IMMUNOMODULATING AGENT; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; PLANT EXTRACT; PSAMMOSILENE TUNICOIDES EXTRACT; QUIL A; SAPONIN DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; TUNICOSAPONIN A1; TUNICOSAPONIN A2; TUNICOSAPONIN A3; TUNICOSAPONIN A4; TUNICOSAPONIN E1; TUNICOSAPONIN E2; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; HEMOLYSIS; HUMORAL IMMUNITY; HYDROPHOBICITY; LIVER TOXICITY; MALE; MEDICINAL PLANT; MORTALITY; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PSAMMOSILENE TUNICOIDES; SPLEEN CELL; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CARBOHYDRATES; CARYOPHYLLACEAE; CELLS, CULTURED; HEMOLYSIS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOLOGIC FACTORS; IMMUNOMODULATION; LIVER; MICE; MICE, INBRED ICR; OLEANOLIC ACID; RABBITS; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863972284     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.06.006     Document Type: Article

References (31)

1. C.D. Skene, and P. Sutton Saponin-adjuvanted particulate vaccines for clinical use Methods 40 2006 53 59 (Pubitemid 44415498)
2. C.R. Kensil, and R. Kammer QS-21: a water-soluble triterpene glycoside adjuvant Expert Opin Investig Drugs 7 1998 1475 1482 (Pubitemid 28408808)
3. S. Soltysik, J.Y. Wu, J. Recchia, D.A. Wheeler, M.J. Newman, and R.T. Coughlin Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function Vaccine 13 1995 1403 1410
4. H. Takahashi, T. Takeshfta, B. Morein, S. Putney, R.N. Germain, and J.A. Berzofsky Induction of CD8+ cytotoxic T cells by immunization with purified HIV-1 envelope protein in ISCOMs Nature 344 1990 873 875
5. R. Bomford Saponin and other haemolysins (vitamin A, aliphatic amines, polyene antibiotics) as adjuvants for SRBC in the mouse Int Arch Allergy Appl Immunol 63 1980 170 177
6. J.L. Cleland, C.R. Kensil, A. Lim, N.E. Jacobsen, L. Basa, and M. Spellman Isomerization and formulation stability of the vaccine adjuvant QS-21 J Pharm Sci 85 1996 22 28 (Pubitemid 26029625)
7. C.R. Kensil, J. Wu, and S. Soltysik Structural and immunological characterization of the vaccine adjuvant QS-21 Pharm Biotechnol 6 1995 525 541
8. C.R. Kensil, U. Patel, M. Lennick, and D. Marciani Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex J Immunol 146 1991 431 437
9. G. Liu, C. Anderson, H. Scaltreto, J. Barbon, and C.R. Kensil QS-21 structure/function studies: effect of acylation on adjuvant activity Vaccine 20 2002 2808 2815 (Pubitemid 34597141)
10. D.J. Marciani, A.K. Pathak, R.C. Reynolds, L. Seitz, and R.D. May Altered immunomodulating and toxicological properties of degraded Quillajia saponaria Molina saponins Int Immunopharmacol 1 2001 813 818 (Pubitemid 32206543)
11. K. Oda, H. Matsuda, T. Murakami, S. Katayama, T. Ohgitani, and M. Yoshikawa Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants Biol Chem 381 2000 67 74 (Pubitemid 30102877)
12. W.R. Santos, E.P. Souza, R.R. Bernardo, M. Palatnik, and C.B. Palatnik Saponins, IL12 and BCG adjuvant in the FML-vaccine formulation against murine visceral leishmaniasis Vaccine 21 2002 30 43 (Pubitemid 35355720)
13. D.C. Waite, E.W. Jacobson, F.A. Ennis, R. Edelman, B. White, and R. Kammer Three double-blind, randomized trials evaluating the safety and tolerance of different formulations of the saponin adjuvant QS-21 Vaccine 19 2001 3957 3967 (Pubitemid 32566320)
14. B. Karanam, R. Gambhira, S. Peng, S. Jagu, D.J. Kim, and G.W. Ketner Vaccination with HPV16 L2E6E7 fusion protein in GPI-0100 adjuvant elicits protective humoral and cell-mediated immunity Vaccine 27 2009 1040 1049
15. D.J. Marciani, J.B. Press, R.C. Reynolds, A.K. Pathak, V. Pathak, and L.E. Gundy Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity Vaccine 18 2000 3141 3151 (Pubitemid 30345696)
16. D. Quenelle, D. Collins, D. Marciani, and E. Kern Effect of immunization with herpes simplex virus type-1 (HSV-1) glycoprotein d (gD) plus the immune enhancer GPI-0100 on infection with HSV-1 or HSV-2 Vaccine 24 2006 1515 1522 (Pubitemid 43238225)
17. D. Quenelle, D. Collins, T. Rice, M. Prichard, D. Marciani, and E. Kern Effect of an immune enhancer, GPI-0100, on vaccination with live attenuated herpes simplex virus (HSV) type 2 or glycoprotein d on genital HSV-2 infections of guinea pigs Antiviral Res 80 2008 223 224
18. X.M. Song, S.J. Bao, L.H. Wu, and S.H. Hu Ginseng stem-leaf saponins (GSLS) and mineral oil act synergistically to enhance the immune responses to vaccination against foot-and-mouth disease in mice Vaccine 27 2009 51 55
19. J.H. Sun, S.H. Hu, and X.M. Song Adjuvant effects of protopanaxadiol and protopanaxatriol saponins from ginseng roots on the immune responses to ovalbumin in mice Vaccine 25 2007 1114 1120
20. Z.G. Yang, H.X. Sun, and W.H. Fang Haemolytic activities and adjuvant effect of Astragalus membranaceus saponins (AMS) on the immune responses to ovalbumin in mice Vaccine 23 2005 5196 5203
21. E. Yesilada, E. Bedir, I. Calis, Y. Takaishi, and Y. Ohmoto Effects of triterpene saponins from Astragalus species on in vitro cytokine release J Ethnopharmacol 96 2005 71 77 (Pubitemid 39575033)
22. H.X. Sun, Z.G. Yang, and Y.P. Ye Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng Int Immunopharmacol 6 2006 14 25
23. H.X. Sun, F. Qin, and Y.P. Ye Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng Vaccine 23 2005 5533 5542 (Pubitemid 41608602)
24. Y. Xie, H.J. Pan, H.X. Sun, and D. Li A promising balanced Th1 and Th2 directing immunological adjuvant, saponins from the root of Platycodon grandiflorum Vaccine 26 2008 3937 3945
25. X.X. Li, and J.Z. Qin Modulation of Toll-interleukin 1 receptor mediated signaling J Mol Med 83 2005 258 266
26. Y.X. Sun, H.B. Tong, M.Q. Li, Y.J. Li, S.W. Guan, and J.C. Liu Immunological adjuvant effect of Japanese ginseng saponins (JGS) on specific antibody and cellular response to ovalbumin and its haemolytic activities Vaccine 26 2008 5911 5917
27. H.X. Sun, H. Wang, H.S. Xu, and Y. Ni Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity Vaccine 27 2009 3984 3991
28. K. Hostettmann, and A. Marston Saponins 1995 Cambridge Univ Pr Cambridge
29. J.C. Cox, and A.R. Coulter Adjuvants - a classification and review of their modes of action Vaccine 5 1997 48 56
30. W.P. Jiang, W.J. Swiggard, C. Heufler, M. Peng, A. Mirza, and R.M. Steinman The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing Nature 375 1995 151 155
31. P.D. Stahl The mannose receptor and other macrophage lectins Curr Opin Immunol 4 1992 49 52