Chemoselective cyclization of unprotected linear peptides by α-ketoacid-hydroxylamine amide-ligation

Organic and Biomolecular Chemistry

Volumn 10, Issue 30, 2012, Pages 5837-5844

  Fukuzumi, Takeo ^a   Ju, Lei ^a   Bode, Jeffrey W ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALTERNATIVE APPROACH; AMIDE BOND; CHEMOSELECTIVE; CYCLIC PEPTIDES; DRUG CANDIDATES; LINEAR PEPTIDES; LINEAR PRECURSORS; MACROCYCLES; METABOLIC STABILITY; MULTI-STEP; NATURAL PRODUCTS; PROTECTING GROUP; RING SIZES; SIDE-CHAIN FUNCTIONALITIES; SIDE-CHAINS; SOLID PHASE PEPTIDE SYNTHESIS;

AMIDES; AMINES; BIOCHEMISTRY; CHEMICAL REACTIONS; LEAD COMPOUNDS; PEPTIDES;

CYCLIZATION;

AMIDE; BIOLOGICAL PRODUCT; CYCLOPEPTIDE; HYDROXYLAMINE; OXOACID;

AMINO ACID SEQUENCE; ARTICLE; CHEMISTRY; CYCLIZATION; ENZYME SPECIFICITY; STEREOISOMERISM;

AMIDES; AMINO ACID SEQUENCE; BIOLOGICAL AGENTS; CYCLIZATION; HYDROXYLAMINE; KETO ACIDS; PEPTIDES, CYCLIC; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84863960580     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/c2ob25129a     Document Type: Article

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