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Volumn 37, Issue 3, 1998, Pages 347-349

Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization

Author keywords

Cyclizations; Peptides; Protein structures; Solid phase synthesis

Indexed keywords


EID: 0032536553     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-3773(19980216)37:3<347::AID-ANIE347>3.0.CO;2-5     Document Type: Article
Times cited : (103)

References (33)
  • 1
    • 0029645122 scopus 로고
    • a) T. W. Muir, Structure 1995, 3, 649-652;
    • (1995) Structure , vol.3 , pp. 649-652
    • Muir, T.W.1
  • 13
    • 0001631118 scopus 로고
    • b) H. Kessler, Angew. Chem. 1982, 94, 509-520; Angew. Chem. Int. Ed. Engl. 1982, 21, 512-523;
    • (1982) Angew. Chem. , vol.94 , pp. 509-520
    • Kessler, H.1
  • 14
    • 0020163940 scopus 로고
    • b) H. Kessler, Angew. Chem. 1982, 94, 509-520; Angew. Chem. Int. Ed. Engl. 1982, 21, 512-523;
    • (1982) Angew. Chem. Int. Ed. Engl. , vol.21 , pp. 512-523
  • 19
    • 0030424581 scopus 로고    scopus 로고
    • WW domains are a novel class of protein modules which are found in a variety of signal-transducing and cytoskeletal proteins. Reviews: a) M. Sudol, Prog. Biophys. Molec. Biol. 1996, 65, 113-132; b) M. Sudol, H. I. Chen, C. Bougeret, A. Einbond, P. Bork, FEBS Letters 1995, 369, 67-71.
    • (1996) Prog. Biophys. Molec. Biol. , vol.65 , pp. 113-132
    • Sudol, M.1
  • 20
    • 0029146950 scopus 로고
    • WW domains are a novel class of protein modules which are found in a variety of signal-transducing and cytoskeletal proteins. Reviews: a) M. Sudol, Prog. Biophys. Molec. Biol. 1996, 65, 113-132; b) M. Sudol, H. I. Chen, C. Bougeret, A. Einbond, P. Bork, FEBS Letters 1995, 369, 67-71.
    • (1995) FEBS Letters , vol.369 , pp. 67-71
    • Sudol, M.1    Chen, H.I.2    Bougeret, C.3    Einbond, A.4    Bork, P.5
  • 22
    • 0347397212 scopus 로고    scopus 로고
    • To facilate native ligation, Cys and Gly were added at the N and C termini, respectively, of the core WW sequence (residues 165-209 of the human YAP protein)
    • To facilate native ligation, Cys and Gly were added at the N and C termini, respectively, of the core WW sequence (residues 165-209 of the human YAP protein).
  • 23
    • 0348027966 scopus 로고    scopus 로고
    • Cyclic protein 2 was digested with trypsin, and the peptide fragment encompassing the ligation site (AMLSQGCFEIPDDVPLPAG- WEMAK) characterized by Edman sequencing
    • Cyclic protein 2 was digested with trypsin, and the peptide fragment encompassing the ligation site (AMLSQGCFEIPDDVPLPAG- WEMAK) characterized by Edman sequencing.
  • 25
    • 0346136144 scopus 로고    scopus 로고
    • The linear WW domain was also chemically synthesized by Boc solidphase protein synthesis and purified by standard procedures
    • The linear WW domain was also chemically synthesized by Boc solidphase protein synthesis and purified by standard procedures.
  • 26
    • 0346136143 scopus 로고    scopus 로고
    • Residues located at the immediate N and C termini could not be unambiguously assigned in either the linear or cyclic WW domains
    • Residues located at the immediate N and C termini could not be unambiguously assigned in either the linear or cyclic WW domains.
  • 27
    • 0001617183 scopus 로고
    • Large effective molarities were described for many intramolecular organic reactions: F. M. Menger, Acc. Chem. Res. 1985, 75, 128-134.
    • (1985) Acc. Chem. Res. , vol.75 , pp. 128-134
    • Menger, F.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.