Increased T-allele frequency of 677 C>T polymorphism in the methylenetetrahydrofolate reductase gene in differentiated thyroid carcinoma

Genetic Testing and Molecular Biomarkers

Volumn 16, Issue 7, 2012, Pages 780-784

  Ozdemir, Semra ^a   Silan, Fatma ^a   Hasbek, Zekiye ^b   Uludag, Ahmet ^a   Atik, Sinem ^a   Erselcan, Taner ^b   Ozdemir, Ozturk ^a,b  

^a ÇANAKKALE ONSEKIZ MART UNIVERSITY   (Turkey)

^b CUMHURIYET UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); EDETIC ACID;

ADULT; AGED; ARTICLE; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CONTROLLED STUDY; DIFFERENTIATED THYROID CANCER; DNA EXTRACTION; DNA POLYMORPHISM; FEMALE; FOLLICULAR THYROID CARCINOMA; GENE FREQUENCY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; REAL TIME POLYMERASE CHAIN REACTION; THYROID CARCINOMA;

ADENOCARCINOMA, FOLLICULAR; AGED; AGED, 80 AND OVER; ALLELES; CARCINOMA; CASE-CONTROL STUDIES; DNA METHYLATION; FEMALE; GENE FREQUENCY; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; NEOPLASM PROTEINS; POLYMORPHISM, GENETIC; THYROID NEOPLASMS;

EID: 84863954167     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2011.0347     Document Type: Article

References (34)

1. Arslan S, Karadayi S, Ozdemir O, et al. (2010) Tissue specific epigenetic silencing of the distinct tumor suppressor genes in lung cancer. Sci Res Essays 5:849-855.
2. Bales SR, Chopra IJ (2011) Targeted treatment of differentiated and medullary thyroid cancer. J Thyroid Res 2011:102636.
3. Curtin K, Samowitz WS, Ulrich CM, et al. (2011) Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women. Nutr Cancer 63:357-366.
4. Dong X, Wu J, Liang P, et al. (2010) Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and gastric cancer: a meta-analysis. Arch Med Res 41:125-133.
5. Fard-Esfahani P, Fard-Esfahani A, Saidi P, et al. (2011) An increased risk of differentiated thyroid carcinoma in Iran with the 677C->T homozygous polymorphism in the MTHFR gene. Cancer Epidemiol 35:56-58.
6. Goyette P, Pai A, Milos R, et al. (1998) Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR). Mamm Genome 10:652-656; Erratum in Mamm Genome (1999) 10:204. (Pubitemid 28355328)
7. Hou P, Bojdani E, Xing M (2010) Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling patways. J Clin Endocrinol Metab 95:820-828.
8. Hustad S, Nedrebø BG, Ueland PM, et al. (2004) Phenotypic expression of the methylenetetrahydrofolate reductase 677C->T polymorphism and flavin cofactor availability in thyroid dysfunction. Am J Clin Nutr 80:1050-1057.
9. Izmirli M, Inandiklioglu N, Abat D, et al. (2011) MTHFR gene polymorphisms in bladder cancer in the Turkish population. Asian Pac J Cancer Prev 12:1833-1835.
10. James SJ, Melnyk S, Pogribna M, et al. (2002) Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr 132:2361-2366.
11. Kim HS, Kim do H, Kim JY, et al. (2010) Microarray analysis of papillary thyroid cancers in Korean. Korean J Intern Med 25:399-407.
12. Liu YX, Wang B, Wan MH, et al. (2011) Meta-analysis of the relationship between the metholenetetrahydrofolate reductase C677T genetic polymorphism, folate intake and esophageal cancer. Asian Pac J Cancer Prev 12:247-252.
13. Lu C, Mishra A, Zhu YJ, et al. (2011) Genomic profiling of genes contributing to metastasis in a mouse model of thyroid fol-licular carcinoma. Am J Cancer Res 1:1-13.
14. Lu C, Xie H, Wang F, et al. (2011) Diet folate, DNA methylation and genetic polymorphisms of MTHFR C677T in association with the prognosis of esophageal squamous cell carcinoma. BMC Cancer 11:91.
15. Luczak MW, Jagodzinski PP (2006) The role of DNA methyla-tion in cancer development. Folia Histochem Cytobiol 44: 143-154. (Pubitemid 44131981)
16. Melo SS, Persuhn DC, Meirelles MS, et al. (2006) Polymorphisms in the methylene-tetrahydrofolate gene: effect of folic acid on homocysteine levels. Mol Nutr Food Res 50:769-774. (Pubitemid 44342474)
17. Momparler RL, Bovenzi V (2000) DNA methylation and cancer. J Cell Physiol 183:145-154. (Pubitemid 30185933)
18. Moses W, Weng J, Sansano I, et al. (2010) Molecular testing for somatic mutations improves the accuracy of thyroid fine-needle aspiration biopsy. World J Surg 34:2589-2594.
19. Moura MM, Cavaco BM, Pinto AE, Leite V (2011) High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab 96:863-868.
20. Namba H, Nakashima M, Hayashi T, et al. (2003) Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 88:4393-4397. (Pubitemid 37153748)
21. Ozdemir O, Yildiz S, Ayan S, et al. (2010) Promoter hy-permethylation of tissue specific tumor supressor genes and point mutation in K-ras, c-myc proto-oncogenes in urinary (transitional cell) bladder carcinoma. Health 2:850-856.
22. Rouissi K, Stambouli N, Marrakchi R, et al. (2011) Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors. Bull Cancer 98:E1-E10.
23. Russo D, Damante G, Puxeddu E, et al. (2011) Epigenetics of thyroid cancer and novel therapeutic targets. J Mol Endocrinol 46:R73-R81.
24. Sato F, Meltzer SJ (2006) CpG island hypermethylation in progression of esophageal and gastric cancer. Cancer 106:483-493. (Pubitemid 43157610)
25. Schulz WA, Hoffmann MJ (2009) Epigenetic mechanisms in the biology of prostate cancer. Semin Cancer Biol 19:172-180.
26. Stephen JK, Chitale D, Narra V, et al. (2011) DNA methylation in thyroid tumorigenesis. Cancers (Basel) 3:1732-1743.
27. Supic G, Jovic N, Kozomara R, et al. (2011) Interaction between the MTHFR C677T polymorphism and alcohol-impact on oral cancer risk and multiple DNA methylation of tumor-related genes. J Dental Res 90:65-70.
28. Tsai CW, Hsu CF, Tsai MH, et al. (2011) Methylenetetrahy-drofolate reductase (MTHFR) genotype, smoking habit, metastasis and oral cancer in Taiwan. Anticancer Res 31:2395-2399.
29. van der Put NM, Gabreëls F, Stevens EM, et al. (1998) A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62:1044-1051. (Pubitemid 28199004)
30. Vineis P, Chuang SC, Vaissière T, et al.; Genair-EPIC Collaborators (2011) DNA methylation changes associated with cancer risk factors and blood levels of vitamin metabolites in a prospective study. Epigenetics 6:195-201.
31. Wang J, Sasco AJ, Fu C, et al. (2008) Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev 17:118-125. (Pubitemid 351196281)
32. Weier HU, Kwan J, Lu CM, et al. (2009) Kinase expression and chromosomal rearrangements in papillary thyroid cancer tissues: investigations at the molecular and microscopic levels. J Physiol Pharmacol 60 Suppl 4:47-55.
33. Weisberg I, Tran P, Christensen B, et al. (1998) A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64:169-172. (Pubitemid 28453294)
34. Zacho J, Yazdanyar S, Bojesen SE, et al. (2011) Hyperhomocys-teinemia, methylenetetrahydrofolate reductase c.677C> T polymorphism and risk of cancer: cross-sectional and prospective studies and meta-analyses of 75, 000 cases and 93, 000 controls. Int J Cancer 128:644-652.