Inhibition of cellular and systemic inflammation cues in human bronchial epithelial cells by melanocortin-related peptides: Mechanism of KPV action and a role for MC3R agonists

International Journal of Physiology, Pathophysiology and Pharmacology

Volumn 4, Issue 2, 2012, Pages 59-73

  Land, Stephen C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

melanocyte stimulating hormone derived tripeptide; melanocyte stimulating hormone ( MSH); Airway epithelium; Asthma; Chemokine signaling; Inflammation; KPV; MC3R; Melanocortin receptor

Indexed keywords

ALPHA INTERMEDIN; EOTAXIN; GAMMA INTERMEDIN; GELATINASE B; HORMONE RECEPTOR STIMULATING AGENT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; KARYOPHERIN ALPHA; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 3 RECEPTOR AGONIST; PEPTIDE KPV; TRANSCRIPTION FACTOR RELA; TRIPEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; ASSAY; BINDING SITE; BRONCHITIS; BRONCHUS MUCOSA; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; NUCLEAR IMPORT; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN STABILITY; RESPIRATORY EPITHELIUM; RESPIRATORY SYNCYTIAL PNEUMOVIRUS;

EID: 84863952469     PISSN: None     EISSN: 19448171     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Catania A, Gatti S, Colombo G, Lipton JM. Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev 2004; 56: 1-29.
2. Wong KY, Rajora N, Boccoli G, Catania A, Lipton JM. A potential mechanism of local antiinflammatory action of α-melanocyte-stimulating hormone within the brain: modulation of tumor necrosis factor-α production by human astrocytic cells. Neuroimmunomodulation 1997; 4: 37-41.
3. Delgado R, Carlin A, Airaghi L, Demitri MT, Meda L, Galimberti D, Baron P, Lipton JM, Catania A. Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia. J Leukoc Biol 1998; 63: 740-745.
4. Galimberti D, Baron P, Meda L, Prat E, Scarpini E, Delgado R, Catania A, Lipton JM, Scarlato G. α-MSH peptides inhibit production of nitric oxide and tumor necrosis factor-α by microglial cells activated with β-amyloid and interferon-γ. Biochem Biophys Res Commun 1999; 263: 251-256.
5. Barcellini W, Colombo G, La Maestra L, Clerici G, Garofalo L, Brini AT, Lipton JM, Catania A. α-Melanocyte-stimulating hormone peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes. J Leukoc Biol 2000; 68: 693-699.
6. Moustafa M, Szabo M, Ghanem GE, Morandini R, Kemp EH, MacNeil S, Haycock JW. Inhibition of tumor necrosis factor-α stimulated NFκB/ p65 in human keratinocytes by α-melanocyte stimulating hormone and adrenocorticotropic hormone peptides. J Invest Dermatol 2002; 119: 1244-1253.
7. Capsoni F, Ongari A, Colombo G, Turcatti F, Catania A. The synthetic melanocortin (CKPV)2 exerts broad anti-inflammatory effects in human neutrophils. Peptides 2007; 28: 2016-2022.
8. Brzoska T, Luger TA, Maaser C, Abels C, Böhm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo, and future perspectives for the treatment of immune-mediated inflammatory diseases. Endocr Rev 2008; 29: 581-602.
9. Dalmasso G, Charrier-Hisamuddin L, Thu Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology 2008; 134: 166-178.
10. Blalock JE. Complementarity of peptides specified by 'sense' and 'antisense' strands of DNA. TIBTECH 1991; 6: 140-144.
11. Siemion IZ, Cebrat M, Kluczyk A. The Problem of Amino Acid Complementarity and Antisense Peptides. Curr Prot Peptide Sci 2004; 5: 507-527.
12. Chelsky D, Ralph R and Jonak G. Sequence requirements for synthetic peptide-mediated translocation to the nucleus. Mol Cell Biol 1989; 9: 2487-2492.
13. Fontes MR, Teh T, Kobe B. Structural basis of recognition of monopartite and bipartite nuclear localization sequences by mammalian importin-α. J Mol Biol 2000; 297: 1183-1194.
14. Fagerlund R, Kinnunen L, Köhler M, Julkunen I, Melén K. NF-κB is transported into the nucleus by importin-α3 and importin-α4. J Biol Chem 2005; 280: 15942-15951.
15. Cozens AL, Yezzi MJ, Kunzelmann K, Ohrui T, Chin L, Eng K, Finkbeiner WE, Widdicombe JH, Gruenert DC. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am J Respir Cell Mol Biol 1994; 10: 38-47.
16. Hunter MJ, Treharne KJ, Winter AK, Cassidy DM, Land S, Mehta A. Expression of wild-type CFTR suppresses NF-κB-driven inflammatory signalling. PLoS One 2010; 5: e11598.
17. Suzuki M. SPKK, a new nucleic acid-binding unit of protein found in histone. EMBO J 1989; 8: 797-804.
18. Reeves R and Nissen MS. The A. T-DNA binding domain of mammalian high mobility group I chromosomal proteins. J Biol Chem 1990; 265: 8573-8582.
19. Land SC, Darakhshan F. Thymulin evokes IL-6-C/EBPbeta regenerative repair and TNF-alpha silencing during endotoxin exposure in fetal lung explants. Am J Physiol Lung Cell Mol Physiol 2004; 286: L473-487.
20. Land SC, Tee AR. Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem 2007; 282: 20534-20543.
21. Cooper A, Robinson SJ, Pickard C, Jackson CL, Friedmann PS, Healy E. α-melanocytestimulating hormone suppresses antigeninduced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status. J Immunol 2005; 175: 4806-4813.
22. Petsalaki E, Stark A, García-Urdiales E, Russell RB. Accurate prediction of peptide binding sites on protein surfaces. PLoS Comput Biol 2009; 5: e1000335.
23. Depping R, Steinhoff A, Schindler SG, Friedrich B, Fagerlund R, Metzen E, Hartmann E, Köhler M. Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway. Biochim Biophys Acta 2008; 1783: 394-404.
24. Melen K, Fagerlund R, FrankeJ, Kohler M, Kinnunen L and Julkunen I. Importin alpha nuclear localization signal binding sites for STAT1, STAT2, and influenza A virus nucleoprotein. J Biol Chem 2003; 278: 28193-28200.
25. Cannon JG, Tatro JB, Reichlin S, Dinarello CA. α-Melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1. J Immunol 1986; 137: 2232-2236.
26. Lee SN, Ryu JH, Joo JH, Choi YH, Lee HJ, Kim YJ, Kim KB, Yoon JH. α-Melanocyte-stimulating hormone Inhibits TNFα stimulated MUC5AC expression in human nasal epithelial cells. Am J Respir Cell Mol Biol 2010; epub ahead of print.
27. Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M, Spina D. A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther 2008; 21: 866-873.
28. Raap U, Brzoska T, Sohl S, Path G, Emmel J, Herz U, Braun A, Luger T, Renz H. α-Melanocyte-stimulating hormone inhibits allergic airway inflammation. J Immunol 2003; 171: 353-359.
29. Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Curr Opin Pharmacol 2009; 9: 375-383.