Thymulin evokes IL-6-C/EBPβ regenerative repair and TNF-α silencing during endotoxin exposure in fetal lung explants

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 286, Issue 3 30-3, 2004, Pages

  Land, Stephen C ^a   Darakhshan, Froogh ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Bronchopulmonary dysplasia; Cytoprotection; Fibroblast growth factor; Lung morphogenesis; Mitogen activated protein kinase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; FIBROBLAST GROWTH FACTOR; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; RNA; THYMULIN; TUMOR NECROSIS FACTOR ALPHA; ZINC ION;

ARTICLE; CHORIOAMNIONITIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; FETUS LUNG; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG DISEASE; LUNG DYSPLASIA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 1242351897     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00401.2002     Document Type: Article

References (52)

1. Adams DS, Nathans R, Pero SC, Sen A, and Wakshull E. Activation of a rel-A/CEBP-β-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line. J Cell Biochem 77: 221-233, 2000.
2. Akira S and Kishimoto T. NF-IL6 and NF-κB in cytokine gene regulation. Adv Immunol 65: 1-46, 1997.
3. + transport in rat fetal distal lung epithelial cells. J Physiol 532: 105-113, 2001.
4. Barker PM and Gatzy JT. Effect of gas composition on liquid secretion by explants of distal lung of fetal rat in submersion culture. Am J Physiol Lung Cell Mol Physiol 265: L512-L517, 1993.
5. Bellusci S, Grindley J, Emoto H, Itoh N, and Hogan BL. Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124: 4867-4878, 1997.
6. Bolender RP, Hyde DM, and Dehoff RT. Lung morphometry: a new generation of tools and experiments for organ, tissue, cell and molecular biology. Am J Physiol Lung Cell Mol Physiol 265: L521-L548, 1993.
7. Buck M, Poli V, Hunter T, and Chojkier M. C/EBPβ phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell 8: 807-816, 2001.
8. Buckley S and Warburton D. Dynamics of metalloproteinase-2 and -9, TGF-β, and uPA activities during normoxic vs. hyperoxic alveolarization. Am J Physiol Lung Cell Mol Physiol 283: L747-L754, 2002.
9. Cassel TN, Nordlund-Moller L, Andersson O, Gustafsson JA, and Nord M. C/EBPα and C/EBPδ activate the clara cell secretory protein gene through interaction with two adjacent C/EBP-binding sites. Am J Respir Cell Mol Biol 22: 469-480, 2000.
10. Chen RH, Chang MC, Su YH, Tsai YT, and Kuo ML. Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 274: 23013-23019, 1999.
11. WAF1/CIP1 via C/EBPβ. Nat Med 3: 1233-1241, 1997.
12. Colvin JS, Feldman B, Nadeau JH, Goldfarb M, and Ornitz DM. Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene. Dev Dyn 216: 72-88, 1999.
13. Colvin JS, White AC, Pratt SJ, and Ornitz DM. Lung hypoplasia and neonatal death in FGF-9-null mice identify this gene as an essential regulator of lung mesenchyme. Development 128: 2095-2106, 2001.
14. Croniger CM, Millward C, Yang J, Kawai Y, Arinze IJ, Liu S, Harada-Shiba M, Chakravarty K, Friedman JE, Poli V, and Hanson RW. Mice with a deletion in the gene for CCAAT/enhancer-binding protein β have an attenuated response to cAMP and impaired carbohydrate metabolism. J Biol Chem 276: 629-638, 2001.
15. Dardenne M, Pleau JM, Nabarra B, Lefrancier P, Derrien M, Choay J, and Bach JF. Contribution of zinc and other metals to the biological activity of the serum thymic factor. Proc Natl Acad Sci USA 79: 5370-5373, 1982.
16. Fisher JC, Kling DE, Kinane TB, and Schnitzer JJ. Oxidation-reduction (redox) controls fetal hypoplastic lung growth. J Surg Res 106: 287-291, 2002.
17. Flodby P, Barlow C, Kylefjord H, Ahrlund-Richter L, and Xanthopoulos KG. Increased hepatic cell proliferation, and lung abnormalities in mice deficient in CCAAT/enhancer binding protein α. J Biol Chem 271: 24753-24760, 1996.
18. 2+ in the alveolar epithelium: amelioration of endotoxin-induced cytokine release and partial amplification of a cytoprotective IL-10-sensitive pathway. Biochem Biophys Res Commun 274: 500-505, 2000.
19. Hilfer SR. Morphogenesis of the lung: control of embryonic and fetal branching. Annu Rev Physiol 58: 93-113, 1996.
20. Hu HM, Tian Q, Baer M, Spooner CJ, Williams SC, Johnson PF, and Schwartz RC. The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1. J Biol Chem 275: 16373-16381, 2000.
21. Iqbal AS, Shahidullah M, Islam MN, Akhter S, and Banu S. Serum zinc, and copper levels in the maternal blood and cord blood of neonates. Indian J Pediatr 68: 523-526, 2001.
22. Jaskoll T, Boyer PD, and Melnick M. Tumor necrosis factor-α and embryonic mouse lung morphogenesis. Dev Dyn 201: 137-150, 1994.
23. Kaartinen V, Voncken JW, Shuler C, Warburton D, Bu D, Heisterkamp N, and Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-β 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet 11: 415-421, 1995.
24. Kramer BW, Moss TJ, Willet KE, Newnham JP, Sly PD, Kallapur SG, Ikegami M, and Jobe AH. Dose and time response after intraamniotic endotoxin in preterm lambs. Am J Respir Crit Care Med 164: 982-988, 2001.
25. Kramer BW, Kramer S, Ikegami M, and Jobe AH. Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin. Am J Physiol Lung Cell Mol Physiol 283: L452-L459, 2002.
26. Krochmal-Mokrzan EM, Barker PM, and Gatzy JT. Effects of hormones on potential difference and liquid balance across explants from proximal and distal fetal rat lung. J Physiol 463: 647-665, 1993.
27. Matsumoto-Yoshitomi S, Seko C, Kuroshima K, Naruo K, Shino A, Kondo T, and Kurokawa T. Stimulation of thrombopoiesis in mice by fibroblast growth factor 9. Growth Factors 12: 179-190, 1995.
28. Matthys P, Mitera T, Heremans H, van Damme J, and Billiau A. Anti-γinterferon and anti-interleukin-6 antibodies affect staphylococcal enterotoxin B-induced weight loss, hypoglycemia and cytokine release in D-galactose-sensitized and unsensitized mice. Infect Immun 63: 1158-1164, 1995.
29. Miyauchi M, Koshikawa N, Kowamura K, Fukushima T, Mochizuki S, Awaya A, and Maruyama K. Augmentation with serum thymic factor of suppressive effects on retroviral tumor development in hosts immune to v-onc product. Leukemia 3: 213-215, 1997.
30. Mocchegiani E, Perissin L, Santarelli L, Tibaldi A, Zorzet S, Rapozzi V, Giacconi R, Bulian D, and Giraldi T. Melatonin administration in tumor-bearing mice (intact and pinealectomized) in relation to stress, zinc, thymulin and IL-2. Int J Immunopharmacol 21: 27-46, 1999.
31. Moss TJ, Newnham JP, Willett KE, Kramer BW, Jobe AH, and Ikegami M. Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry. Am J Respir Crit Care Med 165: 805-811, 2002.
32. Miyazaki Y, Araki K, Vesin C, Garcia I, Kapanci Y, Whitsett JA, Piguet PF, and Vassalli P. Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis. J Clin Invest 96: 250-259, 1995.
33. Neininger A, Kontoyiannis D, Kotlyarov A, Winzen R, Eckert R, Volk HD, Holtmann H, Kollias G, and Gaestel M. MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. J Biol Chem 277: 3065-3068, 2002.
34. Pantelidis P, Fanning GC, Wells AU, Welsh KI, and Du Bois RM. Analysis of tumor necrosis factor-α, lymphotoxin-α, tumor necrosis factor receptor II, and interleukin-6 polymorphisms in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 163: 1432-1436, 2001.
35. Piguet PF, Tacchini-Cottier F, and Vesin C. Administration of anti-TNF-α or anti-CD11a antibodies to normal adult mice decreases lung and bone collagen content: evidence for an effect on platelet consumption. Am J Respir Cell Mol Biol 12: 227-231, 1995.
36. 2 alters the bioelectric properties of fetal distal lung epithelium. Am J Physiol Lung Cell Mol Physiol 270: L1060-L1066, 1996.
37. Poli V. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J Biol Chem 273: 29279-29282, 1998.
38. Rousseau S, Morrice N, Peggie M, Campbell DG, Gaestel M, and Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J 21: 6505-6514, 2002.
39. Safieh-Garabedian B, Ahmed K, Khamashta MA, Taub NA, and Hughes GR. Thymulin modulated cytokine release by peripheral blood mononuclear cells: a comparison between healthy volunteers and patients with systemic lupus erythematosus. Int Arch Allergy Immunol 101: 126-131, 1993.
40. Savino W and Dardenne M. Neuroendocrine control of thymus physiology. Endocr Rev 21: 412-443, 2000.
41. Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, and Dinarello CA. Correlations and interactions in the production of interleukin-6 (IL-6). IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75: 40-47, 1990.
42. Schultz C, Rott C, Temming P, Schlenke P, Moller JC, and Bucsky P. Enhanced interleukin-6 and interleukin-8 synthesis in term and preterm infants. Pediatr Res 51: 317-322, 2002.
43. Screpanti I, Musiani P, Bellavia D, Cappelletti M, Aiello FB, Maroder M, Frati L, Modesti A, Gulino A, and Poli V. Inactivation of the IL-6 gene prevents development of multicentric Castleman's disease in C/EBP β-deficient mice. J Exp Med 184: 1561-1566, 1996.
44. Tanaka T, Kanda T, McManus BM, Kanai H, Akiyama H, Sekiguchi K, Yokoyama T, and Kurabayashi M. Overexpression of interleukin-6 aggravates viral myocarditis: impaired increase in tumor necrosis factor-α. J Mol Cell Cardiol 33: 1627-1635, 2001.
45. Vayrynen O, Glumoff V, and Hallman M. Regulation of surfactant proteins by LPS and proinflammatory cytokines in fetal and newborn lung. Am J Physiol Lung Cell Mol Physiol 282: L803-L810, 2002.
46. Vernooy JH, Dentener MA, van Suylen RJ, Buurman WA, and Wouters EF. Long-term intratracheal lipopolysaccharide exposure in mice results in chronic lung inflammation and persistent pathology. Am J Respir Cell Mol Biol 26: 152-159, 2002.
47. Wang J, Homer RJ, Chen Q, and Elias JA. Endogenous and exogenous IL6 inhibit aeroallergen-induced Th2 inflammation. J Immunol 165: 4051-4061, 2000.
48. Wang ND, Finegold MJ, Bradley A, Ou CN, Abdelsayed SV, Wilde MD, Taylor LR, Wilson DR, and Darlington GJ. Impaired energy homeostasis in C/EBPα knockout mice. Science 269: 1108-1112, 1995.
49. Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, and Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. Am J Respir Cell Mol Biol 22: 535-542, 2000.
50. Willet KE, Kramer BW, Kallapur SG, Ikegami M, Newnham JP, Moss TJ, Sly PD, and Jobe AH. Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung. Am J Physiol Lung Cell Mol Physiol 282: L411-L420, 2002.
51. Yara S, Kawakami K, Kudeken N, Tohyama M, Teruya K, Chinen T, Awaya A, and Saito A. FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice. Clin Exp Immunol 124: 77-85, 2001.
52. Young SL, Evans K, and Eu JP. Nitric oxide modulates branching morphogenesis in fetal rat lung explants. Am J Physiol Lung Cell Mol Physiol 282: L379-L385, 2002.