Relevance of lysine snorkeling in the outer transmembrane domain of small viral potassium ion channels

Biochemistry

Volumn 51, Issue 28, 2012, Pages 5571-5579

  Gebhardt, Manuela ^a   Henkes, Leonhard M ^c   Tayefeh, Sascha ^a   Hertel, Brigitte ^a   Greiner, Timo ^a   Van Etten, James L ^b   Baumeister, Dirk ^a   Cosentino, Cristian ^d   Moroni, Anna ^d   Kast, Stefan M ^c   Thiel, Gerhard ^a  

^a DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^c TU DORTMUND UNIVERSITY   (Germany)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BI-LAYER; CATIONIC AMINO ACIDS; CHARGED GROUPS; CYTOSOLIC; MOLECULAR DYNAMICS SIMULATIONS; N-TERMINAL TRUNCATION; NATURAL AMINO ACIDS; POLAR INTERFACE; POTASSIUM ION CHANNELS; PROTONATION STATE; SELECTIVITY FILTER; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; BIOLOGICAL MEMBRANES; MOLECULAR DYNAMICS; PROTONATION;

AMINO ACIDS;

LYSINE; MEMBRANE PROTEIN; MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCVATCV 1; POTASSIUM CHANNEL KCVMT325; PROTEIN K29; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CYTOSOL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ELECTROPHYSIOLOGICAL PHENOMENA; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; LYSINE; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; VIRAL PROTEINS;

EID: 84863928449     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi3006016     Document Type: Article

References (23)

1. Landolt-Marticorena, C., Williams, K. A., Deber, C. M., and Reithmeier, R. A. F. (1993) Non-random distribution of amino acids in the transmembrane segments of human type I single span membrane proteins J. Mol. Biol. 229, 602-608
2. Von Heijne, G. (1994) Membrane proteins: From sequence to structure Annu. Rev. Biophys. Biomol. Struct. 23, 167-192
3. Arkin, I. T. and Brunger, A. T. (1998) Statistical analysis of predicted transmembrane α-helices Biochim. Biophys. Acta 1429, 113-128
4. Ulmschneider, M. B. and Sansom, M. S. (2001) Amino acid distributions in integral membrane protein structures Biochim. Biophys. Acta 1512, 1-14
5. Kim, C., Schmidt, T., Cho, E.-G., Ye, F., Ulmer, T. S., and Ginsberg, M. H. (2012) Basic amino acid side chains regulate transmembrane integrin signaling Nature 481, 209-213
6. Segrest, J. P., De Loof, H., Dohlman, J. G., Brouillette, C. G., and Anantharamaiah, G. M. (1990) Amphipathic helix motif: Classes and properties Proteins 8, 103-117
7. Strandberg, E. and Killian, J. A. (2003) Snorkeling of lysine side chains in transmembrane helices: How easy can it get? FEBS Lett. 544, 69-73
8. Kandasamy, S. K. and Larson, R. (2006) Molecular dynamics simulations of model trans-membrane peptides in lipid bilayers: A systematic investigation of hydrophobic mismatch Biophys. J. 90, 2326-2343
9. Plugge, B., Gazzarrini, S., Nelson, M., Cerana, R., Van Etten, J. L., Derst, C., DiFrancesco, D., Moroni, A., and Thiel, G. (2000) A potassium channel protein encoded by Chlorella virus PBCV-1 Science 287, 1641-1644
10. Tayefeh, S., Kloss, T., Thiel, G., Hertel, B., Moroni, A., and Kast, S. M. (2007) Molecular dynamics simulation study of the cytosolic mouth in Kcv-type potassium channels Biochemistry 46, 4826-4839
11. Tayefeh, S., Kloss, T., Kreim, M., Gebhardt, M., Baumeister, D., Hertel, B., Richter, C., Schwalbe, H., Moroni, A., Thiel, G., and Kast, S. M. (2009) Model development for the viral potassium channel Biophys. J. 96, 485-498
12. Hamacher, K., Greiner, T., Ogata, H., Van Etten, J. L., Gebhardt, M., Villarreal, L. P., Cosentino, C., Moroni, A., and Thiel, G. (2012) Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis PLoS One 7, e38826
13. Kang, M., Moroni, A., Gazzarrini, S., DiFrancesco, D., Thiel, G., Severino, M., and Van Etten, J. L. (2004) Small potassium ion channel protein encoded by Chlorella viruses Proc. Natl. Acad. Sci. U.S.A. 101, 5318-5324
14. + channels is a signal for mitochondria targeting Proc. Natl. Acad. Sci. U.S.A. 105, 12313-12318
15. Hertel, B., Tayefeh, S., Kloss, T., Hewing, J., Gebhardt, M., Baumeister, D., Moroni, A., Thiel, G., and Kast, S. M. (2009) Salt bridges in the miniature viral channel Kcv are important for function Eur. Biophys. J. 39, 1057-1068
16. Chou, P. Y. and Fasman, G. D. (1978) Prediction of the secondary structure of proteins from their amino acid sequence Adv. Enzymol. 47, 45-148
17. ONeil, K. T. and DeGrado, W. F. (1990) A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids Science 250, 646-651
18. Cordes, F. S., Bright, J. N., and Sansom, M. S. P. (2002) Proline-induced distortions of transmembrane helices J. Mol. Biol. 323, 951-960
19. Gazzarrini, S., Kang, M., Epimashko, S., Van Etten, J. L., Dainty, J., Thiel, G., and Moroni, A. (2006) Chlorella virus MT325 encodes water and potassium channels that interact synergistically Proc. Natl. Acad. Sci. U.S.A. 103, 5355-5360
20. Gazzarrini, S., Kang, M., Abenavoli, A., Romani, G., Olivari, C., Gaslini, D., Ferrara, G., Van Etten, J. L., Kreim, M., Kast, S. M., Thiel, G., and Moroni, A. (2009) Chlorella virus ATCV-1 encodes a functional potassium channel of 82 amino acids Biochem. J. 420, 295-303
21. + channel function J. Biol. Chem. 286, 11299-11306
22. Wimley, W. C. and White, W. S. (1996) Experimentally determined hydrophobicity scale for proteins at membrane interfaces Nat. Struct. Biol. 3, 842-848
23. Jayasinghe, S., Hristova, K., and White, S. H. (2001) Energetics, stability, and prediction of transmembrane helices J. Mol. Biol. 312, 927-934